EphA2 Polyclonal Antibody | Invitrogen 34-7400 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EphA2 Polyclonal Antibody

catalog :

34-7400

quantity :

100 µg

price :

US 482

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay, immunohistochemistry knockout validation

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; fig 4	Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 1a	Stammes M, Prevoo H, Ter Horst M, Groot S, Van De Velde C, Chan A, et al. Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery. Int J Mol Sci. 2017;18: pubmed publisher
proximity ligation assay; human; 1:350; loading ...; fig 3b immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 5a western blot; human; 1:500; loading ...; fig 1a	Efazat G, Novak M, Kaminskyy V, De Petris L, Kanter L, Juntti T, et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget. 2016;7:60332-60347 pubmed publisher
immunoprecipitation; human; loading ...; fig 3f western blot; human; loading ...; fig 3d	Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed publisher
	Zhou L, Lu X, Zhang B, Shi Y, Li Z. EphA2 as a new target for breast cancer and its potential clinical application. Int J Clin Exp Pathol. 2021;14:484-492 pubmed
	Vaught D, Merkel A, Lynch C, Edwards J, Tantawy M, Hilliard T, et al. EphA2 Is a Clinically Relevant Target for Breast Cancer Bone Metastatic Disease. JBMR Plus. 2021;5:e10465 pubmed publisher
	Song W, Kim L, Han W, Hou Y, Edwards D, Wang S, et al. Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer. Mol Cancer Res. 2020;18:1735-1743 pubmed publisher
	Edwards D, Ngwa V, Wang S, Shiuan E, Brantley Sieders D, Kim L, et al. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal. 2017;10: pubmed publisher
	Song W, Hwang Y, Youngblood V, Cook R, Balko J, Chen J, et al. Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers. Oncogene. 2017;36:5620-5630 pubmed publisher
	van Dodewaard De Jong J, Santegoets S, van de Ven P, Versluis J, Verheul H, de Gruijl T, et al. Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells. Oncoimmunology. 2016;5:e1105431 pubmed

product information

Product Type :

Antibody

Product Name :

EphA2 Polyclonal Antibody

Catalog # :

34-7400

Quantity :

100 µg

Price :

US 482

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Isotype :

IgG

Storage :

-20°C

Description :

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Immunogen :

Synthetic peptide derived from the C-terminal region of the human EphA2 receptor protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

ARCC2; AW545284; CTPA; CTPP1; CTRCT6; Eck; EPH receptor A2; Epha2; ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; I79_019726; Myk2; Sek2; Sek-2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2

more info or order :

Invitrogen product webpage