product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Claudin 3 Polyclonal Antibody
catalog :
34-1700
quantity :
100 µg
price :
US 446
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 119
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:150; loading ...; fig 4d
  • western blot; mouse; 1:500; loading ...; fig 4a
Marincola Smith P, Choksi Y, Markham N, Hanna D, Zi J, Weaver C, et al. Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice. Am J Physiol Gastrointest Liver Physiol. 2021;320:G936-G957 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 4g
Gonneaud A, Turgeon N, Boisvert F, Boudreau F, Asselin C. JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice. Cells. 2021;10: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig s7c
Wijshake T, Zou Z, Chen B, Zhong L, Xiao G, Xie Y, et al. Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig 3c
Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed publisher
  • immunocytochemistry; dogs; fig 2
  • western blot; dogs; fig 2
Tokuda S, Hirai T, Furuse M. Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells. PLoS ONE. 2017;12:e0182521 pubmed publisher
  • western blot; rat; 1:1000; fig 1
  • western blot; human; 1:1000; fig 1
  • western blot; mouse; 1:1000; fig 1
Stammler A, Lüftner B, Kliesch S, Weidner W, Bergmann M, Middendorff R, et al. Highly Conserved Testicular Localization of Claudin-11 in Normal and Impaired Spermatogenesis. PLoS ONE. 2016;11:e0160349 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s1a
Porat Shliom N, Tietgens A, Van Itallie C, Vitale Cross L, Jarnik M, Harding O, et al. Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology. 2016;64:1317-29 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:150; fig s8
Campos Y, Qiu X, Gomero E, Wakefield R, Horner L, Brutkowski W, et al. Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier. Nat Commun. 2016;7:11876 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
  • western blot; mouse; 1:1000; fig 5
Dianati E, Poiraud J, Weber Ouellette A, Plante I. Connexins, E-cadherin, Claudin-7 and ?-catenin transiently form junctional nexuses during the post-natal mammary gland development. Dev Biol. 2016;416:52-68 pubmed publisher
  • immunocytochemistry; human; fig 5
Maria O, Liu Y, El Hakim M, Zeitouni A, Tran S. The role of human fibronectin- or placenta basement membrane extract-based gels in favouring the formation of polarized salivary acinar-like structures. J Tissue Eng Regen Med. 2017;11:2643-2657 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
Kobayashi K, Tsugami Y, Matsunaga K, Oyama S, Kuki C, Kumura H. Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells. Biochim Biophys Acta. 2016;1863:2006-16 pubmed publisher
  • immunocytochemistry; mouse; 10 ug/ml; fig 2
Lazarevic I, Engelhardt B. Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids Barriers CNS. 2016;13:2 pubmed publisher
  • western blot; human; 1:500; fig 2
Valcourt U, Carthy J, Okita Y, Alcaraz L, Kato M, Thuault S, et al. Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β. Methods Mol Biol. 2016;1344:147-81 pubmed publisher
  • western blot; mouse
Perdigão Henriques R, Petrocca F, Altschuler G, Thomas M, Le M, Tan S, et al. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes. Oncogene. 2016;35:158-72 pubmed publisher
Tang L, Ma X, Xie L, Zhou H, Yu J, Wang Z, et al. Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway. Mol Nutr Food Res. 2023;67:e2300232 pubmed publisher
Tsugami Y, Nii T, Kobayashi K, Isobe N. Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands. Innate Immun. 2023;29:135-149 pubmed publisher
Higashi T, Stephenson R, Schwayer C, Huljev K, Higashi A, Heisenberg C, et al. Zinc-based Ultrasensitive Microscopic Barrier Assay (ZnUMBA): a live imaging method to detect local barrier breaches. J Cell Sci. 2023;: pubmed publisher
Wittner L, Wagener L, Wiese J, Stolzer I, Krug S, Naschberger E, et al. Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. Int J Mol Sci. 2023;24: pubmed publisher
Xia X, Zhang Y, Cao M, Yu X, Gao L, Qin L, et al. Adverse effect of assisted reproductive technology-related hyperoestrogensim on the secretion and absorption of uterine fluid in superovulating mice during the peri-implantation period. Front Endocrinol (Lausanne). 2023;14:859204 pubmed publisher
Zhao Q, Yu J, Zhou H, Wang X, Zhang C, Hu J, et al. Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism. Signal Transduct Target Ther. 2023;8:40 pubmed publisher
Lian P, Henricks P, Wichers H, Folkerts G, Braber S. Differential Effects of Oligosaccharides, Antioxidants, Amino Acids and PUFAs on Heat/Hypoxia-Induced Epithelial Injury in a Caco-2/HT-29 Co-Culture Model. Int J Mol Sci. 2023;24: pubmed publisher
Awad K, Barmeyer C, Bojarski C, Nagel O, Lee I, Schweiger M, et al. Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M). Cells. 2023;12: pubmed publisher
Higashi T, Saito A, Fukazawa Y, Furuse M, Higashi A, Ono M, et al. EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. J Cell Biol. 2023;222: pubmed publisher
Bagge J, Padma A, Casselbrant A, Hellstr xf6 m M, Oltean M. Mucosal Recovery after Intestinal Transplantation in the Rat: A Sequential Histological and Molecular Assessment. Eur Surg Res. 2023;64:201-210 pubmed publisher
Brunner N, Stein L, Amasheh S. Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins. J Membr Biol. 2023;256:51-61 pubmed publisher
Bekusova V, Zudova T, Fatyykhov I, Fedorova A, Amasheh S, Markov A. Selective Role of TNFα and IL10 in Regulation of Barrier Properties of the Colon in DMH-Induced Tumor and Healthy Rats. Int J Mol Sci. 2022;23: pubmed publisher
Cuevas M, Winters C, Todd M. Microarray Analysis Reveals Overexpression of both Integral Membrane and Cytosolic Tight Junction Genes in Endometrial Cancer Cell Lines. J Cancer. 2022;13:3533-3538 pubmed publisher
Uchida H, Ingalls M, Maruyama E, Johnston C, Hernady E, Faustoferri R, et al. Short-term and bystander effects of radiation on murine submandibular glands. Dis Model Mech. 2022;15: pubmed publisher
Ganieva U, Schneiderman S, Bu P, Beaman K, Dambaeva S. IL-22 regulates endometrial regeneration by enhancing tight junctions and orchestrating extracellular matrix. Front Immunol. 2022;13:955576 pubmed publisher
Saito A, Endo C, Fukazawa Y, Higashi T, Chiba H. Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells. Ann N Y Acad Sci. 2022;1517:234-250 pubmed publisher
Tsugami Y, Nakayama S, Suzuki N, Nii T, Isobe N. Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs. Front Immunol. 2022;13:941333 pubmed publisher
Kwak S, Jang W, Lee S, Kim M, Park S, Cho S, et al. Centella asiatica-Derived Endothelial Paracrine Restores Epithelial Barrier Dysfunction in Radiation-Induced Enteritis. Cells. 2022;11: pubmed publisher
Jhun H, Lee W, Park J, Hwang S, Park H. Transcriptomic Analysis of Testicular Gene Expression in a Dog Model of Experimentally Induced Cryptorchidism. Cells. 2022;11: pubmed publisher
Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, et al. Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat Commun. 2022;13:4985 pubmed publisher
Koumangoye R, Penny P, Delpire E. Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression. Am J Physiol Cell Physiol. 2022;323:C1251-C1263 pubmed publisher
Fujiwara S, Nguyen T, Furuse K, Fukazawa Y, Otani T, Furuse M. Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif. Ann N Y Acad Sci. 2022;1516:85-94 pubmed publisher
Tran O, Wang H, Li S, Malakhov A, Sun Y, Abdul Azees P, et al. Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo. Stem Cell Res Ther. 2022;13:306 pubmed publisher
Gustafson K, Sayar Z, Le H, Gustafson S, Gower A, Modestino A, et al. cyc-DEP: Cyclic immunofluorescence profiling of particles collected using dielectrophoresis. Electrophoresis. 2022;43:1784-1798 pubmed publisher
Zinserling V, Semenova N, Bikmurzina A, Kruglova N, Rybalchenko O, Markov A. SARS-CoV-2-Induced Pathology-Relevance to COVID-19 Pathophysiology. Pathophysiology. 2022;29:281-297 pubmed publisher
Kim S, Jeong Y, Lee G, Lee J, Lee J, Kim C, et al. Differential expression and localization of tight junction proteins in the goat epididymis. J Anim Sci Technol. 2022;64:500-514 pubmed publisher
Wei xdf F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, et al. MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier. Cells. 2022;11: pubmed publisher
Janbazacyabar H, van Bergenhenegouwen J, Varasteh S, Garssen J, Folkerts G, Braber S. Repeated exposure of bronchial epithelial cells to particular matter increases allergen-induced cytokine release and permeability. Cytokine. 2022;154:155878 pubmed publisher
Cho Y, Haraguchi D, Shigetomi K, Matsuzawa K, Uchida S, Ikenouchi J. Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin. J Cell Biol. 2022;221: pubmed publisher
Xue J, Thomas L, Murali S, Levi M, Fenton R, Dominguez Rieg J, et al. Enhanced phosphate absorption in intestinal epithelial cell-specific NHE3 knockout mice. Acta Physiol (Oxf). 2022;234:e13756 pubmed publisher
Yang Y, Fan X, Ji Y, Li J, Dai Z, Wu Z. Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling. Anim Nutr. 2022;8:1-9 pubmed publisher
Yang J, Wei H, Zhou Y, Szeto C, Li C, Lin Y, et al. High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites. Gastroenterology. 2022;162:135-149.e2 pubmed publisher
Seo H, Seong H, Kim G, Jo Y, Cheon S, Song Y, et al. Development of Anti-inflammatory Probiotic Limosilactobacillus reuteri EFEL6901 as Kimchi Starter: in vitro and In vivo Evidence. Front Microbiol. 2021;12:760476 pubmed publisher
Alnajjar S, Nolte I, Becker A, Schille J, Trakooljul N, Frank M, et al. Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention. Int J Mol Sci. 2021;22: pubmed publisher
Oda Y, Takahashi C, Harada S, Nakamura S, Sun D, Kiso K, et al. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021;7:eabj6895 pubmed publisher
Bekusova V, Droessler L, Amasheh S, Markov A. Effects of 1,2-Dimethylhydrazine on Barrier Properties of Rat Large Intestine and IPEC-J2 Cells. Int J Mol Sci. 2021;22: pubmed publisher
MARCHELLETTA R, Krishnan M, Spalinger M, Placone T, Alvarez R, Sayoc Becerra A, et al. T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. J Clin Invest. 2021;131: pubmed publisher
Bieber M, Foerster K, Haefeli W, Pham M, Schuhmann M, Kraft P. Treatment with Edoxaban Attenuates Acute Stroke Severity in Mice by Reducing Blood-Brain Barrier Damage and Inflammation. Int J Mol Sci. 2021;22: pubmed publisher
Droessler L, Cornelius V, Markov A, Amasheh S. Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1. Int J Mol Sci. 2021;22: pubmed publisher
Hoffmann P, Schnepel N, Langeheine M, K xfc nnemann K, Grassl G, Brehm R, et al. Intestinal organoid-based 2D monolayers mimic physiological and pathophysiological properties of the pig intestine. PLoS ONE. 2021;16:e0256143 pubmed publisher
Lian P, Braber S, Varasteh S, Wichers H, Folkerts G. Hypoxia and heat stress affect epithelial integrity in a Caco-2/HT-29 co-culture. Sci Rep. 2021;11:13186 pubmed publisher
Xing C, Wang M, Ajibade A, Tan P, Fu C, Chen L, et al. Microbiota regulate innate immune signaling and protective immunity against cancer. Cell Host Microbe. 2021;29:959-974.e7 pubmed publisher
Uprety T, Sreenivasan C, Bhattarai S, Wang D, Kaushik R, Li F. Isolation and development of bovine primary respiratory cells as model to study influenza D virus infection. Virology. 2021;559:89-99 pubmed publisher
Huang X, Oshima T, Tomita T, Fukui H, Miwa H. Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels. Biology (Basel). 2021;10: pubmed publisher
Levine F, Ogunwobi O. Targeting PVT1 Exon 9 Re-Expresses Claudin 4 Protein and Inhibits Migration by Claudin-Low Triple Negative Breast Cancer Cells. Cancers (Basel). 2021;13: pubmed publisher
Saito A, Higashi T, Fukazawa Y, Otani T, Tauchi M, Higashi A, et al. Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function. Mol Biol Cell. 2021;:mbcE20070464 pubmed publisher
Jia H, Zhang Y, Si X, Jin Y, Jiang D, Dai Z, et al. Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes. Nutrients. 2021;13: pubmed publisher
Tinh N, Sitolo G, Yamamoto Y, Suzuki T. Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model. Foods. 2021;10: pubmed publisher
Aoki K, Harada S, Kawaji K, Matsuzawa K, Uchida S, Ikenouchi J. STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing. Nat Commun. 2021;12:480 pubmed publisher
Xu J, Kausalya P, Van Hul N, Caldez M, Xu S, Ong A, et al. Protective Functions of ZO-2/Tjp2 Expressed in Hepatocytes and Cholangiocytes Against Liver Injury and Cholestasis. Gastroenterology. 2021;160:2103-2118 pubmed publisher
Viheriälä T, Sorvari J, Ihalainen T, Mörö A, Grönroos P, Schlie Wolter S, et al. Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE. Sci Rep. 2021;11:933 pubmed publisher
Munis A, Hyde S, Gill D. A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications. Mol Ther Methods Clin Dev. 2021;20:237-246 pubmed publisher
S xf8 fteland J, Bagge J, Padma A, Casselbrant A, Zhu C, Wang Y, et al. Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine. Am J Transplant. 2021;21:2220-2230 pubmed publisher
Miura K, Oshima T, Ito C, Horikawa T, Yamada M, Tomita T, et al. Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome. J Gastroenterol Hepatol. 2021;36:951-958 pubmed publisher
Winkler L, Blasig R, Breitkreuz Korff O, Berndt P, Dithmer S, Helms H, et al. Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins. J Cereb Blood Flow Metab. 2021;41:132-145 pubmed publisher
Pérez A, Andrade da Costa J, de Souza W, De Souza Ferreira M, Boroni M, de Oliveira I, et al. N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells. Oncol Rep. 2020;44:1649-1661 pubmed publisher
Brunner N, Stein L, Cornelius V, Knittel R, Fallier Becker P, Amasheh S. Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction. Front Physiol. 2020;11:857 pubmed publisher
Singh P, Sanchez Fernandez L, Ramiro Cortijo D, Ochoa Allemant P, Perides G, Liu Y, et al. Maltodextrin-induced intestinal injury in a neonatal mouse model. Dis Model Mech. 2020;13: pubmed publisher
Markov A, Fedorova A, Kravtsova V, Bikmurzina A, Okorokova L, Matchkov V, et al. Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels. Int J Mol Sci. 2020;21: pubmed publisher
Li J, Gordon J, Chen E, Xiao S, Wu L, Zuniga Pflucker J, et al. NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development. Development. 2020;147: pubmed publisher
Love H, Evans R, Humes H, Roy S, Zent R, Harris R, et al. Metformin and Inhibition of TGF-β Stimulate In Vitro Transport in Primary Renal Tubule Cells. Tissue Eng Part A. 2020;: pubmed publisher
Kumai A, Tsugami Y, Wakasa H, Suzuki N, Suzuki T, Nishimura T, et al. Adverse Effects of Coumestrol and Genistein on Mammary Morphogenesis and Future Milk Production Ability of Mammary Epithelial Cells. Adv Biosyst. 2020;4:e1900187 pubmed publisher
Curry J, Tokuda S, McAnulty P, Yu A. Combinatorial expression of claudins in the proximal renal tubule and its functional consequences. Am J Physiol Renal Physiol. 2020;318:F1138-F1146 pubmed publisher
Hoerscher A, Horné F, Dietze R, Berkes E, Oehmke F, Tinneberg H, et al. Localization of claudin-2 and claudin-3 in eutopic and ectopic endometrium is highly similar. Arch Gynecol Obstet. 2020;301:1003-1011 pubmed publisher
Kobayashi K, Tsugami Y, Suzuki N, Suzuki T, Nishimura T. Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro. Toxicol In Vitro. 2020;63:104741 pubmed publisher
Seyed Toutounchi N, Hogenkamp A, Varasteh S, Van t Land B, Garssen J, Kraneveld A, et al. Fusarium Mycotoxins Disrupt the Barrier and Induce IL-6 Release in a Human Placental Epithelium Cell Line. Toxins (Basel). 2019;11: pubmed publisher
Mehdizadeh Gohari I, Li J, Navarro M, Uzal F, McClane B. Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells. Toxins (Basel). 2019;11: pubmed publisher
Dierks A, Bader A, Lehrich T, Ngezahayo A. Stimulation of the A2B Adenosine Receptor Subtype Enhances Connexin26 Hemichannel Activity in Small Airway Epithelial Cells. Cell Physiol Biochem. 2019;53:606-622 pubmed publisher
Otani T, Nguyen T, Tokuda S, Sugihara K, Sugawara T, Furuse K, et al. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J Cell Biol. 2019;218:3372-3396 pubmed publisher
Schuhmann M, Stoll G, Papp L, Bohr A, Volkmann J, Fluri F. Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats. Int J Mol Sci. 2019;20: pubmed publisher
Luo S, Terciolo C, Bracarense A, Payros D, Pinton P, Oswald I. In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier. Environ Int. 2019;132:105082 pubmed publisher
Yang R, Hui Q, Jiang Q, Liu S, Zhang H, Wu J, et al. Effect of Manitoba-Grown Red-Osier Dogwood Extracts on Recovering Caco-2 Cells from H2O2-Induced Oxidative Damage. Antioxidants (Basel). 2019;8: pubmed publisher
Danzinger S, Tan Y, Rudas M, Kastner M, Weingartshofer S, Muhr D, et al. Association of Cytokeratin 5 and Claudin 3 expression with BRCA1 and BRCA2 germline mutations in women with early breast cancer. BMC Cancer. 2019;19:695 pubmed publisher
Van Itallie C, Lidman K, Tietgens A, Anderson J. Newly synthesized claudins but not occludin are added to the basal side of the tight junction. Mol Biol Cell. 2019;30:1406-1424 pubmed publisher
Nyeng P, Heilmann S, Löf Öhlin Z, Pettersson N, Hermann F, Reynolds A, et al. p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. Dev Cell. 2019;: pubmed publisher
Lashhab R, Rumley A, Arutyunov D, Rizvi M, You C, Dimke H, et al. The kidney anion exchanger 1 affects tight junction properties via claudin-4. Sci Rep. 2019;9:3099 pubmed publisher
Nakamura S, Irie K, Tanaka H, Nishikawa K, Suzuki H, Saitoh Y, et al. Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun. 2019;10:816 pubmed publisher
Chen H, Lu R, Zhang Y, Sun J. Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs. Tissue Barriers. 2018;6:1-13 pubmed publisher
Garcia Pradas L, Gleiser C, Wizenmann A, Wolburg H, Mack A. Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons. Front Mol Neurosci. 2018;11:367 pubmed publisher
Becker A, Leskau M, Schlingmann Molina B, Hohmeier S, Alnajjar S, Murua Escobar H, et al. Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique. Sci Rep. 2018;8:14963 pubmed publisher
Danzinger S, Tan Y, Rudas M, Kastner M, Weingartshofer S, Muhr D, et al. Differential Claudin 3 and EGFR Expression Predicts BRCA1 Mutation in Triple-Negative Breast Cancer. Cancer Invest. 2018;36:378-388 pubmed publisher
Janardhan K, Jensen H, Clayton N, Herbert R. Immunohistochemistry in Investigative and Toxicologic Pathology. Toxicol Pathol. 2018;46:488-510 pubmed publisher
Hollenbach J, Jung K, Noelke J, Gasse H, Pfarrer C, Koy M, et al. Loss of connexin43 in murine Sertoli cells and its effect on blood-testis barrier formation and dynamics. PLoS ONE. 2018;13:e0198100 pubmed publisher
Shigetomi K, Ono Y, Inai T, Ikenouchi J. Adherens junctions influence tight junction formation via changes in membrane lipid composition. J Cell Biol. 2018;217:2373-2381 pubmed publisher
Emmerson E, May A, Berthoin L, Cruz Pacheco N, Nathan S, Mattingly A, et al. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018;10: pubmed publisher
Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, et al. Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis. J Invest Dermatol. 2018;138:1279-1287 pubmed publisher
Shimada H, Satohisa S, Kohno T, Konno T, Takano K, Takahashi S, et al. Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer. Oncol Lett. 2017;14:6776-6782 pubmed publisher
Mathew S, Palamuttam R, Mernaugh G, Ramalingam H, Lu Z, Zhang M, et al. Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development. Development. 2017;144:4148-4158 pubmed publisher
Ahmad R, Rah B, Bastola D, Dhawan P, Singh A. Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching. Sci Rep. 2017;7:5125 pubmed publisher
Kern M, Günzel D, Aschenbach J, Tedin K, Bondzio A, Lodemann U. Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium. Mediators Inflamm. 2017;2017:2748192 pubmed publisher
Bardet C, Ribes S, Wu Y, Diallo M, Salmon B, Breiderhoff T, et al. Claudin Loss-of-Function Disrupts Tight Junctions and Impairs Amelogenesis. Front Physiol. 2017;8:326 pubmed publisher
Rondanino C, Maouche A, Dumont L, Oblette A, Rives N. Establishment, maintenance and functional integrity of the blood-testis barrier in organotypic cultures of fresh and frozen/thawed prepubertal mouse testes. Mol Hum Reprod. 2017;23:304-320 pubmed publisher
Machado A, Rodríguez Expósito E, Lopez M, Hernandez M. Phylogenetic analysis of the genus Laparocerus, with comments on colonisation and diversification in Macaronesia (Coleoptera, Curculionidae, Entiminae). Zookeys. 2017;:1-77 pubmed publisher
Tokuda S, Hirai T, Furuse M. Effects of Osmolality on Paracellular Transport in MDCK II Cells. PLoS ONE. 2016;11:e0166904 pubmed publisher
Shukla P, Chaudhry K, Mir H, Gangwar R, Yadav N, Manda B, et al. Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. BMC Cancer. 2016;16:189 pubmed publisher
Martínez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher
Todd M, Petty H, King J, Piana Marshall B, Sheller R, Cuevas M. Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines. Oncol Lett. 2015;10:156-162 pubmed
Lu Z, Kim D, Fan J, Lu Q, Verbanac K, Ding L, et al. A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment. Mol Cancer. 2015;14:120 pubmed publisher
Akbari P, Braber S, Alizadeh A, Verheijden K, Schoterman M, Kraneveld A, et al. Galacto-oligosaccharides Protect the Intestinal Barrier by Maintaining the Tight Junction Network and Modulating the Inflammatory Responses after a Challenge with the Mycotoxin Deoxynivalenol in Human Caco-2 Cell Monolayers and B6C3F1 Mice. J Nutr. 2015;145:1604-13 pubmed publisher
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Staat C, Coisne C, Dabrowski S, Stamatovic S, Andjelkovic A, Wolburg H, et al. Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers. Biomaterials. 2015;54:9-20 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
Claudin 3 Polyclonal Antibody
Catalog # :
34-1700
Quantity :
100 µg
Price :
US 446
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Human, Mouse
Applications :
ELISA: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000
Species :
Canine, Human, Mouse
Isotype :
IgG
Storage :
-20°C
Description :
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
Immunogen :
Synthetic peptide derived from the C-terminal region of mouse Claudin-3
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000
Aliases :
AI182374; C7orf1; claudin 3; claudin-3; CLDN3; clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-R2; CPE-receptor 2; CPETR2; hRVP1; integral membrane protein claudin-3; mRVP1; Rat ventral prostate.1 protein; Rat ventral prostate.1 protein homolog; RVP1; tight junction protein; ventral prostate.1 protein; ventral prostate.1 protein homolog; ventral prostate.1-like protein
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA