Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody | Invitrogen 36-8600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody

catalog :

36-8600

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - free floating section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; rat; 1:25,000; fig 7	Aquino N, Araujo Lopes R, Batista I, Henriques P, Poletini M, Franci C, et al. Hypothalamic Effects of Tamoxifen on Oestrogen Regulation of Luteinising Hormone and Prolactin Secretion in Female Rats. J Neuroendocrinol. 2016;28: pubmed publisher
	Morais M, Franco B, Holanda A, de Paula Simino L, Veras A, Torsoni M, et al. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. J Sleep Res. 2023;32:e13716 pubmed publisher
	Campideli Santana A, Gusmao D, Almeida F, Araujo Lopes R, Szawka R. Partial loss of arcuate kisspeptin neurons in female rats stimulates luteinizing hormone and decreases prolactin secretion induced by estradiol. J Neuroendocrinol. 2022;34:e13204 pubmed publisher
	Silva K, Aquino N, Gusmao D, Henriques P, Reis A, Szawka R. Reduced dopaminergic tone during lactation is permissive to the hypothalamic stimulus for suckling-induced prolactin release. J Neuroendocrinol. 2020;32:e12880 pubmed publisher
	Chitre N, Wood B, Ray A, Moniri N, Murnane K. Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased protein kinase activity in the striatum. Neuropharmacology. 2020;167:107976 pubmed publisher
	Yip S, Romano N, Gustafson P, Hodson D, Williams E, Kokay I, et al. Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons. Cell Rep. 2019;26:1787-1799.e5 pubmed publisher
	Portella A, Silveira P, Laureano D, Cardoso S, Bittencourt V, Noschang C, et al. Litter size reduction alters insulin signaling in the ventral tegmental area and influences dopamine-related behaviors in adult rats. Behav Brain Res. 2015;278:66-73 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody

Catalog # :

36-8600

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

Species :

Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen :

Synthetic phospho-peptide derived from the rat tyrosine hydroxylase (TH) protein (aa 40).

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

Aliases :

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase

more info or order :

Invitrogen product webpage