Aurora B Polyclonal Antibody | Invitrogen 36-5200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Aurora B Polyclonal Antibody

catalog :

36-5200

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 5

Reference
Peng S, Luo Y, Chen L, Dai K, Wang Q. lncRNA ELFN1-AS1 enhances the progression of colon cancer by targeting miR-4270 to upregulate AURKB. Open Med (Wars). 2022;17:1999-2012 pubmed publisher
Tran T, Vu L, Nguyen H, Pham H, Do X, Than U, et al. Dual roles of oxostephanine as an Aurora kinase inhibitor and angiogenesis suppressor. Int J Mol Med. 2022;50: pubmed publisher
Nandi D, Cheema P, Singal A, Bharti H, Nag A. Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1. Front Oncol. 2021;11:751271 pubmed publisher
Antao A, Kaushal K, Das S, Singh V, Suresh B, Kim K, et al. USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B. Int J Mol Sci. 2021;22: pubmed publisher
Hariharan N, Quijada P, Mohsin S, Joyo A, Samse K, Monsanto M, et al. Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging. J Am Coll Cardiol. 2015;65:133-47 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Aurora B Polyclonal Antibody

Catalog # :

36-5200

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C

Description :

The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

Immunogen :

Synthetic peptide derived from the N-terminal region of the human Aurora B protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 ug/mL

Aliases :

Aik2; AIM1; AIM-1; AIRK2; AL022959; ARK2; ARK-2; AurB; AURKB; aurkb-sv1; aurkb-sv2; aurora 1; aurora- and IPL1-like midbody-associated protein 1; aurora B; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK1; STK-1; Stk12; STK12; AIK2; AIM1; ARK2; IPL1; AIM-1; STK5