PLK1 Monoclonal Antibody (36-298) | Invitrogen 37-7100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PLK1 Monoclonal Antibody (36-298)

catalog :

37-7100

quantity :

100 µg

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

36-298

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 1	Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
immunohistochemistry; human	Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, et al. FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas. BMC Res Notes. 2015;8:676 pubmed publisher
western blot; human; 1:200; fig 4	Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, et al. Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. Int J Cancer. 2011;129:2134-46 pubmed publisher
	El Khobar K, Tay E, Diefenbach E, Gloss B, George J, Douglas M. Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer. Life Sci Alliance. 2023;6: pubmed publisher
	Xu L, Ali M, Duan W, Yuan X, Garba F, Mullen M, et al. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation. Cell Rep. 2021;36:109343 pubmed publisher
	Han H, Davidson L, Fan Y, Goldsby J, Yoon G, Jin U, et al. Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells. EMBO J. 2020;39:e104319 pubmed publisher
	Liu C, Shi Y, Li J, Liu X, Xiahou Z, Tan Z, et al. O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes. J Biol Chem. 2020;295:7341-7349 pubmed publisher
	Inoko A, Yano T, Miyamoto T, Matsuura S, Kiyono T, Goshima N, et al. Albatross/FBF1 contributes to both centriole duplication and centrosome separation. Genes Cells. 2018;23:1023-1042 pubmed publisher
	Adam K, Cartel M, Lambert M, David L, Yuan L, Besson A, et al. A PIM-CHK1 signaling pathway regulates PLK1 phosphorylation and function during mitosis. J Cell Sci. 2018;131: pubmed publisher
	Zhang N, Pati D. Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. J Cancer Sci Ther. 2018;10: pubmed publisher
	Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa E, et al. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic Î²Â Cell Proliferation. Cell Metab. 2017;25:868-882.e5 pubmed publisher
	Duan H, Wang C, Wang M, Gao X, Yan M, Akram S, et al. Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation. J Biol Chem. 2016;291:21123-21136 pubmed
	Dai G, Qian Y, Chen J, Meng F, Pan F, Shen W, et al. Calmodulin activation of polo-like kinase 1 is required during mitotic entry. Biochem Cell Biol. 2013;91:287-94 pubmed publisher
	Chen F, Ohashi N, Li W, Eckman C, Nguyen J. Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure. Hepatology. 2009;50:1914-23 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PLK1 Monoclonal Antibody (36-298)

Catalog # :

37-7100

Quantity :

100 µg

Price :

US 450

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Clone :

36-298

Isotype :

IgG1

Storage :

-20°C

Description :

PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.

Immunogen :

Full-length human Plk1

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

cell cycle regulated protein kinase; Plk; PLK 1; Plk1; PLK-1; plk1.S; plx1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; polo like kinase 1 S homeolog; polo-like kinase; polo-like kinase 1; polo-like kinase homolog; polo-like protein kinase; serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; Unknown (protein for MGC:133927); XELAEV_18047692mg

more info or order :

Invitrogen product webpage