BTRC Monoclonal Antibody (1B1D2) | Invitrogen 37-3400 product information

product summary

company name :

Invitrogen

other brands :

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product type :

antibody

product name :

BTRC Monoclonal Antibody (1B1D2)

catalog :

37-3400

quantity :

100 µg

price :

US 430

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B1D2

reactivity :

human, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1l	Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher
western blot; human; fig 4b	Kim T, Siesser P, Rossman K, Goldfarb D, Mackinnon K, Yan F, et al. Substrate trapping proteomics reveals targets of the Î²TrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol. 2015;35:167-81 pubmed publisher
western blot; human	Wang D, Zhang P, Gao K, Tang Y, Jin X, Zhang Y, et al. PLK1 and Î²-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS ONE. 2014;9:e110296 pubmed publisher
western blot; human	Ram R, Mendiratta S, Bodemann B, Torres M, Eskiocak U, White M. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol Cell Biol. 2014;34:2350-8 pubmed publisher
western blot; human; fig 1	Siesser P, Motolese M, Walker M, Goldfarb D, Gewain K, Yan F, et al. FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. Sci Signal. 2012;5:ra64 pubmed publisher
western blot; human; fig 2	Su J, Cheng X, Yamaguchi H, Chang Y, Hou C, Lee D, et al. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011;71:6878-87 pubmed publisher
western blot; human	Tian Y, Kolb R, Hong J, Carroll J, Li D, You J, et al. TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007;27:6383-95 pubmed
	Ballout F, Lu H, Chen L, Sriramajayam K, Que J, Meng Z, et al. APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas. J Exp Clin Cancer Res. 2022;41:264 pubmed publisher
	Long B, Yang X, Xu X, Li X, Xu X, Zhang X, et al. Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR. Cell Death Dis. 2020;11:995 pubmed publisher
	Vind A, Snieckute G, Blasius M, Tiedje C, Krogh N, Bekker Jensen D, et al. ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains. Mol Cell. 2020;78:700-713.e7 pubmed publisher
	Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L, et al. Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer. Nucleic Acids Res. 2018;46:5809-5821 pubmed publisher
	Kang D, Lee D, Lee S, Lee S, Jun Y, Kim Y, et al. Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. Nat Commun. 2017;8:40 pubmed publisher
	Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed publisher
	Tseng R, Chang J, Mao J, Tsai C, Wu P, Lin C, et al. Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/Î²-TrCP/Î²-catenin pathways in lung cancer. Oncotarget. 2015;6:44207-21 pubmed publisher
	Hsu K, Kao H. ?-Transducin repeat-containing protein 1 (?-TrCP1)-mediated silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) protein degradation promotes tumor necrosis factor ? (TNF?)-induced inflammatory gene expression. J Biol Chem. 2013;288:25375-86 pubmed publisher
	Gao D, Inuzuka H, Tan M, Fukushima H, Locasale J, Liu P, et al. mTOR drives its own activation via SCF(?TrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011;44:290-303 pubmed publisher
	Kato T, Mizuno S, Nakamura T. Preservations of nephrin and synaptopodin by recombinant hepatocyte growth factor in podocytes for the attenuations of foot process injury and albuminuria in nephritic mice. Nephrology (Carlton). 2011;16:310-8 pubmed publisher
	Rada P, Rojo A, Chowdhry S, McMahon M, Hayes J, Cuadrado A. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol. 2011;31:1121-33 pubmed publisher
	Thomas Y, Coux O, Baldin V. βTrCP-dependent degradation of CDC25B phosphatase at the metaphase-anaphase transition is a pre-requisite for correct mitotic exit. Cell Cycle. 2010;9:4338-50 pubmed
	Lin R, Hsieh Y, Lin P, Hsu H, Chen C, Tang Y, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest. 2010;120:521-32 pubmed publisher
	Westbrook T, Hu G, Ang X, Mulligan P, Pavlova N, Liang A, et al. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008;452:370-4 pubmed publisher
	Mailand N, Bekker Jensen S, Bartek J, Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell. 2006;23:307-18 pubmed

product information

Product Type :

Antibody

Product Name :

BTRC Monoclonal Antibody (1B1D2)

Catalog # :

37-3400

Quantity :

100 µg

Price :

US 430

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL

Species :

Human, Rat

Clone :

1B1D2

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

Immunogen :

Recombinant human beta-TrCP fusion protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL

Aliases :

beta-transducin repeat containing E3 ubiquitin protein ligase; beta-transducin repeat containing protein; Beta-transducin repeat-containing protein; betaTrCP; Beta-TrCP; Beta-TrCP protein E3RS-IkappaB; Beta-Trcp1; Btrc; BTRCP; b-TrCP; bTrCP1; E3RSIkappaB; E3RS-IkappaB; epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; Fbw1; FBW1A; FBXW1; FBXW1A; FWD1; HOS; Kiaa4123; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A; mE3RS-IkappaB; pIkappaBalpha-E3 receptor subunit; pIkappaB-E3 receptor subunit; SCF b-TRCP; Slimb; Ubiquitin ligase FWD1

more info or order :

Invitrogen product webpage