NPC1 Monoclonal Antibody (17B5) | Invitrogen 35-1500Z product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NPC1 Monoclonal Antibody (17B5)

catalog :

35-1500Z

quantity :

100µg

price :

US 345

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17B5

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 1	WoÅ› M, Szczepanowska J, PikuÅ‚a S, Tylki SzymaÅ„ska A, ZabÅ‚ocki K, Bandorowicz PikuÅ‚a J. Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys. 2016;593:50-9 pubmed publisher
	Sztolsztener M, Strzelecka Kiliszek A, Pikula S, Tylki Szymanska A, Bandorowicz Pikula J. Cholesterol as a factor regulating intracellular localization of annexin A6 in Niemann-Pick type C human skin fibroblasts. Arch Biochem Biophys. 2010;493:221-33 pubmed publisher
	Ma X, Hu Y, Mo Z, Li X, Liu X, Xiao J, et al. NO-1886 up-regulates Niemann-Pick C1 protein (NPC1) expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells. Cardiovasc Drugs Ther. 2009;23:199-206 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NPC1 Monoclonal Antibody (17B5)

Catalog # :

35-1500Z

Quantity :

100µg

Price :

US 345

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Western Blot: Assay Dependent

Species :

Human

Clone :

17B5

Isotype :

IgG1

Storage :

-20°C

Description :

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.

Immunogen :

Fragments of Human NPC1 conjugated to a carrier protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Western Blot: Assay Dependent

Aliases :

A430089E03Rik; C85354; Cdig2; D18Ertd139e; D18Ertd723e; FLJ98532; I79_014078; lcsd; Niemann Pick type C1; Niemann-Pick C disease protein; Niemann-Pick C1 protein; Niemann-Pick disease, type C1; Niemann-Pick type C1; nmf164; NPC; NPC intracellular cholesterol transporter 1; NPC1; sphingomyelinosis; spm; truncated Niemann-Pick C1

more info or order :

Invitrogen product webpage