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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CREB Monoclonal Antibody (LB 9)
catalog :
35-0900
quantity :
100µg
price :
US 345.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LB 9
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
more info or order :
Invitrogen product webpage
citations: 5
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; rat; 1:500; fig 6
Oliveira D, Sanada P, Filho A, Conceição G, Cerutti J, Cerutti S. Long-term treatment with standardized extract of Ginkgo biloba L. enhances the conditioned suppression of licking in rats by the modulation of neuronal and glial cell function in the dorsal hippocampus and central amygdala. Neuroscience. 2013;235:70-86 pubmed publisher
  • immunohistochemistry; rat; 1:500; fig 3
Oliveira D, Sanada P, Saragossa Filho A, Innocenti L, Oler G, Cerutti J, et al. Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: behavioral and molecular evidence. Brain Res. 2009;1269:68-89 pubmed publisher
  • western blot; mouse; 0.5 ug/ml; fig 4
Engelking L, Liang G, Hammer R, Takaishi K, Kuriyama H, Evers B, et al. Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005;115:2489-98 pubmed
Muhammad A, Xing B, Liu C, Naji A, Ma X, Simmons R, et al. Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB. Am J Physiol Endocrinol Metab. 2017;313:E148-E166 pubmed publisher
Gao J, Siddoway B, Huang Q, Xia H. Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase. Biochem Biophys Res Commun. 2009;379:1-5 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CREB Monoclonal Antibody (LB 9)
Catalog # :
35-0900
Quantity :
100µg
Price :
US 345.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
ELISA: Assay Dependent, Immunocytochemistry: 1-3 µg/mL, Immunofluorescence: 1-3 µg/mL, Immunohistochemistry: Assay Dependent, Western Blot: 1-3 µg/mL
Species :
Human, Mouse, Rat
Clone :
LB 9
Isotype :
IgG1
Storage :
-20°C
Description :
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
Immunogen :
Recombinant human CREB-A protein
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay Dependent, Immunocytochemistry: 1-3 µg/mL, Immunofluorescence: 1-3 µg/mL, Immunohistochemistry: Assay Dependent, Western Blot: 1-3 µg/mL
Aliases :
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; Creb; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; Cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA