PAR2 Monoclonal Antibody (SAM11) | Invitrogen 35-2300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PAR2 Monoclonal Antibody (SAM11)

catalog :

35-2300

quantity :

100 µg

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SAM11

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; 1:400; fig 1 immunohistochemistry; mouse; 1:500; fig 1	Sitaras N, Rivera J, Noueihed B, Bien AimÃ© M, Zaniolo K, Omri S, et al. Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2. Am J Pathol. 2015;185:581-95 pubmed publisher
immunocytochemistry; human; fig 4	Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed publisher
immunohistochemistry - paraffin section; human immunocytochemistry; human western blot; human; 1:100	Al Eryani K, Cheng J, Abe T, Maruyama S, Yamazaki M, Babkair H, et al. Protease-activated receptor 2 modulates proliferation and invasion of oral squamous cell carcinoma cells. Hum Pathol. 2015;46:991-9 pubmed publisher
immunohistochemistry - paraffin section; human; fig 2	Materazzi S, Pellerito S, Di Serio C, Paglierani M, Naldini A, Ardinghi C, et al. Analysis of protease-activated receptor-1 and -2 in human scar formation. J Pathol. 2007;212:440-9 pubmed
immunohistochemistry - paraffin section; human; 1:50; tbl 1	Ketabchi S, Massi D, Ficarra G, Rubino I, Franchi A, Paglierani M, et al. Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis. Oral Dis. 2007;13:419-25 pubmed
immunocytochemistry; human; fig 4	Wu S, Shin J, Zhang G, Cohen M, Franco A, Sears C. The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor. Infect Immun. 2006;74:5382-90 pubmed
	Richards J, Tang S, Gunsch G, Sul P, Wiet M, Flanigan D, et al. Mast Cell/Proteinase Activated Receptor 2 (PAR2) Mediated Interactions in the Pathogenesis of Discogenic Back Pain. Front Cell Neurosci. 2019;13:294 pubmed publisher
	Bagher M, Larsson Callerfelt A, Rosmark O, Hallgren O, Bjermer L, Westergren Thorsson G. Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2. Cell Commun Signal. 2018;16:59 pubmed publisher
	Ge L, Shenoy S, Lefkowitz R, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem. 2004;279:55419-24 pubmed
	Napoli C, de Nigris F, Wallace J, Hollenberg M, Tajana G, De Rosa G, et al. Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions. J Clin Pathol. 2004;57:513-6 pubmed

product information

Product Type :

Antibody

Product Name :

PAR2 Monoclonal Antibody (SAM11)

Catalog # :

35-2300

Quantity :

100 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent

Species :

Human

Clone :

SAM11

Isotype :

IgG2a

Storage :

-20°C

Description :

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Immunogen :

A synthetic peptide corresponding to the N-terminal of the human PAR2 receptor.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent

Aliases :

coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; F2R like trypsin receptor 1; F2RL1; Gpcr11; Gpr11; G-protein coupled receptor 11; PAR2; PAR-2; protease-activated receptor 2; Protease-activated receptor-2; proteinase-activated receptor 2; Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2; proteinase-activated receptor-2; Proteinase-activated receptor-2 G protein-coupled receptor 11; Proteinase-activated receptor-2, G protein-coupled receptor 11; thrombin receptor-like 1

more info or order :

Invitrogen product webpage