MUC4 Monoclonal Antibody (1G8) | Invitrogen 35-4900 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MUC4 Monoclonal Antibody (1G8)

catalog :

35-4900

quantity :

100 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1G8

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rat; 1:200; fig 1b	Leng Y, Yi M, Fan J, Bai Y, Ge Q, Yao G. Effects of acute intra-abdominal hypertension on multiple intestinal barrier functions in rats. Sci Rep. 2016;6:22814 pubmed publisher
immunohistochemistry; human; 1:50; fig 6	Ertoy Baydar D, Kosemehmetoglu K, Aydin O, Bridge J, Buyukeren B, Aki F. Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature. Diagn Pathol. 2015;10:186 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; tbl 2	Dhir A, Dhir S, Proudfoot N, Jopling C. Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs. Nat Struct Mol Biol. 2015;22:319-27 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; tbl 2	Koo D, Lee H, Ahn J, Yoon D, Kim S, Gong G, et al. Tau and PTEN status as predictive markers for response to trastuzumab and paclitaxel in patients with HER2-positive breast cancer. Tumour Biol. 2015;36:5865-71 pubmed publisher
immunocytochemistry; human; fig 5	Kim C, Galloway J, Lee K, Searson P. Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers. Bioconjug Chem. 2014;25:1893-901 pubmed publisher
immunohistochemistry; human	Noda Y, Fujita N, Kobayashi G, Ito K, Horaguchi J, Hashimoto S, et al. Prospective randomized controlled study comparing cell block method and conventional smear method for bile cytology. Dig Endosc. 2013;25:444-52 pubmed publisher
immunohistochemistry; rat; fig 4	Yeh C, Lin K, Chen T, Wu R, Tsao L, Chen Y, et al. Characterization of a novel rat cholangiocarcinoma cell culture model-CGCCA. World J Gastroenterol. 2011;17:2924-32 pubmed publisher
ELISA; human; fig 1	Bae C, Kim J, Ye S, Song S, Kim Y, Park S, et al. AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells. Biochem Biophys Res Commun. 2011;409:669-74 pubmed publisher
ELISA; human; fig 2	Woo H, Yoo W, Bae C, Song S, Kim Y, Park S, et al. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. Exp Lung Res. 2010;36:262-9 pubmed publisher
immunohistochemistry; human; 1:1500; fig 2 immunohistochemistry; rat; 1:1500; fig 1	Yeh C, Pang S, Wu R, Chen T, Jan Y, Chen M. Prognostic value of MUC4 for mass-forming intrahepatic cholangiocarcinoma after hepatectomy. Oncol Rep. 2009;21:49-56 pubmed
	Hu C, Huang C, Hsu M, Chien H, Wu P, Chen Y, et al. Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for PanIN Initiation. Adv Sci (Weinh). 2023;10:e2301240 pubmed publisher
	Yang M, Lennikov A, Chang K, Ashok A, Lee C, Cho K, et al. Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface. BMC Ophthalmol. 2022;22:490 pubmed publisher
	Shi A, Fan Z, Ma K, Jiang Y, Wang L, Zhang K, et al. Isolation and characterization of adult mammary stem cells from breast cancer-adjacent tissues. Oncol Lett. 2017;14:2894-2902 pubmed publisher
	Wang W, Yin L, Gonzalez Malerva L, Wang S, Yu X, Eaton S, et al. In situ drug-receptor binding kinetics in single cells: a quantitative label-free study of anti-tumor drug resistance. Sci Rep. 2014;4:6609 pubmed publisher
	Zhu Y, Zhang J, Liang W, Zhu R, Wang B, Miao Y, et al. Pancreatic cancer counterattack: MUC4 mediates Fas-independent apoptosis of antigen-specific cytotoxic T lymphocyte. Oncol Rep. 2014;31:1768-76 pubmed publisher
	Khanh D, Mekata E, Mukaisho K, Sugihara H, Shimizu T, Shiomi H, et al. Transmembrane mucin MUC1 overexpression and its association with CD10? myeloid cells, transforming growth factor-?1 expression, and tumor budding grade in colorectal cancer. Cancer Sci. 2013;104:958-64 pubmed publisher
	Chen S, Dallas M, Balzer E, Konstantopoulos K. Mucin 16 is a functional selectin ligand on pancreatic cancer cells. FASEB J. 2012;26:1349-59 pubmed publisher
	Westgaard A, Schjølberg A, Cvancarova M, Eide T, Clausen O, Gladhaug I. Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 2009;54:337-47 pubmed publisher
	Wilson N, Robinson L, Donnet A, Bovetto L, Packer N, Karlsson N. Glycoproteomics of milk: differences in sugar epitopes on human and bovine milk fat globule membranes. J Proteome Res. 2008;7:3687-96 pubmed publisher
	Hori Y, Spurr Michaud S, Russo C, ARGUESO P, Gipson I. Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest Ophthalmol Vis Sci. 2004;45:114-22 pubmed

product information

Product Type :

Antibody

Product Name :

MUC4 Monoclonal Antibody (1G8)

Catalog # :

35-4900

Quantity :

100 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Clone :

1G8

Isotype :

IgG1

Storage :

-20 C

Description :

Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases - Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.

Immunogen :

Rat ASGP-2

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

4933405I11Rik; Ascites sialoglycoprotein; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; ASGP; ASGP1; ASGP-1; ASGP-2; HSA276359; MUC4; MUC-4; mucin 4; mucin 4, ASGP; mucin 4, cell surface associated; mucin 4, tracheobronchial; Mucin4; mucin-4; Mucin-4 alpha chain; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; pre-sialomucin complex; Psmc; sialomucin ascites sialoglycoprotein-1; sialomucin complex; testis mucin; Tracheobronchial mucin

more info or order :

Invitrogen product webpage