| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s8a
| Zhao Q, Dai W, Chen H, Jacobs R, Zlokovic B, Lund B, et al. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proc Natl Acad Sci U S A. 2022;119:e2113310119 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 1c
| Wei X, Meel M, Breur M, Bugiani M, Hulleman E, Phoenix T. Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas. Acta Neuropathol Commun. 2021;9:142 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig s2-1c
| Orsenigo F, Conze L, Jauhiainen S, Corada M, Lazzaroni F, Malinverno M, et al. Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution. elife. 2020;9: pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5e
| Engelbrecht E, Lévesque M, He L, Vanlandewijck M, Nitzsche A, Niazi H, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. elife. 2020;9: pubmed publisher |
- immunohistochemistry; mouse; 1:400; loading ...; fig 1a
| Cho C, Wang Y, Smallwood P, Williams J, Nathans J. Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. elife. 2019;8: pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 1b
| Wang Y, Sabbagh M, Gu X, Rattner A, Williams J, Nathans J. Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. elife. 2019;8: pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 1j
| Louveau A, Herz J, Alme M, Salvador A, Dong M, Viar K, et al. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. 2018;21:1380-1391 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 3h
| Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 3g
| Cho C, Smallwood P, Nathans J. Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017;95:1056-1073.e5 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 6k
| Andreone B, Chow B, Tata A, Lacoste B, Ben Zvi A, Bullock K, et al. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017;94:581-594.e5 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:400; loading ...; fig s4a
| Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5b
| Swanson P, Hart G, Russo M, Nayak D, Yazew T, Pena M, et al. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 2016;12:e1006022 pubmed publisher |
- immunohistochemistry; human; fig 1
- immunohistochemistry; mouse; fig 1
| Lewandowski S, Nilsson I, Fredriksson L, Lönnerberg P, Muhl L, Zeitelhofer M, et al. Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration. Acta Neuropathol. 2016;131:453-64 pubmed publisher |
- immunohistochemistry; mouse; fig 5
| Zhou Y, Williams J, Smallwood P, Nathans J. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE. 2015;10:e0143650 pubmed publisher |
- immunocytochemistry; mouse
| Hyun Jo D, Lee R, Hyoung Kim J, Oh Jun H, Geol Lee T, Hun Kim J. Real-time estimation of paracellular permeability of cerebral endothelial cells by capacitance sensor array. Sci Rep. 2015;5:11014 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; fig e5
| Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-41 pubmed publisher |
- immunohistochemistry; mouse
| Rattner A, Wang Y, Zhou Y, Williams J, Nathans J. The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling. Invest Ophthalmol Vis Sci. 2014;55:8614-25 pubmed publisher |
- immunohistochemistry; mouse; fig 3
| Zhou Y, Wang Y, TISCHFIELD M, Williams J, Smallwood P, Rattner A, et al. Canonical WNT signaling components in vascular development and barrier formation. J Clin Invest. 2014;124:3825-46 pubmed publisher |
| Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498:492-6 pubmed publisher |
- immunohistochemistry; mouse; fig S3
| Wang Y, Rattner A, Zhou Y, Williams J, Smallwood P, Nathans J. Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell. 2012;151:1332-44 pubmed publisher |
| Wang J, Rattner A, Nathans J. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution. elife. 2023;12: pubmed publisher |
| Oue H, Yamazaki Y, Qiao W, Yuanxin C, Ren Y, Kurti A, et al. LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4. JCI Insight. 2023;8: pubmed publisher |
| Le T, Nguyen T, Kalailingam P, Nguyen Y, Sukumar V, Tan C, et al. Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock. Cell Rep. 2022;40:111208 pubmed publisher |
| Greene C, Campbell M. Immunohistochemical Analysis of Tight Junction Proteins. Methods Mol Biol. 2022;2492:307-314 pubmed publisher |
| Ayloo S, Lazo C, Sun S, Zhang W, Cui B, Gu C. Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier. Neuron. 2022;110:1641-1655.e6 pubmed publisher |
| Boyé K, Geraldo L, Furtado J, Pibouin Fragner L, Poulet M, Kim D, et al. Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022;13:1169 pubmed publisher |
| Engelbrecht E, Metzler M, Sandell L. Retinoid signaling regulates angiogenesis and blood-retinal barrier integrity in neonatal mouse retina. Microcirculation. 2022;29:e12752 pubmed publisher |
| Song X, Cui Y, Wang Y, Zhang Y, He Q, Yu Z, et al. Genome Editing with AAV-BR1-CRISPR in Postnatal Mouse Brain Endothelial Cells. Int J Biol Sci. 2022;18:652-660 pubmed publisher |
| Ivanova E, Corona C, Eleftheriou C, Stout R, K xf6 rbelin J, Sagdullaev B. AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43. J Comp Neurol. 2022;530:1302-1317 pubmed publisher |
| Yu R, Kim N, Li Y, Jeong J, Park S, Zhou B, et al. Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. Transl Stroke Res. 2022;13:142-159 pubmed publisher |
| Amiri P, DeCastro J, Littig J, Lu H, Liu C, Conboy I, et al. Erythrocytes, a New Contributor to Age-Associated Loss of Blood-Brain Barrier Integrity. Adv Sci (Weinh). 2021;8:e2101912 pubmed publisher |
| Holzner S, Bromberger S, Wenzina J, Neumüller K, Holper T, Petzelbauer P, et al. Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells. J Cell Sci. 2021;: pubmed publisher |
| Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher |
| Dani N, Herbst R, McCabe C, Green G, Kaiser K, Head J, et al. A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021;184:3056-3074.e21 pubmed publisher |
| Marquez Curtis L, Bokenfohr R, McGann L, Elliott J. Cryopreservation of human cerebral microvascular endothelial cells and astrocytes in suspension and monolayers. PLoS ONE. 2021;16:e0249814 pubmed publisher |
| Eustaquio Do Imperio G, Lye P, Bloise E, Matthews S. Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells. Tissue Barriers. 2021;9:1860616 pubmed publisher |
| Yang J, Ma K, Zhang C, Liu Y, Liang F, Hu W, et al. Burns Impair Blood-Brain Barrier and Mesenchymal Stem Cells Can Reverse the Process in Mice. Front Immunol. 2020;11:578879 pubmed publisher |
| Cottarelli A, Corada M, Beznoussenko G, Mironov A, Globisch M, Biswas S, et al. Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development. 2020;147: pubmed publisher |
| Ittner C, Burek M, Störk S, Nagai M, Förster C. Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro. Front Cardiovasc Med. 2020;7:73 pubmed publisher |
| Lehmann G, Hanke Gogokhia C, Hu Y, Bareja R, Salfati Z, Ginsberg M, et al. Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid. J Exp Med. 2020;217: pubmed publisher |
| Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, et al. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020;52:779-793.e7 pubmed publisher |
| Yu Z, Zeng J, Wang J, Cui Y, Song X, Zhang Y, et al. Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. Cardiovasc Res. 2021;117:533-546 pubmed publisher |
| Wang Y, Smallwood P, Williams J, Nathans J. A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Hum Mol Genet. 2020;29:1121-1131 pubmed publisher |
| Lux T, Hu X, Ben Kraiem A, Blum R, Chen J, Rittner H. Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats. Int J Mol Sci. 2019;21: pubmed publisher |
| Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, et al. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019;25:754-767.e9 pubmed publisher |
| Lee S, Chung M, Lee S, Jeon N. 3D brain angiogenesis model to reconstitute functional human blood-brain barrier in vitro. Biotechnol Bioeng. 2020;117:748-762 pubmed publisher |
| Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann Y, Kanekiyo T, et al. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arterioscler Thromb Vasc Biol. 2020;40:128-144 pubmed publisher |
| Meel M, Guillen Navarro M, de Gooijer M, Metselaar D, Waranecki P, Breur M, et al. MEK/MELK inhibition and blood-brain barrier-deficiencies in atypical teratoid/rhabdoid tumors. Neuro Oncol. 2019;: pubmed publisher |
| Suwannasual U, Lucero J, Davis G, McDonald J, Lund A. Mixed Vehicle Emissions Induces Angiotensin II and Cerebral Microvascular Angiotensin Receptor Expression in C57Bl/6 Mice and Promotes Alterations in Integrity in a Blood-Brain Barrier Coculture Model. Toxicol Sci. 2019;170:525-535 pubmed publisher |
| Niu J, Tsai H, Hoi K, Huang N, Yu G, Kim K, et al. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019;22:709-718 pubmed publisher |
| Ivanova E, Alam N, Prusky G, Sagdullaev B. Blood-retina barrier failure and vision loss in neuron-specific degeneration. JCI Insight. 2019;5: pubmed publisher |
| Patel M, Behar A, Silasi R, Regmi G, Sansam C, Keshari R, et al. Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. J Am Heart Assoc. 2018;7:e010690 pubmed publisher |
| Wang Y, Cho C, Williams J, Smallwood P, Zhang C, Junge H, et al. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci U S A. 2018;115:E11827-E11836 pubmed publisher |
| Akla N, Viallard C, Popovic N, Lora Gil C, Sapieha P, Larrivee B. BMP (Bone Morphogenetic Protein) 9/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher |
| Zbesko J, Nguyen T, Yang T, Frye J, Hussain O, Hayes M, et al. Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts. Neurobiol Dis. 2018;112:63-78 pubmed publisher |
| Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017;7:5590 pubmed publisher |
| Ivanova E, Kovacs Oller T, Sagdullaev B. Vascular Pericyte Impairment and Connexin43 Gap Junction Deficit Contribute to Vasomotor Decline in Diabetic Retinopathy. J Neurosci. 2017;37:7580-7594 pubmed publisher |
| Chow B, Gu C. Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation. Neuron. 2017;93:1325-1333.e3 pubmed publisher |
| Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro Oonuma T, Hwang Y, et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. 2017;2:e90905 pubmed publisher |
| Paul D, Baena V, Ge S, Jiang X, Jellison E, Kiprono T, et al. Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. J Neuroinflammation. 2016;13:292 pubmed |
| Zhou Y, Nathans J. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev Cell. 2014;31:248-56 pubmed publisher |
| Wu H, Luo J, Yu H, Rattner A, Mo A, Wang Y, et al. Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease. Neuron. 2014;81:103-19 pubmed publisher |
| Chen J, Stahl A, Krah N, Seaward M, Dennison R, Sapieha P, et al. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011;124:1871-81 pubmed publisher |
