FBXO5 Monoclonal Antibody (3D2D6) | Invitrogen 37-6600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FBXO5 Monoclonal Antibody (3D2D6)

catalog :

37-6600

quantity :

100 µg

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D2D6

reactivity :

human

application :

western blot, ELISA

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; fig 3	Feringa F, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, et al. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun. 2016;7:12618 pubmed publisher
western blot; human; 1:100; fig s6	Ercilla A, Llopis A, Feu S, Aranda S, Ernfors P, Freire R, et al. New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. Nucleic Acids Res. 2016;44:4745-62 pubmed publisher
western blot; human	Voets E, Wolthuis R. MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C. Biol Open. 2015;4:484-95 pubmed publisher
western blot; human; 1:100	Yu Y, Munger K. Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis. Virology. 2013;446:251-9 pubmed publisher
western blot; human; 1:500; fig 1	Chen M, Gutierrez G, Ronai Z. The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. PLoS ONE. 2012;7:e35520 pubmed publisher
western blot; human; 1:100; fig 1	Moshe Y, Bar On O, Ganoth D, Hershko A. Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases. J Biol Chem. 2011;286:16647-57 pubmed publisher
western blot; human; fig 1	Lee J, Kim J, Margolis R, Fotedar R. Substrate degradation by the anaphase promoting complex occurs during mitotic slippage. Cell Cycle. 2010;9:1792-801 pubmed
western blot; human; fig 1	Lee J, Kim J, Barbier V, Fotedar A, Fotedar R. DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest. Mol Biol Cell. 2009;20:1891-902 pubmed publisher
	Segeren H, van Rijnberk L, Moreno E, Riemers F, van Liere E, Yuan R, et al. Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage. Cell Rep. 2020;33:108449 pubmed publisher
	Liu C, Konagaya Y, Chung M, Daigh L, Fan Y, Yang H, et al. Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity. Nat Commun. 2020;11:5305 pubmed publisher
	Subramanian G, Greaney J, Wei Z, Becherel O, Lavin M, Homer H. Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis. J Cell Biol. 2020;219: pubmed publisher
	Elbasani E, Gramolelli S, Gunther T, Gabaev I, Grundhoff A, Ojala P. Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity. J Virol. 2020;94: pubmed publisher
	Cappell S, Mark K, Garbett D, Pack L, Rape M, Meyer T. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. Nature. 2018;558:313-317 pubmed publisher
	Schoonen P, Talens F, Stok C, Gogola E, Heijink A, Bouwman P, et al. Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Nat Commun. 2017;8:15981 pubmed publisher
	Boekhout M, Yuan R, Wondergem A, Segeren H, van Liere E, Awol N, et al. Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression. EMBO Rep. 2016;17:414-27 pubmed publisher
	Kong D, Farmer V, Shukla A, James J, Gruskin R, Kiriyama S, et al. Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles. J Cell Biol. 2014;206:855-65 pubmed publisher
	Shimizu N, Nakajima N, Tsunematsu T, Ogawa I, Kawai H, Hirayama R, et al. Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells. J Biol Chem. 2013;288:17238-52 pubmed publisher
	Bar On O, Shapira M, Skorecki K, Hershko A, Hershko D. Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells. Cell Cycle. 2010;9:1986-9 pubmed

product information

Product Type :

Antibody

Product Name :

FBXO5 Monoclonal Antibody (3D2D6)

Catalog # :

37-6600

Quantity :

100 µg

Price :

US 430

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

3D2D6

Isotype :

IgG2a, kappa

Storage :

-20°C

Description :

F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.

Immunogen :

Synthetic peptide derived from the C-terminal region of human Emi1 (early mitotic inhibitor 1, Fbx5) protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Aliases :

2510044I10Rik; C85305; Early mitotic inhibitor 1; Emi1; f-box only protein 31; F-box only protein 5; F-box protein 5; F-box protein Fbx5; FBX5; Fbxo31; FBXO5

more info or order :

Invitrogen product webpage