Nectin 1 Monoclonal Antibody (CK8) | Invitrogen 37-5900 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Nectin 1 Monoclonal Antibody (CK8)

catalog :

37-5900

quantity :

100 µg

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CK8

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse western blot; mouse	Arii J, Hirohata Y, Kato A, Kawaguchi Y. Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry. J Virol. 2015;89:1879-88 pubmed publisher
flow cytometry; human; 1:100; fig 6 immunocytochemistry; human; 1:50; fig 5	Shah A, Farooq A, Tiwari V, Kim M, Shukla D. HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection. Mol Vis. 2010;16:2476-86 pubmed
western blot; human; fig 1	Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, et al. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008;183:19-28 pubmed publisher
	Wu Y, Chen X, Wang L, Zhou X, Liu Y, Ji D, et al. Histone Deacetylase Inhibitor Panobinostat Benefits the Therapeutic Efficacy of Oncolytic Herpes Simplex Virus Combined with PD-1/PD-L1 Blocking in Glioma and Squamous Cell Carcinoma Models. Viruses. 2022;14: pubmed publisher
	Xu S, Xiao Q, Cosmanescu F, Sergeeva A, Yoo J, Lin Y, et al. Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits. Neuron. 2018;100:1369-1384.e6 pubmed publisher
	Ring E, Li R, Moore B, Nan L, Kelly V, Han X, et al. Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002. Mol Ther Oncolytics. 2017;7:27-36 pubmed publisher
	O Donnell C, Shukla D. A novel function of heparan sulfate in the regulation of cell-cell fusion. J Biol Chem. 2009;284:29654-65 pubmed publisher
	Shukla S, Singh Y, Shukla D. Role of nectin-1, HVEM, and PILR-alpha in HSV-2 entry into human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009;50:2878-87 pubmed publisher
	Akhtar J, Tiwari V, Oh M, Kovacs M, Jani A, Kovacs S, et al. HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium. Invest Ophthalmol Vis Sci. 2008;49:4026-35 pubmed publisher
	Sun J, Kintner J, Schoborg R. The host adherens junction molecule nectin-1 is downregulated in Chlamydia trachomatis-infected genital epithelial cells. Microbiology. 2008;154:1290-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Nectin 1 Monoclonal Antibody (CK8)

Catalog # :

37-5900

Quantity :

100 µg

Price :

US 430

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 0.1-1 µg/mL

Species :

Human, Mouse, Rat

Clone :

CK8

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region. This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome as well as non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

Immunogen :

Recombinant human Nectin-1 protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 0.1-1 µg/mL

Aliases :

AI835281; AW549174; CD111; CLPED1; ectodermal dysplasia 4 (Margarita Island type); ED4; herpes simplex virus type 1 sensitivity; herpes virus entry mediator C; Herpesvirus entry mediator C; herpesvirus Ig-like receptor; HIgR; HV1S; Hvec; nectin 1; nectin cell adhesion molecule 1; nectin); Nectin1; nectin-1; nectin-1 alpha; nectin-1 delta; OFC7; poliovirus receptor-like 1; poliovirus receptor-related 1; poliovirus receptor-related 1 (herpesvirus entry mediator C; poliovirus receptor-related 1 (herpesvirus entry mediator C); poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin); poliovirus receptor-related protein 1; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12

more info or order :

Invitrogen product webpage