Human ApoE4 Recombinant Protein, PeproTech | Invitrogen 350-04-500UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human ApoE4 Recombinant Protein, PeproTech

catalog :

350-04-500UG

quantity :

500 ug

price :

US 226.00

citations: 7

Reference
Wang C, Lu J, Sha X, Qiu Y, Chen H, Yu Z. TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia. Exp Mol Med. 2023;55:347-363 pubmed publisher
Alam S, Wang F, Qian H, Kulka M. Apolipoprotein C3 facilitates internalization of cationic lipid nanoparticles into bone marrow-derived mouse mast cells. Sci Rep. 2023;13:431 pubmed publisher
Ramakrishna S, Jhaveri V, Konings S, Nawalpuri B, Chakraborty S, Holst B, et al. APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis. J Neurosci. 2021;41:8686-8709 pubmed publisher
Zhang L, Zhang K, Zhang J, Zhu J, Xi Q, Wang H, et al. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization. Nat Commun. 2021;12:4300 pubmed publisher
Chikazawa M, Yoshitake J, Lim S, Iwata S, Negishi L, Shibata T, et al. Glycolaldehyde is an endogenous source of lysine N-pyrrolation. J Biol Chem. 2020;295:7697-7709 pubmed publisher
Veiga S, Rodríguez Martín A, Garcia Ribas G, Arribas I, Menacho Román M, Calero M. Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers. Sci Rep. 2020;10:2138 pubmed publisher
Rungta R, Choi H, Lin P, Ko R, Ashby D, Nair J, et al. Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain. Mol Ther Nucleic Acids. 2013;2:e136 pubmed publisher

product information

Product Type :

Protein

Product Name :

Human ApoE4 Recombinant Protein, PeproTech

Catalog # :

350-04-500UG

Quantity :

500 ug

Price :

US 226.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

Functional Assay: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer's disease.

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

APO-E; Apolipoprotein E3