DDB1 Monoclonal Antibody (2B12D1) | Invitrogen 37-6200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DDB1 Monoclonal Antibody (2B12D1)

catalog :

37-6200

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B12D1

reactivity :

human, mouse

application :

western blot, ELISA, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 3b	Hou L, Zhao J, Gao S, Ji T, Song T, Li Y, et al. Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase. Sci Adv. 2019;5:eaau7130 pubmed publisher
western blot; human; loading ...; fig 5a	Gao S, Geng C, Song T, Lin X, Liu J, Cai Z, et al. Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase. J Biol Chem. 2017;292:3683-3691 pubmed publisher
western blot; human; fig 4	Hrecka K, Hao C, Shun M, Kaur S, Swanson S, Florens L, et al. HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins. Proc Natl Acad Sci U S A. 2016;113:E3921-30 pubmed publisher
western blot; human; fig 2	Liu J, Ye J, Zou X, Xu Z, Feng Y, Zou X, et al. CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis. Nat Commun. 2014;5:3924 pubmed publisher
western blot; human; fig 1a	Srivastava S, Swanson S, Manel N, Florens L, Washburn M, Skowronski J. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog. 2008;4:e1000059 pubmed publisher
	Kumar N, Theil A, Roginskaya V, Ali Y, Calderon M, Watkins S, et al. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022;13:974 pubmed publisher
	Yan J, Shun M, Zhang Y, Hao C, Skowronski J. HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells. Proc Natl Acad Sci U S A. 2019;116:9568-9577 pubmed publisher
	Yan J, Shun M, Hao C, Zhang Y, Qian J, Hrecka K, et al. HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection. MBio. 2018;9: pubmed publisher
	Song T, Liang S, Liu J, Zhang T, Yin Y, Geng C, et al. CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory. PLoS Genet. 2018;14:e1007165 pubmed publisher
	Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan K, et al. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017;284:3619-3636 pubmed publisher
	Hussain S, Feldman A, Das C, Ziesmer S, Ansell S, Galardy P. Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor. Mol Cell Biol. 2013;33:1188-97 pubmed publisher
	Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson S, Florens L, et al. Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle. Proc Natl Acad Sci U S A. 2007;104:11778-83 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DDB1 Monoclonal Antibody (2B12D1)

Catalog # :

37-6200

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 2 ug/mL

Species :

Human, Mouse

Clone :

2B12D1

Isotype :

IgG1, kappa

Storage :

-20 C

Description :

The DNA damage-binding protein from HeLa cells is associated with polypeptides of relative mass 124,000 (DDB1) and 41,000 (DDB2) as determined by SDS-polyacrylamide gels. To test whether the DNA-repair defect in the subset of XPE patients that lack DNA damage-binding activity is caused by a defect in DDB, Keeney et al. (1994) injected purified human DDB protein into XPE cells.

Immunogen :

Recombinant human DDB1 protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 2 ug/mL

Aliases :

127kDa; AA408517; damage specific DNA binding protein 1; damaged-DNA recognition protein 1; damage-specific DNA binding protein 1, 127kDa; damage-specific DNA-binding protein 1; damage-specific DNA-binding protein, DNA repair; DDB p127 subunit; DDB1; DDBa; DNA damage-binding protein 1; DNA damage-binding protein a; DNA repair protein; HBV X-associated protein 1; p127-Ddb1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; XAP1; XAP-1; xeroderma pigmento; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE-BF; XPE-binding factor

more info or order :

Invitrogen product webpage