| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - frozen section; human; 1:150; loading ...; fig s1a
- immunohistochemistry - frozen section; mouse; 1:150; loading ...; fig s1b
- immunohistochemistry knockout validation; zebrafish ; 1:150; loading ...; fig 1b
| Li Y, Wang C, Zhang L, Chen B, Mo Y, Zhang J. Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids Barriers CNS. 2022;19:40 pubmed publisher |
- immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig 7a
| Sasson E, Anzi S, Bell B, Yakovian O, Zorsky M, Deutsch U, et al. Nano-scale architecture of blood-brain barrier tight-junctions. elife. 2021;10: pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3a
| Faulhaber L, Phuong A, Hartsuyker K, Cho Y, Mand K, Harper S, et al. Brain capillary obstruction during neurotoxicity in a mouse model of anti-CD19 chimeric antigen receptor T-cell therapy. Brain Commun. 2022;4:fcab309 pubmed publisher |
- immunohistochemistry; rat; 1:200; loading ...; fig s2d
| Chang J, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols B, et al. Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier. Cell Rep Med. 2022;3:100497 pubmed publisher |
- immunohistochemistry; African green monkey; 1:100; fig 1c
- western blot; African green monkey; 1:5000; loading ...; fig 4c
- western blot; rat; 1:5000; loading ...; fig 4c
| Watanabe D, Nakagawa S, Morofuji Y, Tóth A, Vastag M, Aruga J, et al. Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes. Pharmaceutics. 2021;13: pubmed publisher |
- immunohistochemistry - paraffin section; dogs; 1:200; loading ...; fig 2b
| Rozolen J, Teodoro T, Sobral R, Sueiro F, Laufer Amorim R, Elias F, et al. Investigation of Prognostic Value of Claudin-5, PSMA, and Ki67 Expression in Canine Splenic Hemangiosarcoma. Animals (Basel). 2021;11: pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 1d
| Gruber T, Pan C, Contreras R, Wiedemann T, Morgan D, Skowronski A, et al. Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metab. 2021;33:1155-1170.e10 pubmed publisher |
- immunohistochemistry; zebrafish ; 1:500; loading ...; fig 1d
| Parab S, Quick R, Matsuoka R. Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain. elife. 2021;10: pubmed publisher |
| Liu C, Yamazaki Y, Heckman M, Martens Y, Jia L, Yamazaki A, et al. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimers Dement. 2020;16:1372-1383 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 8e
| Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel M, et al. HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathol. 2020;140:183-208 pubmed publisher |
- immunohistochemistry; human; 1:200; loading ...; fig 3c
| Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed publisher |
- immunohistochemistry; mouse; fig 1d
| Yang Z, Huang C, Wu Y, Chen B, Zhang W, Zhang J. Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation. Front Physiol. 2019;10:2 pubmed publisher |
- immunocytochemistry; human; fig 1h
| Wevers N, Kasi D, Gray T, Wilschut K, Smith B, van Vught R, et al. A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport. Fluids Barriers CNS. 2018;15:23 pubmed publisher |
- western blot; rat; fig 2a
| Rempe R, Hartz A, Soldner E, Sokola B, Alluri S, Abner E, et al. Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy. J Neurosci. 2018;38:4301-4315 pubmed publisher |
- western blot; mouse; 1:800; loading ...; fig 4g, 4i
| Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi J, Gangarossa G, et al. Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity. Neuroscience. 2018;370:130-138 pubmed publisher |
- western blot; mouse; 1:5000; loading ...; fig 3b
| Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5b
| Swanson P, Hart G, Russo M, Nayak D, Yazew T, Pena M, et al. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 2016;12:e1006022 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 7d
| Chehaibi K, le Maire L, Bradoni S, Escolà J, Blanco Vaca F, Slimane M. Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury. Transl Res. 2017;182:27-48 pubmed publisher |
- western blot; mouse; 1:500; loading ...
| Gautam J, Zhang X, Yao Y. The role of pericytic laminin in blood brain barrier integrity maintenance. Sci Rep. 2016;6:36450 pubmed publisher |
- western blot; rat; 1:500; loading ...; fig 6c
| Huang L, Cao W, Deng Y, Zhu G, Han Y, Zeng H. Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes. BMC Neurosci. 2016;17:64 pubmed |
- immunocytochemistry; rat; 1:100; loading ...; fig 3c
| Mendonça M, Soares E, de Jesus M, Ceragioli H, Batista Ã, Nyúl Tóth Ã, et al. PEGylation of Reduced Graphene Oxide Induces Toxicity in Cells of the Blood-Brain Barrier: An in Vitro and in Vivo Study. Mol Pharm. 2016;13:3913-3924 pubmed |
- immunocytochemistry; mouse; fig s1
| Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T. Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation. J Cereb Blood Flow Metab. 2017;37:2471-2484 pubmed publisher |
- immunohistochemistry - paraffin section; dogs; 1:200; loading ...; fig 2d
- western blot; dogs; 1:1000; loading ...; fig 1h
| Ahn C, Shin D, Lee D, Kang S, Seok J, Kang H, et al. Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep. 2016;14:3697-703 pubmed publisher |
- immunocytochemistry; human; 1:50; fig 2e
| Clark P, Al Ahmad A, Qian T, Zhang R, Wilson H, Weichert J, et al. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016;13:3341-9 pubmed publisher |
- immunohistochemistry; rat; 1:50; loading ...; fig 1d
- western blot; rat; 1:500; loading ...; fig 3b
| Ge X, Huang S, Gao H, Han Z, Chen F, Zhang S, et al. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain Res. 2016;1650:31-40 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; tbl 2
| Peckova K, Michal M, Hadravsky L, Suster S, Damjanov I, Miesbauerova M, et al. Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. Histopathology. 2016;69:762-774 pubmed publisher |
- immunohistochemistry - frozen section; mouse; fig 1
| Nishida Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, et al. Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J Biol Chem. 2016;291:10490-500 pubmed publisher |
- western blot; mouse; 1:500; fig 5
| Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, et al. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol. 2016;131:753-73 pubmed publisher |
- immunocytochemistry; human; fig 4
| Sreekanthreddy P, Gromnicova R, Davies H, Phillips J, Romero I, Male D. A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions. F1000Res. 2015;4:1279 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 3c
- western blot; human; loading ...; fig 3a
| Schossleitner K, Rauscher S, Gröger M, Friedl H, Finsterwalder R, Habertheuer A, et al. Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2016;36:647-54 pubmed publisher |
- immunohistochemistry; tiger salamander; 1:500; fig 1
| Rodrigo Albors A, Tazaki A, Rost F, Nowoshilow S, Chara O, Tanaka E. Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. elife. 2015;4:e10230 pubmed publisher |
- immunocytochemistry; human; 1:50; fig 2
| Stebbins M, Wilson H, Canfield S, Qian T, Palecek S, Shusta E. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods. 2016;101:93-102 pubmed publisher |
- immunohistochemistry; mouse; 1:50
| Brkic M, Balusu S, Van Wonterghem E, Gorlé N, Benilova I, Kremer A, et al. Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. J Neurosci. 2015;35:12766-78 pubmed publisher |
- immunocytochemistry; human; 1:50
- western blot; human; 1:250
| Zhao Y, Zhao L, Wang P, Miao Y, Liu Y, Wang Z, et al. Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin. J Neurosci Res. 2015;93:1891-902 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:50; fig 1
| Zehendner C, Sebastiani A, Hugonnet A, Bischoff F, Luhmann H, Thal S. Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex. Sci Rep. 2015;5:13497 pubmed publisher |
- western blot; human; 0.5 ug/ml
| Smith N, Hinley J, Varley C, Eardley I, Trejdosiewicz L, Southgate J. The human urothelial tight junction: claudin 3 and the ZO-1α+ switch. Bladder (San Franc). 2015;2:e9 pubmed |
| Tan F, Fu W, Cheng N, Meng D, Gu Y. Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion. Exp Ther Med. 2015;9:1757-1762 pubmed |
- immunohistochemistry - frozen section; mouse; 1:500
| Shah K, Boreddy P, Abbruscato T. Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice. Fluids Barriers CNS. 2015;12:10 pubmed publisher |
| Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed publisher |
- western blot; human; 1:300-500
| Sajja R, Green K, Cucullo L. Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro. PLoS ONE. 2015;10:e0122358 pubmed publisher |
- western blot; mouse; 1:1000
| Muramatsu R, Kuroda M, Matoba K, Lin H, Takahashi C, Koyama Y, et al. Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J Biol Chem. 2015;290:11515-25 pubmed publisher |
- immunohistochemistry; rat; 2 ug/ml
| Ghersi Egea J, Babikian A, Blondel S, Strazielle N. Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation. Fluids Barriers CNS. 2015;12:8 pubmed publisher |
- immunohistochemistry; black-tailed prairie dog; 1:100
| Meekins J, Eshar D, Rankin A, Henningson J. Clinical and histologic description of ocular anatomy in captive black-tailed prairie dogs (Cynomys ludovicianus). Vet Ophthalmol. 2016;19:110-6 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50
| Nissi R, Talvensaari Mattila A, Kuvaja P, Pääkkö P, Soini Y, Santala M. Claudin-5 is associated with elevated TATI and CA125 levels in mucinous ovarian borderline tumors. Anticancer Res. 2015;35:973-6 pubmed |
- immunohistochemistry; human; 1:150
| Pienaar I, Lee C, Elson J, McGuinness L, Gentleman S, Kalaria R, et al. Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiol Dis. 2015;74:392-405 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 4a
| Scotti L, Abramovich D, Pascuali N, Durand L, Irusta G, de Zúñiga I, et al. Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS). Reprod Fertil Dev. 2016;28:690-9 pubmed publisher |
- immunohistochemistry; human; 1:50
- western blot; human; 1:125
| Swager S, DelfÃn D, Rastogi N, Wang H, Canan B, Fedorov V, et al. Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1. Cardiovasc Pathol. 2015;24:160-167 pubmed publisher |
- immunohistochemistry; mouse; 1:300; fig 4
- western blot; mouse; 1:1000
| Braniste V, Al Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6:263ra158 pubmed publisher |
| Casselbrant A, Elias E, Fändriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed publisher |
- western blot; rat; 1:2000; fig 6
| Scotti L, Abramovich D, Pascuali N, Irusta G, Meresman G, Tesone M, et al. Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome. J Steroid Biochem Mol Biol. 2014;144 Pt B:392-401 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1e
| Virman J, Soini Y, Kujala P, Luukkaala T, Salminen T, Sunela K, et al. Claudins as prognostic factors for renal cell cancer. Anticancer Res. 2014;34:4181-7 pubmed |
| Yang N, Liu Y, Pan C, Sun K, Wei X, Mao X, et al. Pretreatment with andrographolide pills(®) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Microcirculation. 2014;21:703-16 pubmed publisher |
- immunocytochemistry; human
| Takeshita Y, Obermeier B, Cotleur A, Sano Y, Kanda T, Ransohoff R. An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture. J Neurosci Methods. 2014;232:165-72 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:400
| Ben Zvi A, Lacoste B, Kur E, Andreone B, Mayshar Y, Yan H, et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014;509:507-11 pubmed publisher |
- immunocytochemistry; human; 1:150
- western blot; human; 1:350
| Sajja R, Prasad S, Cucullo L. Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line. Fluids Barriers CNS. 2014;11:8 pubmed publisher |
- immunocytochemistry; mouse; 1:50
| Zehendner C, White R, Hedrich J, Luhmann H. A neurovascular blood-brain barrier in vitro model. Methods Mol Biol. 2014;1135:403-13 pubmed publisher |
- immunocytochemistry; mouse; 1:50; tbl 1
| Zehendner C, Librizzi L, Hedrich J, Bauer N, Angamo E, de Curtis M, et al. Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption. PLoS ONE. 2013;8:e82823 pubmed publisher |
- immunohistochemistry; mouse; 1:50; fig 1
| Zehendner C, Wedler H, Luhmann H. A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex. PLoS ONE. 2013;8:e81637 pubmed publisher |
- western blot; rat; 1:1000
| Hawkins K, Demars K, Singh J, Yang C, Cho H, Frankowski J, et al. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke. J Neurochem. 2014;129:130-42 pubmed publisher |
- immunocytochemistry; rat
- western blot; rat; 1:500
| Watson P, Paterson J, Thom G, Ginman U, Lundquist S, Webster C. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier. BMC Neurosci. 2013;14:59 pubmed publisher |
- western blot; domestic sheep; 1:5000; fig 2
| Szczepkowska A, Lagaraine C, Robert V, Dufourny L, Thiery J, Skipor J. Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods. Neurotoxicol Teratol. 2013;37:63-7 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1b
| Nordfors K, Haapasalo J, Sallinen P, Haapasalo H, Soini Y. Expression of claudins relates to tumour aggressivity, location and recurrence in ependymomas. Histol Histopathol. 2013;28:1137-46 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 4
| Strazielle N, Ghersi Egea J. Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. Mol Pharm. 2013;10:1473-91 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 1
| Lappi Blanco E, Lehtonen S, Sormunen R, Merikallio H, Soini Y, Kaarteenaho R. Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis. Hum Pathol. 2013;44:895-907 pubmed publisher |
- immunocytochemistry; human; 1:200
- western blot; human; 1:1000
| Krouwer V, Hekking L, Langelaar Makkinje M, Regan Klapisz E, Post J. Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability. Vasc Cell. 2012;4:12 pubmed publisher |
- immunohistochemistry - frozen section; rat; 1.25 ug/ml
- western blot; rat; 1 ug/ml; fig 2, 3
- immunohistochemistry - paraffin section; human; 2.5 ug/ml; fig 2, 3
| Kratzer I, Vasiljevic A, Rey C, Fevre Montange M, Saunders N, Strazielle N, et al. Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier. Histochem Cell Biol. 2012;138:861-79 pubmed publisher |
- western blot; rat; 1:500; fig 2
| Northrop N, Yamamoto B. Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier. J Neuroimmune Pharmacol. 2012;7:951-68 pubmed publisher |
- immunocytochemistry; mouse; fig 4
| Johnson H, Chen Y, Jin F, Hanson L, Gamez J, Pirko I, et al. CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support. J Immunol. 2012;189:1937-45 pubmed publisher |
- immunohistochemistry - frozen section; rat; 1:50; fig 2
- western blot; rat; 1:250; fig 2
| Raposo C, Odorissi P, Oliveira A, Aoyama H, Ferreira C, Verinaud L, et al. Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier. Neurochem Res. 2012;37:1967-81 pubmed publisher |
- western blot; mouse; 1:100; fig 2
| Delfin D, Xu Y, Schill K, Mays T, Canan B, Zang K, et al. Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model. Mol Ther. 2012;20:1378-83 pubmed publisher |
- immunohistochemistry; rat; fig 6
| Géraud C, Evdokimov K, Straub B, Peitsch W, Demory A, Dörflinger Y, et al. Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PLoS ONE. 2012;7:e34206 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100
- western blot; human; 1:1000
| Ghule V, Gray C, Galimberti A, Anumba D. Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins. J Transl Med. 2012;10:40 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 3
| Riski M, Santala M, Soini Y, Talvensaari Mattila A. Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma. Tumour Biol. 2012;33:537-42 pubmed publisher |
- immunocytochemistry; human; fig 1
| Lecuyer H, Nassif X, Coureuil M. Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells. Infect Immun. 2012;80:175-86 pubmed publisher |
- immunohistochemistry - frozen section; mouse; tbl 1
| Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren Wiemers N, et al. Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 2011;122:601-14 pubmed publisher |
- immunohistochemistry; human; fig 1
| Miettinen M, Sarlomo Rikala M, Wang Z. Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas. Am J Surg Pathol. 2011;35:1848-56 pubmed publisher |
- immunocytochemistry; human; 1:150; fig 1
- western blot; human; 1:500; fig 2
| Mandel I, Paperna T, Glass Marmor L, Volkowich A, Badarny S, Schwartz I, et al. Tight junction proteins expression and modulation in immune cells and multiple sclerosis. J Cell Mol Med. 2012;16:765-75 pubmed publisher |
- western blot; domestic sheep; 1:5000; fig 1
| Lagaraine C, Skipor J, Szczepkowska A, Dufourny L, Thiery J. Tight junction proteins vary in the choroid plexus of ewes according to photoperiod. Brain Res. 2011;1393:44-51 pubmed publisher |
- immunohistochemistry; pigs ; 1:200; fig 1
| Zehendner C, Librizzi L, de Curtis M, Kuhlmann C, Luhmann H. Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage. PLoS ONE. 2011;6:e16760 pubmed publisher |
- western blot; pigs ; fig 1
| Butt O, Buehler P, D Agnillo F. Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol. 2011;178:1316-28 pubmed publisher |
- immunohistochemistry; mouse; 10 ug/ml; fig 2
- western blot; mouse; 0.5 ug/ml; fig 3
| Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, et al. Novel expression of claudin-5 in glomerular podocytes. Cell Tissue Res. 2011;343:637-48 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:45; fig 2
| Manias J, Kapadia A, Nag S. Detection of multiple proteins in intracerebral vessels by confocal microscopy. Methods Mol Biol. 2011;686:177-92 pubmed publisher |
- western blot; human; fig s4
| Su S, Maxwell S, Bayless K. Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. J Biol Chem. 2010;285:40624-34 pubmed publisher |
- immunohistochemistry; human; fig 4
| Powner M, Gillies M, Tretiach M, Scott A, Guymer R, Hageman G, et al. Perifoveal müller cell depletion in a case of macular telangiectasia type 2. Ophthalmology. 2010;117:2407-16 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; tbl 1
| Turunen M, Talvensaari Mattila A, Soini Y, Santala M. Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma. Anticancer Res. 2009;29:5185-9 pubmed |
- immunohistochemistry; rat; 1:100; fig 8
| Shen W, Li S, Chung S, Gillies M. Retinal vascular changes after glial disruption in rats. J Neurosci Res. 2010;88:1485-99 pubmed publisher |
- immunohistochemistry; mouse; 1:100; fig 2
- western blot; mouse; 1:250-1:500; fig 1
| Bauer A, Bürgers H, Rabie T, Marti H. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J Cereb Blood Flow Metab. 2010;30:837-48 pubmed publisher |
| HERRERA J, Haywood Watson R, Grill R. Acute and chronic deficits in the urinary bladder after spinal contusion injury in the adult rat. J Neurotrauma. 2010;27:423-31 pubmed publisher |
- western blot; domestic sheep; 1:5000; fig 2c
| Sadowska G, Malaeb S, Stonestreet B. Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep. Am J Physiol Heart Circ Physiol. 2010;298:H179-88 pubmed publisher |
- immunohistochemistry; mouse; 1:100; fig 4
| Yemisci M, Gursoy Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med. 2009;15:1031-7 pubmed publisher |
- immunocytochemistry; human; fig 4
- western blot; human; fig 4
| Regan Klapisz E, Krouwer V, Langelaar Makkinje M, Nallan L, Gelb M, Gerritsen H, et al. Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins. Mol Biol Cell. 2009;20:4225-34 pubmed publisher |
- western blot; rat; 1:1000
| Waldow T, Witt W, Janke A, Ulmer A, Buzin A, Matschke K. Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide. J Surg Res. 2009;157:30-42 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100; fig 1
| Alanne M, Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J Histochem Cytochem. 2009;57:523-9 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1e
| Kaarteenaho Wiik R, Soini Y. Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis. J Histochem Cytochem. 2009;57:187-95 pubmed publisher |
- immunocytochemistry; human; fig 3d
| Neuhaus W, Wirth M, Plattner V, Germann B, Gabor F, Noe C. Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media. Neurosci Lett. 2008;446:59-64 pubmed publisher |
- western blot; human; fig 2
| Su S, Mendoza E, Kwak H, Bayless K. Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing. Am J Physiol Cell Physiol. 2008;295:C1215-29 pubmed publisher |
- immunohistochemistry - frozen section; rat; 1:50
| Norsted E, Gömüç B, Meister B. Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus. J Chem Neuroanat. 2008;36:107-21 pubmed publisher |
- immunohistochemistry - paraffin section; human; 20 ug/ml; tbl 1
| Reynolds G, Harris H, Jennings A, Hu K, Grove J, Lalor P, et al. Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology. 2008;47:418-27 pubmed |
- immunoprecipitation; human; fig 7
| Akat K, Bleck C, Lee Y, Haselmann Weiss U, Kartenbeck J. Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52. Cell Tissue Res. 2008;331:401-12 pubmed |
- immunocytochemistry; rat; 1:100; fig 1
- western blot; rat; 1:500; fig 1
| McCaffrey G, Staatz W, Quigley C, Nametz N, Seelbach M, Campos C, et al. Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo. J Neurochem. 2007;103:2540-55 pubmed publisher |
- immunohistochemistry - frozen section; rat
| Uehara K, Uehara A. Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells. Histochem Cell Biol. 2008;129:95-103 pubmed |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 2e
| Takala H, Saarnio J, Wiik H, Soini Y. Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associated with metastatic behavior. APMIS. 2007;115:838-47 pubmed |
- immunohistochemistry; human; fig 1
| Paschoud S, Bongiovanni M, Pache J, Citi S. Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol. 2007;20:947-54 pubmed |
- western blot; rat; 1:1000; fig 3
| Morgan L, Shah B, Rivers L, Barden L, Groom A, Chung R, et al. Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis. Neuroscience. 2007;147:664-73 pubmed |
- immunohistochemistry - frozen section; human; fig 1
| Peltonen S, Riehokainen J, Pummi K, Peltonen J. Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis. Br J Dermatol. 2007;156:466-72 pubmed |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1d
| Bello I, Soini Y, Slootweg P, Salo T. Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med. 2007;36:48-54 pubmed |
- immunohistochemistry - paraffin section; human; 1:50
| Soini Y, Kinnula V, Kahlos K, Paakko P. Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura. J Clin Pathol. 2006;59:250-4 pubmed |
- immunohistochemistry - frozen section; human
| Pummi K, Aho H, Laato M, Peltonen J, Peltonen S. Tight junction proteins and perineurial cells in neurofibromas. J Histochem Cytochem. 2006;54:53-61 pubmed |
- immunohistochemistry; human; tbl 1
| Brandner J, McIntyre M, Kief S, Wladykowski E, Moll I. Expression and localization of tight junction-associated proteins in human hair follicles. Arch Dermatol Res. 2003;295:211-21 pubmed |
- western blot; human; fig 3
| Wang F, Daugherty B, Keise L, Wei Z, Foley J, Savani R, et al. Heterogeneity of claudin expression by alveolar epithelial cells. Am J Respir Cell Mol Biol. 2003;29:62-70 pubmed |
| Yamauchi H, Hitomi T, Takata A. Evaluation of arsenic metabolism and tight junction injury after exposure to arsenite and monomethylarsonous acid using a rat in vitro blood-Brain barrier model. PLoS ONE. 2023;18:e0295154 pubmed publisher |
| Est C, Murphy R. An in vitro model for vitamin A transport across the human blood-brain barrier. elife. 2023;12: pubmed publisher |
| Amato R, Melecchi A, Pucci L, Canovai A, Marracci S, Cammalleri M, et al. Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice. Cells. 2023;12: pubmed publisher |
| Nair A, Groenendijk L, Overdevest R, Fowke T, Annida R, Mocellin O, et al. Human BBB-on-a-chip reveals barrier disruption, endothelial inflammation, and T cell migration under neuroinflammatory conditions. Front Mol Neurosci. 2023;16:1250123 pubmed publisher |
| Bolden C, Skibber M, Olson S, Zamorano Rojas M, Milewicz S, Gill B, et al. Validation and characterization of a novel blood-brain barrier platform for investigating traumatic brain injury. Sci Rep. 2023;13:16150 pubmed publisher |
| Nicese M, Bijkerk R, van Zonneveld A, van den Berg B, Rotmans J. Sodium Butyrate as Key Regulator of Mitochondrial Function and Barrier Integrity of Human Glomerular Endothelial Cells. Int J Mol Sci. 2023;24: pubmed publisher |
| Matsumoto T, Matsumoto J, Matsushita Y, Arimura M, Aono K, Aoki M, et al. Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells. Int J Mol Sci. 2023;24: pubmed publisher |
| Yang J, Li Y, Bhalla A, Maienschein Cline M, Fukuchi K. A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells. PLoS ONE. 2023;18:e0288497 pubmed publisher |
| Byun D, Lee J, Yu J, Hyun Y. NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain. Immune Netw. 2023;23:e27 pubmed publisher |
| Hamada Y, Ogata S, Masuda T, Ito S, Ohtsuki S. Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries. Fluids Barriers CNS. 2023;20:50 pubmed publisher |
| Wang J, Rattner A, Nathans J. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution. elife. 2023;12: pubmed publisher |
| Foreman K, Shusta E, Palecek S. Defined Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial-Like Cells for Modeling the Blood-Brain Barrier. Methods Mol Biol. 2023;2683:113-133 pubmed publisher |
| Villalba N, Ma Y, Gahan S, Joly Amado A, Spence S, Yang X, et al. Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice. J Neuroinflammation. 2023;20:127 pubmed publisher |
| Liu Y, Liu X, Sun P, Li J, Nie M, Gong J, et al. rTMS treatment for abrogating intracerebral hemorrhage-induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage. Brain Behav. 2023;13:e3062 pubmed publisher |
| Mamana J, Humber G, Espinal E, Seo S, Vollmuth N, Sin J, et al. Coxsackievirus B3 infects and disrupts human induced-pluripotent stem cell derived brain-like endothelial cells. Front Cell Infect Microbiol. 2023;13:1171275 pubmed publisher |
| Lugano R, Vemuri K, Barbera S, Orlandini M, Dejana E, Claesson Welsh L, et al. CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin. FASEB J. 2023;37:e22894 pubmed publisher |
| Wang Y, Su L, Wang W, Zhao J, Wang Y, Li S, et al. Endothelial Arid1a deletion disrupts the balance among angiogenesis, neurogenesis and gliogenesis in the developing brain. Cell Prolif. 2023;56:e13447 pubmed publisher |
| Archie S, Sifat A, Zhang Y, Villalba H, Sharma S, Nozohouri S, et al. Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age. Fluids Barriers CNS. 2023;20:17 pubmed publisher |
| Zhang J, Zhang Y, McGrenaghan C, Kelly V, Xia Y, Sun J. Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2023;15:1371-1389 pubmed publisher |
| Li Y, Sun Z, Zhu H, Sun Y, Shteyman D, Markx S, et al. Inhibition of Abl Kinase by Imatinib Can Rescue the Compromised Barrier Function of 22q11.2DS Patient-iPSC-Derived Blood-Brain Barriers. Cells. 2023;12: pubmed publisher |
| Kim H, Noh M, Zhang H, Kim Y, Park S, Park J, et al. Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model. Fluids Barriers CNS. 2023;20:9 pubmed publisher |
| van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park J, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023;26:416-429 pubmed publisher |
| Luo Y, Yao F, Shi Y, Zhu Z, Xiao Z, You X, et al. Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells. Fluids Barriers CNS. 2023;20:1 pubmed publisher |
| Lu Y, Chen X, Liu X, Shi Y, Wei Z, Feng L, et al. Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction. Autophagy. 2023;:1-18 pubmed publisher |
| Hernandez S, Lim R, Onur T, Dane M, Smith R, Wang K, et al. An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells. Hum Mol Genet. 2023;32:1483-1496 pubmed publisher |
| Rodriguez Ortiz C, Thorwald M, Rodriguez R, Mejias Ortega M, Kieu Z, Maitra N, et al. Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats. Clin Exp Pharmacol Physiol. 2023;50:228-237 pubmed publisher |
| Liu N, Zhu Y, Yu K, Gu Z, Lv S, Chen Y, et al. Functional Blood-Brain Barrier Model with Tight Connected Minitissue by Liquid Substrates Culture. Adv Healthc Mater. 2023;12:e2201984 pubmed publisher |
| Henao Restrepo J, L xf3 pez Murillo C, Valderrama Carmona P, Orozco Santa N, Gomez J, Guti xe9 rrez Vargas J, et al. Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection. Brain Pathol. 2023;33:e13119 pubmed publisher |
| Brunner N, Stein L, Amasheh S. Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins. J Membr Biol. 2023;256:51-61 pubmed publisher |
| Li W, Mandeville E, Dur xe1 n Laforet V, Fukuda N, Yu Z, Zheng Y, et al. Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun. 2022;13:7812 pubmed publisher |
| Rajeev V, Fann D, Dinh Q, Kim H, De Silva T, Jo D, et al. Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment. Int J Biol Sci. 2022;18:6052-6067 pubmed publisher |
| Wang N, Wang M, Jeevaratnam S, Rosenberg C, Ikezu T, Shue F, et al. Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination. Mol Neurodegener. 2022;17:75 pubmed publisher |
| Xu L, Nirwane A, Xu T, Kang M, Devasani K, Yao Y. Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2. Cell Rep. 2022;41:111709 pubmed publisher |
| Xue Y, Wang X, Wan B, Wang D, Li M, Cheng K, et al. Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema. Cell Commun Signal. 2022;20:160 pubmed publisher |
| Qian X, Liu X, Chen G, Chen S, Tang H. Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer's disease. J Neuroinflammation. 2022;19:236 pubmed publisher |
| Palomino S, Levine A, Wahl J, Liktor Busa E, Streicher J, Largent Milnes T. Inhibition of HSP90 Preserves Blood-Brain Barrier Integrity after Cortical Spreading Depression. Pharmaceutics. 2022;14: pubmed publisher |
| Jhun H, Lee W, Park J, Hwang S, Park H. Transcriptomic Analysis of Testicular Gene Expression in a Dog Model of Experimentally Induced Cryptorchidism. Cells. 2022;11: pubmed publisher |
| Choi J, Park J, Jo C, Kim K, Koh Y. SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells. Biochem Biophys Res Commun. 2022;626:66-71 pubmed publisher |
| Hammash D, Mahfood M, Khoder G, Ahmed M, Tlili A, Hamoudi R, et al. miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells. Breast Cancer (Dove Med Press). 2022;14:187-198 pubmed publisher |
| Liu C, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, et al. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nat Neurosci. 2022;25:1020-1033 pubmed publisher |
| Nonoguchi H, Kouo T, Kortagere S, Hillman J, Boyle D, Mandyam C. Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats. Brain Sci. 2022;12: pubmed publisher |
| Wahl J, Vivek A, Palomino S, Almuslim M, Cottier K, Langlais P, et al. Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome. Pharmaceutics. 2022;14: pubmed publisher |
| Thinard R, Farkas A, Halasa M, Chevalier M, Brodaczewska K, Majewska A, et al. "Endothelial Antibody Factory" at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases. Pharmaceutics. 2022;14: pubmed publisher |
| Richards M, Nwadozi E, Pal S, Martinsson P, Kaakinen M, Gloger M, et al. Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner. elife. 2022;11: pubmed publisher |
| Zhao C, Zhou T, Zhao X, Pang Y, Li W, Fan B, et al. Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood-spinal cord barrier breakdown during acute spinal cord injury in rats. J Neuroinflammation. 2022;19:189 pubmed publisher |
| Navarrete C, Garc xed a Mart xed n A, Correa S xe1 ez A, Prados M, Fern xe1 ndez F, Pineda R, et al. A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury. J Neuroinflammation. 2022;19:177 pubmed publisher |
| Wang Q, Huang X, Su Y, Yin G, Wang S, Yu B, et al. Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease. Brain. 2022;145:4474-4488 pubmed publisher |
| Piantino M, Kang D, Furihata T, Nakatani N, Kitamura K, Shigemoto Mogami Y, et al. Development of a three-dimensional blood-brain barrier network with opening capillary structures for drug transport screening assays. Mater Today Bio. 2022;15:100324 pubmed publisher |
| Molins Guti xe9 rrez G, Martorell J, Salazar Martín A, Balcells M. A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress. Methods Mol Biol. 2022;2492:175-190 pubmed publisher |
| Meena A, Shukla P, Bell B, Giorgianni F, Caires R, Fernández Peña C, et al. TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response. Cell Rep. 2022;39:110937 pubmed publisher |
| Kiani Shabestari S, Morabito S, Danhash E, McQuade A, Sanchez J, Miyoshi E, et al. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Rep. 2022;39:110961 pubmed publisher |
| Zhang Q, Liu C, Shi R, Zhou S, Shan H, Deng L, et al. Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke. Aging Dis. 2022;13:943-959 pubmed publisher |
| Yang J, Betterton R, Williams E, Stanton J, Reddell E, Ogbonnaya C, et al. High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats. Pharmaceutics. 2022;14: pubmed publisher |
| Mishra A, Dupla xe0 C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilh xe3 o N, et al. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain. 2022;145:1992-2007 pubmed publisher |
| Wang W, Su L, Wang Y, Li C, Ji F, Jiao J. Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch During Brain Development. Adv Sci (Weinh). 2022;9:e2105208 pubmed publisher |
| van Leeuwen E, Hampton M, Smyth L. Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells. Antioxidants (Basel). 2022;11: pubmed publisher |
| Garvin J, Semenikhina M, Liu Q, Rarick K, Isaeva E, Levchenko V, et al. Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2022;322:R571-R580 pubmed publisher |
| Piantino M, Louis F, Shigemoto Mogami Y, Kitamura K, Sato K, Yamaguchi T, et al. Brain microvascular endothelial cells derived from human induced pluripotent stem cells as in vitro model for assessing blood-brain barrier transferrin receptor-mediated transcytosis. Mater Today Bio. 2022;14:100232 pubmed publisher |
| Xu J, Xu L, Sui P, Chen J, Moya E, Hume P, et al. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022;57:839-853.e6 pubmed publisher |
| Khan A, Ni W, Baltazar T, Lopez Giraldez F, Pober J, Pierce R. ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak. FASEB J. 2022;36:e22254 pubmed publisher |
| Boyé K, Geraldo L, Furtado J, Pibouin Fragner L, Poulet M, Kim D, et al. Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022;13:1169 pubmed publisher |
| Lin P, Tan R, Yu P, Li Y, Mo Y, Li W, et al. Autophagic degradation of claudin-5 mediated by its binding to a Clostridium perfringens enterotoxin fragment modulates endothelial barrier permeability. FEBS Lett. 2022;596:924-937 pubmed publisher |
| Deng L, Qi L, Suo Q, Wu S, Mamtilahun M, Shi R, et al. Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice. Neural Regen Res. 2022;17:2058-2063 pubmed publisher |
| Williams L, Fujimoto T, Weaver R, Logsdon A, Evitts K, Young J, et al. Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu. Fluids Barriers CNS. 2022;19:10 pubmed publisher |
| Miedema A, Gerrits E, Brouwer N, Jiang Q, Kracht L, Meijer M, et al. Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter. Acta Neuropathol Commun. 2022;10:8 pubmed publisher |
| Hansen L, Lohfink N, Vutukuri R, Kestner R, Trautmann S, Hecht M, et al. Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype. J Neurosci. 2022;42:1908-1929 pubmed publisher |
| Nagano H, Ito S, Masuda T, Ohtsuki S. Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood-Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells. Pharm Res. 2022;39:1561-1574 pubmed publisher |
| Yang Z, Huang C, Wen X, Liu W, Huang X, Li Y, et al. Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. Mol Ther. 2022;30:1275-1287 pubmed publisher |
| Yu R, Kim N, Li Y, Jeong J, Park S, Zhou B, et al. Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. Transl Stroke Res. 2022;13:142-159 pubmed publisher |
| Yanckello L, Hoffman J, Chang Y, Lin P, Nehra G, Chlipala G, et al. Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis. Nutr Neurosci. 2022;25:1669-1679 pubmed publisher |
| Ye Y, Li Q, Pan C, Yan L, Sun K, Wang X, et al. QiShenYiQi Inhibits Tissue Plasminogen Activator-Induced Brain Edema and Hemorrhage after Ischemic Stroke in Mice. Front Pharmacol. 2021;12:759027 pubmed publisher |
| Robey R, Robinson A, Ali Rahmani F, Huff L, Lusvarghi S, Vahedi S, et al. Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter. Sci Rep. 2021;11:24150 pubmed publisher |
| Gastfriend B, Nishihara H, Canfield S, Foreman K, Engelhardt B, Palecek S, et al. Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells. elife. 2021;10: pubmed publisher |
| Bony B, Tarudji A, Miller H, Gowrikumar S, Roy S, Curtis E, et al. Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood-Brain Barrier. ACS Nano. 2021;15:18520-18531 pubmed publisher |
| Salman M, Ismael S, Li L, Ahmed H, Puchowicz M, Ishrat T. Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy. Pharmaceuticals (Basel). 2021;14: pubmed publisher |
| Pediaditakis I, Kodella K, Manatakis D, Le C, Hinojosa C, Tien Street W, et al. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption. Nat Commun. 2021;12:5907 pubmed publisher |
| Wang C, Dong J, Sun J, Huang S, Wu F, Zhang X, et al. Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke. Mol Ther Nucleic Acids. 2021;26:148-160 pubmed publisher |
| Zhang L, Zhou L, Bao L, Liu J, Zhu H, Lv Q, et al. SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration. Signal Transduct Target Ther. 2021;6:337 pubmed publisher |
| Kozma M, M xe9 sz xe1 ros x, Ny xfa l T xf3 th x, Moln xe1 r K, Costea L, Hern xe1 di Z, et al. Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals. Int J Mol Sci. 2021;22: pubmed publisher |
| Sivandzade F, Alqahtani F, Cucullo L. Impact of chronic smoking on traumatic brain microvascular injury: An in vitro study. J Cell Mol Med. 2021;25:7122-7134 pubmed publisher |
| Nishihara H, Gastfriend B, Kasap P, Palecek S, Shusta E, Engelhardt B. Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions. STAR Protoc. 2021;2:100563 pubmed publisher |
| Ivashkin V, Poluektov Y, Kogan E, Shifrin O, Sheptulin A, Kovaleva A, et al. Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome. PLoS ONE. 2021;16:e0252930 pubmed publisher |
| Wang R, Song W, Xie C, Zhong W, Xu H, Zhou Q, et al. Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages. J Inflamm Res. 2021;14:1973-1989 pubmed publisher |
| Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G. Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep. 2021;35:109168 pubmed publisher |
| Herrera M, Molina P, Souza Smith F. Ethanol-induced lymphatic endothelial cell permeability via MAP-kinase regulation. Am J Physiol Cell Physiol. 2021;321:C104-C116 pubmed publisher |
| Dong X, Lei Y, Yu Z, Wang T, Liu Y, Han G, et al. Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis. Theranostics. 2021;11:5107-5126 pubmed publisher |
| Ismael S, Nasoohi S, Yoo A, Mirzahosseini G, Ahmed H, Ishrat T. Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome. Mol Neurobiol. 2021;58:3792-3804 pubmed publisher |
| González Molina L, Villar Vesga J, Henao Restrepo J, Villegas A, Lopera F, Cardona Gómez G, et al. Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components. Front Aging Neurosci. 2021;13:593927 pubmed publisher |
| Heyburn L, Abutarboush R, Goodrich S, Urioste R, Batuure A, Wheel J, et al. Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model. Front Cell Neurosci. 2021;15:636707 pubmed publisher |
| Nguyen V, Chavali M, Larpthaveesarp A, Kodali S, Gonzalez G, Franklin R, et al. Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke. Pediatr Res. 2021;90:1161-1170 pubmed publisher |
| Shin H, Jeong E, Lee J, An H, Jang H, Ahn Y, et al. Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death. Antioxidants (Basel). 2021;10: pubmed publisher |
| Tang L, Zhang C, Yang Q, Xie H, Liu D, Tian H, et al. Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy. J Cell Physiol. 2021;236:5848-5864 pubmed publisher |
| Hollier P, Chapouly C, Diop A, Guimbal S, Cornuault L, Gadeau A, et al. Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability. Cardiovasc Res. 2021;117:2489-2501 pubmed publisher |
| Bennett M, Chin A, Lee H, Morales Cestero E, Strazielle N, Ghersi Egea J, et al. Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood-Brain Barrier after Traumatic Brain Injury. J Neurotrauma. 2021;38:385-398 pubmed publisher |
| Ogata S, Ito S, Masuda T, Ohtsuki S. Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis. J Cereb Blood Flow Metab. 2021;41:1026-1038 pubmed publisher |
| Yu Z, Zeng J, Wang J, Cui Y, Song X, Zhang Y, et al. Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. Cardiovasc Res. 2021;117:533-546 pubmed publisher |
| Jinnai M, Koning G, Singh Mallah G, Jonsdotter A, Leverin A, Svedin P, et al. A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups. Front Cell Neurosci. 2020;14:535320 pubmed publisher |
| Villar Vesga J, Henao Restrepo J, Voshart D, Aguillon D, Villegas A, Castaño D, et al. Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer's Disease Leads to Neuroglial and Endothelial Cell Degeneration. Front Aging Neurosci. 2020;12:587989 pubmed publisher |
| Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, et al. Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells. Cells. 2020;9: pubmed publisher |
| Zhang S, Gong P, Zhang J, Mao X, Zhao Y, Wang H, et al. Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes. Front Neurosci. 2020;14:582324 pubmed publisher |
| Salman M, Marsh G, Kusters I, Delince M, Di Caprio G, Upadhyayula S, et al. Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging. Front Bioeng Biotechnol. 2020;8:573775 pubmed publisher |
| Vázquez Rosa E, Shin M, Dhar M, Chaubey K, Cintrón Pérez C, Tang X, et al. P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition. Proc Natl Acad Sci U S A. 2020;117:27667-27675 pubmed publisher |
| Chavali M, Ulloa Navas M, Pérez Borreda P, Garcia Verdugo J, McQuillen P, Huang E, et al. Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury. Neuron. 2020;108:1130-1145.e5 pubmed publisher |
| Chaves C, Do T, Cegarra C, Roudières V, Tolou S, Thill G, et al. Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model. Pharmaceutics. 2020;12: pubmed publisher |
| Zhang H, Liu J, Liu Y, Su C, Fan G, Lu W, et al. Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4. Exp Ther Med. 2020;20:71 pubmed publisher |
| Villalba N, Baby S, Cha B, Yuan S. Site-specific opening of the blood-brain barrier by extracellular histones. J Neuroinflammation. 2020;17:281 pubmed publisher |
| Cobo Calvo A, Ruiz A, Richard C, Blondel S, Cavagna S, Strazielle N, et al. Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability. PLoS ONE. 2020;15:e0238301 pubmed publisher |
| Brunner N, Stein L, Cornelius V, Knittel R, Fallier Becker P, Amasheh S. Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction. Front Physiol. 2020;11:857 pubmed publisher |
| Bartosova M, Herzog R, Ridinger D, Lévai E, Jenei H, Zhang C, et al. Alanyl-Glutamine Restores Tight Junction Organization after Disruption by a Conventional Peritoneal Dialysis Fluid. Biomolecules. 2020;10: pubmed publisher |
| Lefevere E, Salinas Navarro M, Andries L, Noterdaeme L, Etienne I, Van Wonterghem E, et al. Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury. Glia. 2020;68:2643-2660 pubmed publisher |
| Tang J, Kang Y, Huang L, Wu L, Peng Y. TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin β 1 complex and regulating downstream FAK/RhoA signaling. Acta Pharm Sin B. 2020;10:987-1003 pubmed publisher |
| D Agnillo F, Zhang X, Williams M. Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis. Am J Pathol. 2020;190:2095-2110 pubmed publisher |
| Wang Z, Zheng Y, Wang F, Zhong J, Zhao T, Xie Q, et al. Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier. Sci Adv. 2020;6:eaay8627 pubmed publisher |
| Ittner C, Burek M, Störk S, Nagai M, Förster C. Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro. Front Cardiovasc Med. 2020;7:73 pubmed publisher |
| Lu J, Lu L, Yu Y, Baranowski J, Claud E. Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice. Sci Rep. 2020;10:8178 pubmed publisher |
| Chen C, Wu M, Ho Y, Gung P, Tsai M, Orekhov A, et al. Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration. Int J Mol Sci. 2020;21: pubmed publisher |
| Rom S, Heldt N, Gajghate S, Seliga A, Reichenbach N, Persidsky Y. Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles. Sci Rep. 2020;10:7274 pubmed publisher |
| Shen S, Yang C, Liu X, Zheng J, Liu Y, Liu L, et al. RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway. Mol Ther Oncolytics. 2020;17:138-152 pubmed publisher |
| Curtaz C, Schmitt C, Herbert S, Feldheim J, Schlegel N, Gosselet F, et al. Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model. Fluids Barriers CNS. 2020;17:31 pubmed publisher |
| Ma F, Sun P, Zhang X, HAMBLIN M, Yin K. Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke. Sci Signal. 2020;13: pubmed publisher |
| Zhang X, Wang L, Han Z, Dong J, Pang D, Fu Y, et al. KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke. J Neuroinflammation. 2020;17:107 pubmed publisher |
| Gautam J, Xu L, Nirwane A, Nguyen B, Yao Y. Loss of mural cell-derived laminin aggravates hemorrhagic brain injury. J Neuroinflammation. 2020;17:103 pubmed publisher |
| Aoki H, Yamashita M, Hashita T, Iwao T, Matsunaga T. Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity. Fluids Barriers CNS. 2020;17:25 pubmed publisher |
| Süß P, Hoffmann A, Rothe T, Ouyang Z, Baum W, Staszewski O, et al. Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep. 2020;30:4082-4095.e6 pubmed publisher |
| Hu H, Hone E, Provencher E, Sprowls S, Farooqi I, Corbin D, et al. MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes. Sci Rep. 2020;10:3233 pubmed publisher |
| Semina E, Rubina K, Shmakova A, Rysenkova K, Klimovich P, Aleksanrushkina N, et al. Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma. J Cell Physiol. 2020;235:6268-6286 pubmed publisher |
| Huang Y, Wang C, Tian X, Mao Y, Hou B, Sun Y, et al. Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction. Inflammation. 2020;43:568-578 pubmed publisher |
| Wu J, He J, Tian X, Luo Y, Zhong J, Zhang H, et al. microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury. J Neurochem. 2020;153:710-726 pubmed publisher |
| Sereno M, Hask xf3 J, Moln xe1 r K, Medina S, Reisz Z, Malh xf3 R, et al. Downregulation of circulating miR 802-5p and miR 194-5p and upregulation of brain MEF2C along breast cancer brain metastasization. Mol Oncol. 2020;14:520-538 pubmed publisher |
| Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, et al. Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun. 2019;10:5816 pubmed publisher |
| Rivera J, Isidro R, Loucil Alicea R, Cruz M, Appleyard C, Isidro A, et al. Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood-brain-barrier permeability. PLoS ONE. 2019;14:e0225760 pubmed publisher |
| Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, et al. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019;25:754-767.e9 pubmed publisher |
| Ohshima M, Kamei S, Fushimi H, Mima S, Yamada T, Yamamoto T. Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Biores Open Access. 2019;8:200-209 pubmed publisher |
| Franke W, Domke L, D xf6 rflinger Y, Zimbelmann R. The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature. Cell Tissue Res. 2020;379:75-92 pubmed publisher |
| Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann Y, Kanekiyo T, et al. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arterioscler Thromb Vasc Biol. 2020;40:128-144 pubmed publisher |
| Bernatz S, Ilina E, Devraj K, Harter P, Mueller K, Kleber S, et al. Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. J Exp Clin Cancer Res. 2019;38:434 pubmed publisher |
| SPANGENBERG E, Severson P, Hohsfield L, Crapser J, Zhang J, Burton E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019;10:3758 pubmed publisher |
| Schuhmann M, Stoll G, Papp L, Bohr A, Volkmann J, Fluri F. Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats. Int J Mol Sci. 2019;20: pubmed publisher |
| Haskó J, Fazakas C, Molnár K, Mészáros A, Patai R, Szabo G, et al. Response of the neurovascular unit to brain metastatic breast cancer cells. Acta Neuropathol Commun. 2019;7:133 pubmed publisher |
| Durán Laforet V, Fernández López D, García Culebras A, González Hijón J, Moraga A, Palma Tortosa S, et al. Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke. Front Neurosci. 2019;13:767 pubmed publisher |
| Katt M, Mayo L, Ellis S, Mahairaki V, Rothstein J, Cheng L, et al. The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids Barriers CNS. 2019;16:20 pubmed publisher |
| Vatine G, Barrile R, Workman M, Sances S, Barriga B, Rahnama M, et al. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Cell Stem Cell. 2019;24:995-1005.e6 pubmed publisher |
| Ouyang X, Dong C, Ubogu E. In situ molecular characterization of endoneurial microvessels that form the blood-nerve barrier in normal human adult peripheral nerves. J Peripher Nerv Syst. 2019;24:195-206 pubmed publisher |
| Ye Z, Xing H, Wang B, Liu M, Lv P. DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins. Chin Med J (Engl). 2019;132:1344-1353 pubmed publisher |
| Nirwane A, Johnson J, Nguyen B, Miner J, Yao Y. Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke. Acta Neuropathol Commun. 2019;7:23 pubmed publisher |
| Korecki A, Hickmott J, Lam S, Dreolini L, Mathelier A, Baker O, et al. Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele. Genetics. 2019;211:1155-1177 pubmed publisher |
| Nierwińska K, Nowacka Chmielewska M, Bernacki J, Jagsz S, Chalimoniuk M, Langfort J, et al. The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats. PLoS ONE. 2019;14:e0211818 pubmed publisher |
| Han X, Li Q, Lan X, El Mufti L, Ren H, Wang J. Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity. Mol Neurobiol. 2019;: pubmed publisher |
| Tan C, Lu N, Wang C, Chen D, Sun N, Lyu H, et al. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4. Neuron. 2019;101:920-937.e13 pubmed publisher |
| Shigemoto Mogami Y, Hoshikawa K, Sato K. Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model. Front Cell Neurosci. 2018;12:494 pubmed publisher |
| Domke L, Franke W. The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system. Cell Tissue Res. 2019;375:451-482 pubmed publisher |
| Dong C, Ubogu E. GDNF enhances human blood-nerve barrier function in vitro via MAPK signaling pathways. Tissue Barriers. 2018;6:1-22 pubmed publisher |
| Luh C, Feiler S, Frauenknecht K, Meyer S, Lubomirov L, Neulen A, et al. The Contractile Apparatus Is Essential for the Integrity of the Blood-Brain Barrier After Experimental Subarachnoid Hemorrhage. Transl Stroke Res. 2018;: pubmed publisher |
| Park M, Lee J, Park K, Jung I, Kim K, Lee Y, et al. Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM. Neuron. 2018;100:167-182.e9 pubmed publisher |
| Zhou Q, Wang Y, Ni P, Chen Y, Dong H, Qian Y. Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2. J Neuroinflammation. 2018;15:248 pubmed publisher |
| Fang M, Zhong W, Song W, Deng Y, Yang D, Xiong B, et al. Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways. Front Pharmacol. 2018;9:823 pubmed publisher |
| Takata F, Dohgu S, Matsumoto J, Machida T, Sakaguchi S, Kimura I, et al. Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro. J Cell Biochem. 2018;119:9055-9063 pubmed publisher |
| Cottier K, Galloway E, Calabrese E, Tome M, Liktor Busa E, Kim J, et al. Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery. Eneuro. 2018;5: pubmed publisher |
| Magaki S, Tang Z, Tung S, Williams C, Lo D, Yong W, et al. The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier. Neurobiol Aging. 2018;70:70-77 pubmed publisher |
| Pena Philippides J, Gardiner A, Caballero Garrido E, Pan R, Zhu Y, Roitbak T. Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation. J Am Heart Assoc. 2018;7: pubmed publisher |
| Abdul Y, Abdelsaid M, Li W, Webb R, Sullivan J, Dong G, et al. Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4. Mol Neurobiol. 2019;56:1607-1617 pubmed publisher |
| Pierce R, Zahr R, Kandil S, Faustino E, Pober J. Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers. Pediatr Crit Care Med. 2018;19:609-618 pubmed publisher |
| Main B, Villapol S, Sloley S, Barton D, Parsadanian M, Agbaegbu C, et al. Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury. Mol Neurodegener. 2018;13:17 pubmed publisher |
| Lin R, Chen F, Wen S, Teng T, Pan Y, Huang H. Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model. J Inflamm (Lond). 2018;15:4 pubmed publisher |
| Cheng Y, Desse S, Martinez A, Worthen R, Jope R, Beurel E. TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice. Brain Behav Immun. 2018;69:556-567 pubmed publisher |
| van Leeuwen L, Evans R, Jim K, Verboom T, Fang X, Bojarczuk A, et al. A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. Biol Open. 2018;7: pubmed publisher |
| Qiu Z, Yang J, Deng G, Fang Y, Li D, Zhang S. Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage. Med Sci Monit. 2018;24:880-890 pubmed |
| Van Skike C, Jahrling J, Olson A, Sayre N, Hussong S, Ungvari Z, et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2018;314:H693-H703 pubmed publisher |
| Palladino S, Helton E, Jain P, Dong C, Crowley M, Crossman D, et al. The Human Blood-Nerve Barrier Transcriptome. Sci Rep. 2017;7:17477 pubmed publisher |
| Mazzoni J, Smith J, Shahriar S, Cutforth T, Ceja B, Agalliu D. The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Neuron. 2017;96:1055-1069.e6 pubmed publisher |
| Kim B, Bee O, McDonagh M, Stebbins M, Palecek S, Doran K, et al. Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells. mSphere. 2017;2: pubmed publisher |
| Zhao J, Hylin M, Kobori N, Hood K, Moore A, Dash P. Post-injury administration of galantamine reduces traumatic brain injury pathology and improves outcome. J Neurotrauma. 2017;: pubmed publisher |
| Lopez Ramirez M, Fonseca G, Zeineddine H, Girard R, Moore T, Pham A, et al. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017;214:3331-3346 pubmed publisher |
| Stebbins M, Lippmann E, Faubion M, Daneman R, Palecek S, Shusta E. Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells. Biotechnol J. 2018;13: pubmed publisher |
| Wang C, Ahmed M, Jiang Q, Lu N, Tan C, Gao Y, et al. Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator. J Pineal Res. 2017;63: pubmed publisher |
| DeStefano J, Xu Z, Williams A, Yimam N, Searson P. Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs). Fluids Barriers CNS. 2017;14:20 pubmed publisher |
| Kim J, Bae S, Lee H, Park J, Kim K. Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality. PLoS ONE. 2017;12:e0182047 pubmed publisher |
| Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw A, et al. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017;127:3136-3151 pubmed publisher |
| Ly H, Verma N, Wu F, Liu M, Saatman K, Nelson P, et al. Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. Ann Neurol. 2017;82:208-222 pubmed publisher |
| Kern M, Günzel D, Aschenbach J, Tedin K, Bondzio A, Lodemann U. Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium. Mediators Inflamm. 2017;2017:2748192 pubmed publisher |
| Cornely R, Schlingmann B, Shepherd W, Chandler J, Neujahr D, Koval M. Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform. Ann N Y Acad Sci. 2017;1397:119-129 pubmed publisher |
| Di Pietro M, Pascuali N, Scotti L, Irusta G, Bas D, May M, et al. In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. Mol Hum Reprod. 2017;23:417-427 pubmed publisher |
| Acharya N, Qi X, Goldwaser E, Godsey G, Wu H, Kosciuk M, et al. Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib. Diab Vasc Dis Res. 2017;14:200-213 pubmed publisher |
| Huggins M, Johnson H, Jin F, N Songo A, Hanson L, Lafrance S, et al. Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria. Infect Immun. 2017;85: pubmed publisher |
| Fiorentino M, Sapone A, Senger S, Camhi S, Kadzielski S, Buie T, et al. Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism. 2016;7:49 pubmed |
| Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed publisher |
| Boussadia B, Gangarossa G, Mselli Lakhal L, Rousset M, de Bock F, Lassere F, et al. Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo. Exp Neurol. 2016;283:39-48 pubmed publisher |
| Northrop N, Halpin L, Yamamoto B. Peripheral ammonia and blood brain barrier structure and function after methamphetamine. Neuropharmacology. 2016;107:18-26 pubmed publisher |
| Devraj K, Poznanovic S, Spahn C, Schwall G, Harter P, Mittelbronn M, et al. BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease. J Cereb Blood Flow Metab. 2016;36:1281-94 pubmed publisher |
| Sang H, Liu L, Wang L, Qiu Z, Li M, Yu L, et al. Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats. Eur J Neurosci. 2016;43:53-65 pubmed publisher |
| Naik P, Sajja R, Prasad S, Cucullo L. Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line. BMC Neurosci. 2015;16:38 pubmed publisher |
| Johnson H, Willenbring R, Jin F, Manhart W, Lafrance S, Pirko I, et al. Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption. PLoS ONE. 2014;9:e111401 pubmed publisher |
| Albert Weissenberger C, Mencl S, Schuhmann M, Salur I, Göb E, Langhauser F, et al. C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation. Front Cell Neurosci. 2014;8:269 pubmed publisher |
| Naik P, Fofaria N, Prasad S, Sajja R, Weksler B, Couraud P, et al. Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?. BMC Neurosci. 2014;15:51 pubmed publisher |
| Ziegler N, Plate K, Liebner S. Analysis of angiogenesis in the developing mouse central nervous system. Methods Mol Biol. 2014;1135:55-68 pubmed publisher |
| Hintsala H, Siponen M, Haapasaari K, Karihtala P, Soini Y. Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin. Int J Clin Exp Pathol. 2013;6:2855-63 pubmed |
| D Agnillo F, Williams M, Moayeri M, Warfel J. Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions. PLoS ONE. 2013;8:e62576 pubmed publisher |
| Kundumani Sridharan V, Dyukova E, Hansen D, Rao G. 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J Biol Chem. 2013;288:15830-42 pubmed publisher |
| Yang Y, Rosenberg G. MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia. Methods Mol Biol. 2011;762:333-45 pubmed publisher |
| Leal E, Martins J, Voabil P, Liberal J, Chiavaroli C, Bauer J, et al. Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. Diabetes. 2010;59:2637-45 pubmed publisher |
| Fang X, Neyrinck A, Matthay M, Lee J. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem. 2010;285:26211-22 pubmed publisher |
| Gralinski L, Ashley S, Dixon S, Spindler K. Mouse adenovirus type 1-induced breakdown of the blood-brain barrier. J Virol. 2009;83:9398-410 pubmed publisher |
| Maria O, Kim J, Gerstenhaber J, Baum B, Tran S. Distribution of tight junction proteins in adult human salivary glands. J Histochem Cytochem. 2008;56:1093-8 pubmed publisher |
| Sheehan G, Kallakury B, Sheehan C, Fisher H, Kaufman R, Ross J. Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas. Hum Pathol. 2007;38:564-9 pubmed |
| Musch M, Walsh Reitz M, Chang E. Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. Am J Physiol Gastrointest Liver Physiol. 2006;290:G222-31 pubmed |
| Weng X, Beyenbach K, Quaroni A. Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium. Am J Physiol Gastrointest Liver Physiol. 2005;288:G705-17 pubmed |
| Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium. J Histochem Cytochem. 2004;52:1037-46 pubmed |
| Rahner C, Fukuhara M, Peng S, Kojima S, Rizzolo L. The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. J Cell Sci. 2004;117:3307-18 pubmed |
| Poliak S, Matlis S, Ullmer C, Scherer S, Peles E. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. J Cell Biol. 2002;159:361-72 pubmed |
