Connexin 47 Monoclonal Antibody (4A11A2) | Invitrogen 37-4500 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Connexin 47 Monoclonal Antibody (4A11A2)

catalog :

37-4500

quantity :

100 µg

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A11A2

reactivity :

mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:500; fig 2	Markoullis K, Sargiannidou I, Gardner C, Hadjisavvas A, Reynolds R, Kleopa K. Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis. Glia. 2012;60:1053-66 pubmed publisher
immunohistochemistry - frozen section; mouse; 2 ug/ml	Lynn B, Tress O, May D, Willecke K, Nagy J. Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges. Eur J Neurosci. 2011;34:1783-93 pubmed publisher
	Bouchat J, Couturier B, Marneffe C, Gankam Kengne F, Balau B, De Swert K, et al. Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood-brain barrier disruption in a murine model of osmotic demyelination syndrome. Glia. 2017;: pubmed publisher
	Schirmer L, Srivastava R, Kalluri S, Böttinger S, Herwerth M, Carassiti D, et al. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014;75:810-28 pubmed publisher
	Tress O, Maglione M, Zlomuzica A, May D, Dicke N, Degen J, et al. Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS Genet. 2011;7:e1002146 pubmed publisher
	Li X, Penes M, Odermatt B, Willecke K, Nagy J. Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions. Eur J Neurosci. 2008;28:1503-17 pubmed publisher
	Kamasawa N, Sik A, Morita M, Yasumura T, Davidson K, Nagy J, et al. Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning. Neuroscience. 2005;136:65-86 pubmed
	Penes M, Li X, Nagy J. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Eur J Neurosci. 2005;22:404-18 pubmed

product information

Product Type :

Antibody

Product Name :

Connexin 47 Monoclonal Antibody (4A11A2)

Catalog # :

37-4500

Quantity :

100 µg

Price :

US 430

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Mouse

Applications :

Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Clone :

4A11A2

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Immunogen :

Synthetic peptide derived from the C-terminal region of the mouse Connexin 47 protein

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

B230382L12Rik; connexin 47 type A; connexin 47 type C; connexin 47 type D; connexin-46.6; Connexin-47; CX46.6; Cx47; CXG2; gap junction alpha-12 protein; Gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein gamma 2; gap junction protein, alpha 12; gap junction protein, chi 2; gap junction protein, gamma 2; gap junction protein, gamma 2, 47kDa; GJA12; Gjc2; HLD2; LMPH1C; PMLDAR; SPG44

more info or order :

Invitrogen product webpage