ALK Monoclonal Antibody (4C5B8) | Invitrogen 35-4300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ALK Monoclonal Antibody (4C5B8)

catalog :

35-4300

quantity :

100 µg

price :

US 425.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4C5B8

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 4	Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed publisher
immunocytochemistry; human; fig 1 immunohistochemistry; human; fig 1 western blot; human; fig 1	Ceccon M, Merlo M, Mologni L, Poggio T, Varesio L, Menotti M, et al. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene. 2016;35:3854-3865 pubmed publisher
western blot; human; fig 1	Cheng M, Quail M, Gingrich D, Ott G, Lu L, Wan W, et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2012;11:670-9 pubmed publisher
immunocytochemistry; mouse immunocytochemistry; human western blot; human	Piva R, Chiarle R, Manazza A, Taulli R, Simmons W, Ambrogio C, et al. Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood. 2006;107:689-97 pubmed
	Menotti M, Ambrogio C, Cheong T, Pighi C, Mota I, Cassel S, et al. Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma. Nat Med. 2019;25:130-140 pubmed publisher
	Shi B, Vishwamitra D, Granda J, Whitton T, Shi P, Amin H. Molecular and functional characterizations of the association and interactions between nucleophosmin-anaplastic lymphoma kinase and type I insulin-like growth factor receptor. Neoplasia. 2013;15:669-83 pubmed
	Cui Y, Kerby A, McDuff F, Ye H, Turner S. NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner. Blood. 2009;113:5217-27 pubmed publisher
	Wan W, Albom M, Lu L, Quail M, Becknell N, Weinberg L, et al. Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells. Blood. 2006;107:1617-23 pubmed

product information

Product Type :

Antibody

Product Name :

ALK Monoclonal Antibody (4C5B8)

Catalog # :

35-4300

Quantity :

100 µg

Price :

US 425.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

4C5B8

Isotype :

IgG1

Storage :

-20°C

Description :

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.

Immunogen :

Recombinant protein derived from the human ALK protein.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

Alk; ALK tyrosine kinase receptor; anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK

more info or order :

Invitrogen product webpage