COX1 Monoclonal Antibody (COX 111) | Invitrogen 35-8100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

COX1 Monoclonal Antibody (COX 111)

catalog :

35-8100

quantity :

100 µg

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

COX 111

reactivity :

human, mouse, rat, domestic sheep

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 1g	Cogliati S, Calvo E, Loureiro M, Guaras A, Nieto Arellano R, Garcia Poyatos C, et al. Mechanism of super-assembly of respiratory complexes III and IV. Nature. 2016;539:579-582 pubmed publisher
immunocytochemistry; human western blot; human	Yuan C, Smith W. A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus. J Biol Chem. 2015;290:5606-20 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Taskin S, Dunder I, Erol E, Taşkin E, Kiremitci S, Oztuna D, et al. Roles of E-cadherin and cyclooxygenase enzymes in predicting different survival patterns of optimally cytoreduced serous ovarian cancer patients. Asian Pac J Cancer Prev. 2012;13:5715-9 pubmed
western blot; human; fig 4	Bronger H, Kraeft S, Schwarz Boeger U, Cerny C, Stöckel A, Avril S, et al. Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer. Breast Cancer Res. 2012;14:R30 pubmed
immunocytochemistry; human; fig 4	Lundström S, Levänen B, Nording M, Klepczynska Nyström A, Sköld M, Haeggstrom J, et al. Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PLoS ONE. 2011;6:e23864 pubmed publisher
western blot; human; fig 7	Sato S, Trackman P, Maki J, Myllyharju J, Kirsch K, Sonenshein G. The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol. 2011;31:2683-95 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400; fig 1	Ali Fehmi R, Semaan A, Sethi S, Arabi H, Bandyopadhyay S, Hussein Y, et al. Molecular typing of epithelial ovarian carcinomas using inflammatory markers. Cancer. 2011;117:301-9 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; tbl 1	Ketabchi S, Massi D, Ficarra G, Rubino I, Franchi A, Paglierani M, et al. Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis. Oral Dis. 2007;13:419-25 pubmed
	Putri J, Bhargava P, Dhanjal J, Yaguchi T, Sundar D, Kaul S, et al. Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers. J Exp Clin Cancer Res. 2019;38:499 pubmed publisher
	d Uscio L, Katusic Z. Vascular phenotype of amyloid precursor protein-deficient mice. Am J Physiol Heart Circ Physiol. 2019;316:H1297-H1308 pubmed publisher
	Chuang Y, Chen S, Hsu C, Chen S, Chen N, Jou S. Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway. Int J Mol Sci. 2019;20: pubmed publisher
	Bronger H, Singer J, WindmÃ¼ller C, Reuning U, Zech D, Delbridge C, et al. CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer. Br J Cancer. 2016;115:553-63 pubmed publisher
	Jiang Y, Turgeon D, Wright B, Sidahmed E, Ruffin M, Brenner D, et al. Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer. Eur J Cancer Prev. 2013;22:455-60 pubmed publisher
	Hurisso B, Lovelock K, Licence P. Amino acid-based ionic liquids: using XPS to probe the electronic environment via binding energies. Phys Chem Chem Phys. 2011;13:17737-48 pubmed publisher

product information

Product Type :

Antibody

Product Name :

COX1 Monoclonal Antibody (COX 111)

Catalog # :

35-8100

Quantity :

100 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Ovine, Rat

Applications :

ELISA: Assay-dependent, Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Ovine, Rat

Clone :

COX 111

Isotype :

IgG2b, kappa

Storage :

-20°C

Description :

PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

Immunogen :

Ram testes.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

COI; COX1; Cox-1; COX3; Cox-3; COXI; cyclooxygenase 3; cyclooxygenase precursor (EC 1.14.99.1); cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; Mtco1; mt-Co1; P PGG/HS; PCOX1; PES-1; PGG/HS; PGH synthase 1; PGHS1; Pghs-1; PHS 1; PHS1; prostaglandin endoperoxide synthase; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin G/H synthase precursor (EC 1.14.99.1); prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; unnamed protein product

more info or order :

Invitrogen product webpage