alpha Synuclein Monoclonal Antibody (Syn 505) | Invitrogen 35-8300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha Synuclein Monoclonal Antibody (Syn 505)

catalog :

35-8300

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Syn 505

reactivity :

grey mouse lemur, human, mouse

application :

western blot, ELISA, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:1000; loading ...; fig 6j	Wu Q, Yang X, Zhang Y, Zhang L, Feng L. Chronic mild stress accelerates the progression of Parkinson's disease in A53T ?-synuclein transgenic mice. Exp Neurol. 2016;285:61-71 pubmed publisher
immunohistochemistry; grey mouse lemur; 1:100; fig 2b	Canron M, Perret M, Vital A, Bezard E, Dehay B. Age-dependent ?-synuclein aggregation in the Microcebus murinus lemur primate. Sci Rep. 2012;2:910 pubmed publisher
	Masone A, Zucchelli C, Caruso E, Lavigna G, Era xf1 a H, Giachin G, et al. A tetracationic porphyrin with dual anti-prion activity. iScience. 2023;26:107480 pubmed publisher
	Reynolds W, Malle E, Maki R. Thiocyanate Reduces Motor Impairment in the hMPO-A53T PD Mouse Model While Reducing MPO-Oxidation of Alpha Synuclein in Enlarged LYVE1/AQP4 Positive Periventricular Glymphatic Vessels. Antioxidants (Basel). 2022;11: pubmed publisher
	Prieto Huarcaya S, Drobny A, Marques A, Di Spiezio A, Dobert J, Balta D, et al. Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. Autophagy. 2022;18:1127-1151 pubmed publisher
	Sacchini S, Herr xe1 ez P, Arbelo M, Espinosa de los Monteros A, Sierra E, Rivero M, et al. Methodology and Neuromarkers for Cetaceans' Brains. Vet Sci. 2022;9: pubmed publisher
	Maki R, Holzer M, Motamedchaboki K, Malle E, Masliah E, Marsche G, et al. Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment. Free Radic Biol Med. 2019;141:115-140 pubmed publisher
	Duda J, Giasson B, Mabon M, Lee V, Trojanowski J. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol. 2002;52:205-10 pubmed

product information

Product Type :

Antibody

Product Name :

alpha Synuclein Monoclonal Antibody (Syn 505)

Catalog # :

35-8300

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

Syn 505

Isotype :

IgG1

Storage :

-20 C

Description :

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Immunogen :

Recombinant full-length oxidized human alpha-Synuclein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)

more info or order :

Invitrogen product webpage