PEN2 Polyclonal Antibody | Invitrogen 36-7100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PEN2 Polyclonal Antibody

catalog :

36-7100

quantity :

50µg

price :

US 331

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 3d	Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher
western blot; human; fig 2	Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by Î³-secretase and reduce AÎ² production. Nat Commun. 2015;6:8876 pubmed publisher
western blot; mouse; fig 6a	Watanabe H, Iqbal M, Zheng J, Wines Samuelson M, Shen J. Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci. 2014;34:15912-22 pubmed publisher
western blot; mouse; fig 1	Watanabe H, Xia D, Kanekiyo T, Kelleher R, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012;32:5085-96 pubmed publisher
	Lauretti E, Pratico D. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease. Sci Rep. 2017;7:17134 pubmed publisher
	Li J, Chu J, Barrero C, Merali S, Pratico D. Homocysteine exacerbates ?-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol. 2014;75:851-63 pubmed publisher
	Heilig E, Gutti U, Tai T, Shen J, Kelleher R. Trans-dominant negative effects of pathogenic PSEN1 mutations on ?-secretase activity and A? production. J Neurosci. 2013;33:11606-17 pubmed publisher
	Matsushima T, Saito Y, Elliott J, Iijima Ando K, Nishimura M, Kimura N, et al. Membrane-microdomain localization of amyloid ?-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. J Biol Chem. 2012;287:19715-24 pubmed publisher
	Chu J, Pratico D. 5-lipoxygenase as an endogenous modulator of amyloid ? formation in vivo. Ann Neurol. 2011;69:34-46 pubmed publisher
	Puccio S, Chu J, Pratico D. Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence. PLoS ONE. 2011;6:e15163 pubmed publisher
	Wang R, Zhang Y, Sun P, Liu R, Zhang X, Zhang X, et al. Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol Cell Biol. 2006;26:1347-54 pubmed

product information

Product Type :

Antibody

Product Name :

PEN2 Polyclonal Antibody

Catalog # :

36-7100

Quantity :

50µg

Price :

US 331

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C

Description :

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

Immunogen :

Synthetic peptide derived from the N-terminal region of the human and mouse Pen-2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

MDS033, MSTP064, PEN-2, PEN2, gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033