EphA2 Monoclonal Antibody (1C11A12) | Invitrogen 37-4400 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EphA2 Monoclonal Antibody (1C11A12)

catalog :

37-4400

quantity :

100 µg

price :

US 500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C11A12

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:100; fig 3 immunocytochemistry; human; 1:100; fig s1	Lee H, Noh H, Mun J, Gu C, Sever S, Park S. Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis. Nat Commun. 2016;7:12799 pubmed publisher
immunohistochemistry; human; fig 3 western blot; human; fig 1	Lee J, Han H, Shahzad M, Kim S, Mangala L, Nick A, et al. EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma. J Natl Cancer Inst. 2009;101:1193-205 pubmed publisher
western blot; human; 1:10,000; fig 3	Damschroder M, Widjaja L, Gill P, Krasnoperov V, Jiang W, Dall Acqua W, et al. Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties. Mol Immunol. 2007;44:3049-60 pubmed
	Baggio C, Udompholkul P, Gambini L, Pellecchia M. Targefrin: A Potent Agent Targeting the Ligand Binding Domain of EphA2. J Med Chem. 2022;65:15443-15456 pubmed publisher
	Prakash P, Kruse A, Vogel C, Schagdarsurengin U, Wagenlehner F. Targeting Host Tyrosine Kinase Receptor EPHA2 Signaling Affects Uropathogen Infection in Human Bladder Epithelial Cells. Pathogens. 2022;11: pubmed publisher
	Kaminskyy V, Haag P, Novak M, Vegvari A, Arapi V, Lewensohn R, et al. EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells. Cancers (Basel). 2021;13: pubmed publisher
	Liu B, Sun W, Gao W, Li L, Cao Z, Yang X, et al. microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis. BMC Cancer. 2020;20:1019 pubmed publisher
	Salem A, Wang S, Billet S, Chen J, Udompholkul P, Gambini L, et al. Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate. J Med Chem. 2018;61:2052-2061 pubmed publisher
	Pewkliang Y, Rungin S, Lerdpanyangam K, Duangmanee A, Kanjanasirirat P, Suthivanich P, et al. A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax. Malar J. 2018;17:50 pubmed publisher
	Efazat G, Novak M, Kaminskyy V, De Petris L, Kanter L, Juntti T, et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget. 2016;7:60332-60347 pubmed publisher
	Prigozhina N, Heisel A, Wei K, Noberini R, Hunter E, Calzolari D, et al. Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Biol Cell. 2011;103:467-81 pubmed publisher
	Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M, et al. A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer Res. 2008;68:9367-74 pubmed publisher

product information

Product Type :

Antibody

Product Name :

EphA2 Monoclonal Antibody (1C11A12)

Catalog # :

37-4400

Quantity :

100 µg

Price :

US 500.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL

Species :

Human, Mouse, Rat

Clone :

1C11A12

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Immunogen :

Synthetic peptide derived from the C-terminal region of the human EphA2 Receptor protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL

Aliases :

ARCC2; AW545284; CTPA; CTPP1; CTRCT6; Eck; EPH receptor A2; Epha2; ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; I79_019726; Myk2; Sek2; Sek-2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2

more info or order :

Invitrogen product webpage