TTK Monoclonal Antibody (N1) | Invitrogen 35-9100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TTK Monoclonal Antibody (N1)

catalog :

35-9100

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1b	Faisal A, Mak G, Gurden M, Xavier C, Anderhub S, Innocenti P, et al. Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. Br J Cancer. 2017;116:1166-1176 pubmed publisher
immunocytochemistry; human	Naud S, Westwood I, Faisal A, Sheldrake P, Bavetsias V, Atrash B, et al. Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem. 2013;56:10045-65 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Niittymäki I, Gylfe A, Laine L, Laakso M, Lehtonen H, Kondelin J, et al. High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint. Carcinogenesis. 2011;32:305-11 pubmed publisher
	Anderhub S, Mak G, Gurden M, Faisal A, Drosopoulos K, Walsh K, et al. High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Mol Cancer Ther. 2019;18:1696-1707 pubmed publisher
	Fisk H, Mattison C, Winey M. Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. Proc Natl Acad Sci U S A. 2003;100:14875-80 pubmed

product information

Product Type :

Antibody

Product Name :

TTK Monoclonal Antibody (N1)

Catalog # :

35-9100

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 2 ug/mL

Species :

Human

Clone :

Isotype :

IgG1

Storage :

-20 C

Description :

TTK is a serine/threonine kinase closely related to SPK1, PIM 1 and CDC2 serine/threonine kinases. TTK is a dual-specificity kinase, which can also phosphorylate tyrosine. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. TTK encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.

Immunogen :

His6-tagged human Mps1 recombinant protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 2 ug/mL

Aliases :

AL022661; cancer/testis antigen 96; CT96; Dual specificity protein kinase TTK; esk; Esk1; monopolar spindle 1 kinase; monopolar spindle 1-like 1; MPH1; MPS1; MPS1L1; OTTHUMP00000016778; OTTHUMP00000220743; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; PYT; TTK; Ttk protein kinase

more info or order :

Invitrogen product webpage