Human TGF-beta 3 (Carrier-Free) Recombinant Protein, eBioscience | Invitrogen 34-8734-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human TGF-beta 3 (Carrier-Free) Recombinant Protein, eBioscience

catalog :

34-8734-82

quantity :

100 µg

price :

US 2150

citations: 3

Reference
Peng Y, Laouar Y, Li M, Green E, Flavell R. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A. 2004;101:4572-7 pubmed
Zheng S, Gray J, Ohtsuka K, Yamagiwa S, Horwitz D. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J Immunol. 2002;169:4183-9 pubmed
Cox D, Maurer T. Transforming growth factor-beta. Clin Immunol Immunopathol. 1997;83:25-30 pubmed

product information

Product Type :

Protein

Product Name :

Human TGF-beta 3 (Carrier-Free) Recombinant Protein, eBioscience

Catalog # :

34-8734-82

Quantity :

100 µg

Pricing :

US 2150

Clonality :

Recombinant

Purity :

Affinity chromatography

Host :

E. coli

Reactivity :

Human

Applications :

Control: Assay-Dependent, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human

Storage :

-20°C

Description :

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Format :

Lyophilized

Applications w/Dilutions :

Control: Assay-Dependent, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3