product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Connexin 36 Polyclonal Antibody
catalog :
36-4600
quantity :
100 ug
price :
US 471.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
mudpuppy, human, mouse, zebrafish , cat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; zebrafish ; loading ...; fig 3c
Brunal A, Clark K, Ma M, Woods I, Pan Y. Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity. Front Mol Neurosci. 2020;13:587978 pubmed publisher
  • immunohistochemistry; cat; 1:100; loading ...; fig 1c
Fukuda T. Structural organization of the dendritic reticulum linked by gap junctions in layer 4 of the visual cortex. Neuroscience. 2017;340:76-90 pubmed publisher
  • immunohistochemistry; mudpuppy; fig 1
Lavrov I, Fox L, Shen J, Han Y, Cheng J. Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus). PLoS ONE. 2016;11:e0152650 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig 8
Farnsworth N, Walter R, Hemmati A, Westacott M, Benninger R. Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ. J Biol Chem. 2016;291:3184-96 pubmed publisher
Michel J, Grivette M, Harshfield A, Huynh L, Komons A, Loomis B, et al. Electrical synapse structure requires distinct isoforms of a postsynaptic scaffold. PLoS Genet. 2023;19:e1011045 pubmed publisher
Michel J, Lasseigne A, Marsh A, Miller A. The disconnect2 mutation disrupts the tjp1b gene that is required for electrical synapse formation. MicroPubl Biol. 2022;2022: pubmed publisher
Adams M, Dwulet J, Briggs J, Reissaus C, Jin E, Szulczewski J, et al. Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells. elife. 2021;10: pubmed publisher
Banerjee S, Wang Q, Tang G, So C, Shan S, Li K, et al. Functional connexin35 increased in the myopic chicken retina. Vis Neurosci. 2021;38:E008 pubmed publisher
Tetenborg S, Wang H, Nemitz L, Depping A, Espejo A, Aseervatham J, et al. Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro. Sci Rep. 2020;10:18378 pubmed publisher
Banerjee S, Wang Q, Zhao F, Tang G, So C, Tse D, et al. Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina. Front Cell Neurosci. 2020;14:124 pubmed publisher
Ixmatlahua D, Vizcarra B, Gómez Lira G, Romero Maldonado I, Ortiz F, Rojas Piloni G, et al. Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions. J Neurosci. 2020;40:4661-4672 pubmed publisher
Pasquale R, Umino Y, Solessio E. Rod Photoreceptors Signal Fast Changes in Daylight Levels Using a Cx36-Independent Retinal Pathway in Mouse. J Neurosci. 2020;40:796-810 pubmed publisher
Yadav S, Tetenborg S, Dedek K. Gap Junctions in A8 Amacrine Cells Are Made of Connexin36 but Are Differently Regulated Than Gap Junctions in AII Amacrine Cells. Front Mol Neurosci. 2019;12:99 pubmed publisher
Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, et al. Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Front Neurosci. 2018;12:894 pubmed publisher
Tetenborg S, Yadav S, Hormuzdi S, Monyer H, Janssen Bienhold U, Dedek K. Differential Distribution of Retinal Ca2+/Calmodulin-Dependent Kinase II (CaMKII) Isoforms Indicates CaMKII-β and -δ as Specific Elements of Electrical Synapses Made of Connexin36 (Cx36). Front Mol Neurosci. 2017;10:425 pubmed publisher
Marsh A, Michel J, Adke A, Heckman E, Miller A. Asymmetry of an Intracellular Scaffold at Vertebrate Electrical Synapses. Curr Biol. 2017;27:3561-3567.e4 pubmed publisher
Miller A, Whitebirch A, Shah A, Marsden K, Granato M, O BRIEN J, et al. A genetic basis for molecular asymmetry at vertebrate electrical synapses. elife. 2017;6: pubmed publisher
Knoflach D, Schicker K, Glösmann M, Koschak A. Gain-of-function nature of Cav1.4 L-type calcium channels alters firing properties of mouse retinal ganglion cells. Channels (Austin). 2015;9:298-306 pubmed publisher
Rubio M, Nagy J. Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses. Neuroscience. 2015;303:604-29 pubmed publisher
Shah A, Davey C, Whitebirch A, Miller A, Moens C. Rapid reverse genetic screening using CRISPR in zebrafish. Nat Methods. 2015;12:535-40 pubmed publisher
Miller A, Voelker L, Shah A, Moens C. Neurobeachin is required postsynaptically for electrical and chemical synapse formation. Curr Biol. 2015;25:16-28 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Connexin 36 Polyclonal Antibody
Catalog # :
36-4600
Quantity :
100 ug
Price :
US 471.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
ELISA: 0.1-1 ug/mL, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1-3 ug/mL
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20 C
Description :
Connexin-36 (CX36), is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Connexins associate in groups of 6 and are organized radially around a central pore to form connexons. Each gap junction intercellular channel is formed by the conjunction of 2 connexons. Mutations in connexin-encoding genes can lead to functional and developmental abnormalities.
Immunogen :
Synthetic peptide derived from the C-terminal region of the human Connexin 36 protein.
Format :
Liquid
Applications w/Dilutions :
ELISA: 0.1-1 ug/mL, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1-3 ug/mL
Aliases :
connexin 36; connexin36; connexin-36; cx36; Gap junction alpha-9 protein; gap junction delta-2 protein; gap junction membrane channel protein alpha 9; gap junction protein delta 2; gap junction protein, alpha 9; gap junction protein, delta 2; gap junction protein, delta 2, 36kDa; GJA10; Gja9; GJD2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA