EphB4 Monoclonal Antibody (3D7G8) | Invitrogen 37-1800 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EphB4 Monoclonal Antibody (3D7G8)

catalog :

37-1800

quantity :

100 µg

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D7G8

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; loading ...; fig 1a	Stammes M, Prevoo H, Ter Horst M, Groot S, Van De Velde C, Chan A, et al. Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery. Int J Mol Sci. 2017;18: pubmed publisher
immunoprecipitation; human; fig 4	Dubois F, Leroy C, Simon V, Benistant C, Roche S. YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. Am J Cancer Res. 2015;5:1972-87 pubmed
western blot; human; 1:500	Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
western blot; human; 1:200	Li M, Zhao J, Qiao J, Song C, Zhao Z. EphB4 regulates the growth and migration of pancreatic cancer cells. Tumour Biol. 2014;35:6855-9 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Villarreal Calderon R, Luévano González A, Aragón Flores M, Zhu H, Yuan Y, Xiang Q, et al. Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis. Ann Diagn Pathol. 2014;18:129-35 pubmed publisher
immunohistochemistry - paraffin section; human; 10 ug/ml; fig 2	Guijarro Muñoz I, Sanchez A, Martínez Martínez E, Garcia J, Salas C, Provencio M, et al. Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab. Med Oncol. 2013;30:572 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1 western blot; human; 1:200; fig 3	Davalos V, Dopeso H, Castaño J, Wilson A, Vilardell F, Romero Gimenez J, et al. EPHB4 and survival of colorectal cancer patients. Cancer Res. 2006;66:8943-8 pubmed
	de Muijnck C, van Gorkom Y, van Duijvenvoorde M, Eghtesadi M, Dekker Ensink G, Bhairosingh S, et al. Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer. Pharmaceuticals (Basel). 2020;13: pubmed publisher
	Magić Ž, Sandström J, Pérez Tenorio G. Ephrin‑B2 inhibits cell proliferation and motility in vitro and predicts longer metastasis‑free survival in breast cancer. Int J Oncol. 2019;55:1275-1286 pubmed publisher
	Wimmer R, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505-510 pubmed publisher
	Pradeep S, Huang J, Mora E, Nick A, Cho M, Wu S, et al. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015;28:610-622 pubmed publisher
	Koolpe M, Burgess R, Dail M, Pasquale E. EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem. 2005;280:17301-11 pubmed

product information

Product Type :

Antibody

Product Name :

EphB4 Monoclonal Antibody (3D7G8)

Catalog # :

37-1800

Quantity :

100 µg

Price :

US 450

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 3-5 µg/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL

Species :

Human

Clone :

3D7G8

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Immunogen :

Recombinant protein derived from the C-terminal region of the human EphB4 protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 3-5 µg/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL

Aliases :

AI042935; Developmental kinase 2; EPH receptor B4; Ephb4; ephrin receptor EphB4; ephrin type-B receptor 4; Hepatoma transmembrane kinase; HTK; Mdk2; mDK-2; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11

more info or order :

Invitrogen product webpage