ZO-2 Monoclonal Antibody (3E8D9) | Invitrogen 37-4700 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-2 Monoclonal Antibody (3E8D9)

catalog :

37-4700

quantity :

100 µg

price :

US 459.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3E8D9

reactivity :

human, dogs

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000	Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, et al. p38? mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes. Arch Dermatol Res. 2014;306:131-41 pubmed publisher
immunocytochemistry; human; 1:250; fig 7 western blot; human; 1:1000; fig 7	Cheung T, Ganatra M, Peters E, Truskey G. Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. Am J Physiol Heart Circ Physiol. 2012;303:H1374-83 pubmed publisher
flow cytometry; human; fig 4	Birnie R, Bryce S, Roome C, Dussupt V, Droop A, Lang S, et al. Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. Genome Biol. 2008;9:R83 pubmed publisher
immunoprecipitation; dogs	Huerta M, Munoz R, Tapia R, Soto Reyes E, Ramírez L, Recillas Targa F, et al. Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription factor c-Myc. Mol Biol Cell. 2007;18:4826-36 pubmed
	Haas A, Zihni C, Krug S, Maraspini R, Otani T, Furuse M, et al. ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions. Cells. 2022;11: pubmed publisher
	Skamrahl M, Pang H, Ferle M, Gottwald J, Rübeling A, Maraspini R, et al. Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration. Adv Sci (Weinh). 2021;8:e2100478 pubmed publisher
	Lin L, Kost E, Lin C, Valente P, Wang C, Kolonin M, et al. PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer. Cell Rep. 2020;33:108253 pubmed publisher
	Liu Y, Zhang Y, Li T, Han J, Wang Y. The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock. Nat Commun. 2020;11:589 pubmed publisher
	Cuellar P, Hernández Nava E, García Rivera G, Chavez Munguia B, Schnoor M, Betanzos A, et al. Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium. Front Cell Infect Microbiol. 2017;7:372 pubmed publisher
	Spadaro D, Tapia R, Jond L, Sudol M, Fanning A, Citi S. ZO proteins redundantly regulate the transcription factor DbpA/ZONAB. J Biol Chem. 2014;289:22500-11 pubmed publisher
	Kundumani Sridharan V, Dyukova E, Hansen D, Rao G. 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J Biol Chem. 2013;288:15830-42 pubmed publisher
	Yue S, Cárdenas Mora J, Chaboub L, LELIEVRE S, Cheng J. Label-free analysis of breast tissue polarity by Raman imaging of lipid phase. Biophys J. 2012;102:1215-23 pubmed publisher
	Flores C, Ene S, Pereda A. An immunochemical marker for goldfish Mauthner cells. J Neurosci Methods. 2008;175:64-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZO-2 Monoclonal Antibody (3E8D9)

Catalog # :

37-4700

Quantity :

100 µg

Price :

US 459.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Canine, Human

Clone :

3E8D9

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Immunogen :

Synthetic peptide derived from an internal amino acids of the human ZO-2 protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

C9DUPq21.11; DFNA51; DUP9q21.11; Friedreich ataxia region gene X104 (tight junction protein ZO-2); PFIC4; tight junction protein; tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO-2; Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2); Tjp2; X104; ZO2; ZO-2; zona occludens 2; zona occludens protein 2; Zonula occludens protein 2

more info or order :

Invitrogen product webpage