Human GM-CSF Carrier-Free Recombinant Protein, eBioscience™ | Invitrogen 34-8339-85 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human GM-CSF Carrier-Free Recombinant Protein, eBioscience™

catalog :

34-8339-85

quantity :

500µg

price :

US 2040

citations: 3

Reference
Park B, Zhang H, Zeng Q, Dai J, Keller E, Giordano T, et al. NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med. 2007;13:62-9 pubmed
Dranoff G, Crawford A, Sadelain M, Ream B, Rashid A, Bronson R, et al. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science. 1994;264:713-6 pubmed
Grabstein K, Urdal D, Tushinski R, Mochizuki D, Price V, Cantrell M, et al. Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science. 1986;232:506-8 pubmed

product information

Product Type :

Protein

Product Name :

Human GM-CSF Carrier-Free Recombinant Protein, eBioscience™

Catalog # :

34-8339-85

Quantity :

500µg

Price :

US 2040

Clonality :

Recombinant

Purity :

Affinity chromatography

Host :

E. coli

Reactivity :

Human

Applications :

Control: Assay-Dependent, Functional assay: Assay-Dependent

Species :

Human

Storage :

-80°C

Description :

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

Format :

Liquid

Applications w/Dilutions :

Control: Assay-Dependent, Functional assay: Assay-Dependent

Aliases :

colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Csf2; Csfgm; GMCSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; Granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; Molgramostin; put. GM-CSF; Sargramostim