ZO-3 Polyclonal Antibody | Invitrogen 36-4100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-3 Polyclonal Antibody

catalog :

36-4100

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

citations: 8

Reference
Yang Y, Fan X, Ji Y, Li J, Dai Z, Wu Z. Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling. Anim Nutr. 2022;8:1-9 pubmed publisher
Sugawara T, Furuse K, Otani T, Wakayama T, Furuse M. Angulin-1 seals tricellular contacts independently of tricellulin and claudins. J Cell Biol. 2021;220: pubmed publisher
Jia H, Zhang Y, Si X, Jin Y, Jiang D, Dai Z, et al. Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes. Nutrients. 2021;13: pubmed publisher
Tan B, Yatim S, Peng S, Gunaratne J, Hunziker W, Ludwig A. The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions. Curr Biol. 2020;30:2791-2804.e6 pubmed publisher
Otani T, Nguyen T, Tokuda S, Sugihara K, Sugawara T, Furuse K, et al. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J Cell Biol. 2019;218:3372-3396 pubmed publisher
Wang L, Wrobel J, Xie L, Li D, Zurlo G, Shen H, et al. Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Cell Chem Biol. 2018;25:619-633.e5 pubmed publisher
Vasileva E, Sluysmans S, Bochaton Piallat M, Citi S. Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions. Ann N Y Acad Sci. 2017;1405:160-176 pubmed publisher
Tokuda S, Furuse M. Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS ONE. 2015;10:e0119869 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZO-3 Polyclonal Antibody

Catalog # :

36-4100

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1 ug/mL, Immunoprecipitation: 1-2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Canine, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

ZO-3 is a member of the membrane associated guanylate kinse (MAGUK) family and are considered tight junction-associated proteins. Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. ZO-3 is believed to have both structural and signaling roles, and is characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.

Immunogen :

Synthetic peptide derived from the C-terminal region of the human ZO-3 protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1 ug/mL, Immunoprecipitation: 1-2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

tight junction protein 3; tight junction protein 3 (zona occludens 3); tight junction protein ZO-3; TJP3; TJP-3; ZO3; ZO-3; Zona occludens protein 3; zonula occludens protein 3