RPL11 Monoclonal Antibody (3A4A7) | Invitrogen 37-3000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RPL11 Monoclonal Antibody (3A4A7)

catalog :

37-3000

quantity :

100 µg

price :

US 500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A4A7

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 8a	Wang H, Chen T, Weng C, Yang C, Tang M. Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells. Oncotarget. 2016;7:80450-80464 pubmed publisher
western blot; human	Scala F, Brighenti E, Govoni M, Imbrogno E, Fornari F, TrerÃ© D, et al. Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene. 2016;35:977-89 pubmed publisher
western blot; human	Kardos G, Dai M, Robertson G. Growth inhibitory effects of large subunit ribosomal proteins in melanoma. Pigment Cell Melanoma Res. 2014;27:801-12 pubmed publisher
	Smith L, Parmenter T, Kleinschmidt M, Kusnadi E, Kang J, Martin C, et al. Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma. Nat Commun. 2022;13:1100 pubmed publisher
	Kanellis D, Espinoza J, Zisi A, Sakkas E, Bartkova J, Katsori A, et al. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output. Sci Adv. 2021;7: pubmed publisher
	Dong Z, Jiang H, Liang S, Wang Y, Jiang W, Zhu C. Ribosomal Protein L15 is involved in Colon Carcinogenesis. Int J Med Sci. 2019;16:1132-1141 pubmed publisher
	Hayashi Y, Fujimura A, Kato K, Udagawa R, Hirota T, Kimura K. Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry. Sci Adv. 2018;4:eaap7777 pubmed publisher
	Goudarzi K, Nister M, Lindström M. mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. Cancer Biol Ther. 2014;15:1499-514 pubmed publisher
	Wang Y, Huang J, Castella M, Huntsman D, Taniguchi T. p53 is positively regulated by miR-542-3p. Cancer Res. 2014;74:3218-27 pubmed publisher
	Donati G, Peddigari S, Mercer C, Thomas G. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell Rep. 2013;4:87-98 pubmed publisher
	Chen W, Dittmer D. Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol. 2011;85:9495-505 pubmed publisher
	McMahon M, Ayllon V, Panov K, O Connor R. Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation. J Biol Chem. 2010;285:18309-18 pubmed publisher

product information

Product Type :

Antibody

Product Name :

RPL11 Monoclonal Antibody (3A4A7)

Catalog # :

37-3000

Quantity :

100 µg

Price :

US 500.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Western Blot: 1-3 µg/mL

Species :

Human, Non-human primate

Clone :

3A4A7

Isotype :

IgG1

Storage :

-20°C

Description :

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Immunogen :

fusing the mouse myeloma cell-line P3U1 with spleen cells of BALB/c mouse after immunization with human Laminin (1

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Western Blot: 1-3 µg/mL

Aliases :

2010203J19Rik; 60S ribosomal protein L11; cell growth-inhibiting protein 34; CLL-associated antigen KW-12; DBA7; GIG34; L11; Large ribosomal subunit protein uL5; ribosomal protein L11; RP11-223J15.3; RPL11; zgc:86748

more info or order :

Invitrogen product webpage