| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3a
| Zhou H, Qin L, Jiang Q, Murray K, Zhang H, Li B, et al. Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nat Commun. 2021;12:504 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 5e
- western blot; mouse; fig 4f
| Peroutka R, Buzza M, Mukhopadhyay S, Johnson T, Driesbaugh K, Antalis T. Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis. PLoS ONE. 2020;15:e0234407 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2e, 2h
| Li C, Chen W, Wang J, Xia M, Jia Z, Guo C, et al. Nicotinamide riboside rescues angiotensin II-induced cerebral small vessel disease in mice. CNS Neurosci Ther. 2020;26:438-447 pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig s3g
| Diéguez Hurtado R, Kato K, Giaimo B, Nieminen Kelhä M, Arf H, Ferrante F, et al. Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019;10:2817 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3b
| Benz F, Wichitnaowarat V, Lehmann M, Germano R, Mihova D, Macas J, et al. Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. elife. 2019;8: pubmed publisher |
- immunohistochemistry; mouse; 1:500; loading ...; tbl 1
| Bassett E, Tokarew N, Allemano E, Mazerolle C, Morin K, Mears A, et al. Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. elife. 2016;5: pubmed publisher |
- immunohistochemistry; mouse; 1:400; loading ...; fig 6c
| Gautam J, Zhang X, Yao Y. The role of pericytic laminin in blood brain barrier integrity maintenance. Sci Rep. 2016;6:36450 pubmed publisher |
- immunocytochemistry; human; fig s2
| Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100; loading ...; fig 2i
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2b
| Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed publisher |
- western blot; human; fig 3
| Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed publisher |
- western blot; mouse; fig 3a
| Zhang Z, Yan J, Shi H. Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke. Neurobiol Dis. 2016;95:82-92 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:500; fig s2
| Szalay G, Martinecz B, Lénárt N, Kornyei Z, Orsolits B, Judák L, et al. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun. 2016;7:11499 pubmed publisher |
- immunocytochemistry; human; 1:50; fig 4
- western blot; human; 1:500; fig 4
| Liu W, Cai H, Lin M, Zhu L, Gao L, Zhong R, et al. MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1. Exp Cell Res. 2016;343:248-257 pubmed publisher |
- immunohistochemistry - paraffin section; domestic horse; fig 5
- western blot; domestic horse; 1:1000; fig 1
| Lee B, Kang H, Lee D, Ahn C, Jeung E. Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues. J Vet Sci. 2016;17:445-451 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:400; fig 4
| Teng F, Zhu L, Su J, Zhang X, Li N, Nie Z, et al. Neuroprotective Effects of Poly(ADP-ribose)polymerase Inhibitor Olaparib in Transient Cerebral Ischemia. Neurochem Res. 2016;41:1516-26 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:500; fig 5
| Honig G, Mader S, Chen H, Porat A, Ochani M, Wang P, et al. Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve. PLoS ONE. 2016;11:e0144215 pubmed publisher |
| Tiruppathi C, Wang D, Ansari M, Bano S, Tsukasaki Y, Mukhopadhyay A, et al. Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions. Nat Commun. 2023;14:6582 pubmed publisher |
| Freitas Andrade M, Comin C, Van Dyken P, Ouellette J, Raman Nair J, Blakeley N, et al. Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation. Nat Commun. 2023;14:4965 pubmed publisher |
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| Alshaikh R, Zaki R, El Din R, Ryan K, Waeber C. Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy. J Pharmacol Exp Ther. 2023;386:224-241 pubmed publisher |
| Lin J, Xu Y, Guo P, Chen Y, Zhou J, Xia M, et al. CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice. J Transl Med. 2023;21:196 pubmed publisher |
| Li Y, Liu B, Zhao T, Quan X, Han Y, Cheng Y, et al. Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke. J Nanobiotechnology. 2023;21:70 pubmed publisher |
| Lee E, Lee E, Kong E, Chon H, Llaiqui Condori M, Park C, et al. An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone. Exp Mol Med. 2023;55:470-484 pubmed publisher |
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| Wang P, Ren Q, Shi M, Liu Y, Bai H, Chang Y. Overexpression of Mitochondrial Ferritin Enhances Blood-Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells. Antioxidants (Basel). 2022;11: pubmed publisher |
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| Zhang Y, Wang L, Pan Q, Yang X, Cao Y, Yan J, et al. Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis. Fluids Barriers CNS. 2022;19:57 pubmed publisher |
| Kobutree P, Tothonglor A, Roumwong A, Jindatip D, Agthong S. Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin. Folia Morphol (Warsz). 2022;: pubmed publisher |
| Greene C, Campbell M. Immunohistochemical Analysis of Tight Junction Proteins. Methods Mol Biol. 2022;2492:307-314 pubmed publisher |
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| Deissler H, Rehak M, Wolf A. Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence. Biomolecules. 2022;12: pubmed publisher |
| Kim B, Canonica J, Roudnicky F, Westenskow P. Preventing VEGF-Mediated Vascular Permeability by Experimentally Potentiating BBB Characteristics in Endothelial Cells. Methods Mol Biol. 2022;2475:259-274 pubmed publisher |
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| Lin P, Tan R, Yu P, Li Y, Mo Y, Li W, et al. Autophagic degradation of claudin-5 mediated by its binding to a Clostridium perfringens enterotoxin fragment modulates endothelial barrier permeability. FEBS Lett. 2022;596:924-937 pubmed publisher |
| Chang J, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols B, et al. Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier. Cell Rep Med. 2022;3:100497 pubmed publisher |
| Dion Albert L, Cadoret A, Doney E, Kaufmann F, Dudek K, Daigle B, et al. Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nat Commun. 2022;13:164 pubmed publisher |
| He X, Huang Y, Liu Y, Zhang X, Yue P, Ma X, et al. BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury. Int J Mol Med. 2022;49: pubmed publisher |
| Yu R, Kim N, Li Y, Jeong J, Park S, Zhou B, et al. Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. Transl Stroke Res. 2022;13:142-159 pubmed publisher |
| Sasson E, Anzi S, Bell B, Yakovian O, Zorsky M, Deutsch U, et al. Nano-scale architecture of blood-brain barrier tight-junctions. elife. 2021;10: pubmed publisher |
| Geng X, Srinivasan S. Whole-mount Immunohistochemistry to Visualize Mouse Embryonic Dermal Lymphatic Vasculature. Bio Protoc. 2021;11:e4186 pubmed publisher |
| Spieth L, Berghoff S, Stumpf S, Winchenbach J, Michaelis T, Watanabe T, et al. Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport. Neurooncol Adv. 2021;3:vdab140 pubmed publisher |
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| Wang Y, Niu A, Pan Y, Cao S, Terker A, Wang S, et al. Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq. Diabetes. 2021;70:2377-2390 pubmed publisher |
| Storck S, Kurtyka M, Pietrzik C. Brain endothelial LRP1 maintains blood-brain barrier integrity. Fluids Barriers CNS. 2021;18:27 pubmed publisher |
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| Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G. Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep. 2021;35:109168 pubmed publisher |
| Khan A, Ni W, Lopez Giraldez F, Kluger M, Pober J, Pierce R. Tumor necrosis factor-induced ArhGEF10 selectively activates RhoB contributing to human microvascular endothelial cell tight junction disruption. FASEB J. 2021;35:e21627 pubmed publisher |
| Desmarais F, Hervé V, Bergeron K, Ravaut G, Perrotte M, Fyfe Desmarais G, et al. Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. Int J Mol Sci. 2021;22: pubmed publisher |
| Manian K, Galloway C, Dalvi S, Emanuel A, Mereness J, Black W, et al. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration. Cell Stem Cell. 2021;28:846-862.e8 pubmed publisher |
| Zhou Q, Vega Leonel J, Santoso M, Wilson C, van den Berg N, Chan C, et al. Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma. Sci Rep. 2021;11:5710 pubmed publisher |
| Yang P, Tian H, Zou Y, Chambon P, Ichinose H, Honig G, et al. Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis. Front Immunol. 2021;12:616583 pubmed publisher |
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| Wellens S, Dehouck L, Chandrasekaran V, Singh P, Loiola R, Sevin E, et al. Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021;73:105112 pubmed publisher |
| Uzunallı G, Herr S, Dieterly A, Shi R, Lyle L. Structural disruption of the blood-brain barrier in repetitive primary blast injury. Fluids Barriers CNS. 2021;18:2 pubmed publisher |
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| Liu Y, Zhang H, Wang S, Guo Y, Fang X, Zheng B, et al. Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction. Am J Physiol Heart Circ Physiol. 2021;320:H549-H562 pubmed publisher |
| Koh S, Ooi S, Lui N, Qiong C, Ho L, Cheah I, et al. Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury. Neuromolecular Med. 2021;23:184-198 pubmed publisher |
| Hollier P, Chapouly C, Diop A, Guimbal S, Cornuault L, Gadeau A, et al. Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability. Cardiovasc Res. 2021;117:2489-2501 pubmed publisher |
| Nagatake T, Zhao Y, Ito T, Itoh M, Kometani K, Furuse M, et al. Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export. Int Immunol. 2021;33:171-182 pubmed publisher |
| Vion A, Perovic T, Petit C, Hollfinger I, Bartels Klein E, Frampton E, et al. Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways. Front Physiol. 2020;11:623769 pubmed publisher |
| Burek M, Burmester S, Salvador E, Moller Ehrlich K, Schneider R, Roewer N, et al. Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood-Brain Barrier in vivo and in vitro. Front Physiol. 2020;11:569881 pubmed publisher |
| Greene C, Hanley N, Campbell M. Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders. Transl Psychiatry. 2020;10:373 pubmed publisher |
| Pellegrini L, Albecka A, Mallery D, Kellner M, Paul D, Carter A, et al. SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Cell Stem Cell. 2020;27:951-961.e5 pubmed publisher |
| Frye M, Stritt S, Ortsäter H, Hernandez Vasquez M, Kaakinen M, Vicente A, et al. EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. elife. 2020;9: pubmed publisher |
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| Brunner N, Stein L, Cornelius V, Knittel R, Fallier Becker P, Amasheh S. Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction. Front Physiol. 2020;11:857 pubmed publisher |
| Parchur A, Fang Z, Jagtap J, Sharma G, Hansen C, Shafiee S, et al. NIR-II window tracking of hyperglycemia induced intracerebral hemorrhage in cerebral cavernous malformation deficient mice. Biomater Sci. 2020;8:5133-5144 pubmed publisher |
| Clé M, Desmetz C, Barthelemy J, Martin M, Constant O, Maarifi G, et al. Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier. MBio. 2020;11: pubmed publisher |
| Spampinato S, Merlo S, Fagone E, Fruciano M, Sano Y, Kanda T, et al. Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid. Front Mol Neurosci. 2020;13:120 pubmed publisher |
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| Díaz Coránguez M, Lin C, Liebner S, Antonetti D. Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability. J Biol Chem. 2020;295:4647-4660 pubmed publisher |
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| He Q, Liu H, Huang C, Wang R, Luo M, Lu W. Herpes Simplex Virus 1-Induced Blood-Brain Barrier Damage Involves Apoptosis Associated With GM130-Mediated Golgi Stress. Front Mol Neurosci. 2020;13:2 pubmed publisher |
| Kim Y, Lee S, Zhang H, Lee S, Kim H, Kim Y, et al. CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation. J Neuroinflammation. 2020;17:48 pubmed publisher |
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| Castro Dias M, Coisne C, Baden P, Enzmann G, Garrett L, Becker L, et al. Claudin-12 is not required for blood-brain barrier tight junction function. Fluids Barriers CNS. 2019;16:30 pubmed publisher |
| Spampinato S, Merlo S, Fagone E, Fruciano M, Barbagallo C, Kanda T, et al. Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model. Front Cell Neurosci. 2019;13:337 pubmed publisher |
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| Corem N, Anzi S, Gelb S, Ben Zvi A. Leptin receptor deficiency induces early, transient and hyperglycaemia-independent blood-brain barrier dysfunction. Sci Rep. 2019;9:2884 pubmed publisher |
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| Hsieh J, Rathore A, Soundarajan G, St John A. Japanese encephalitis virus neuropenetrance is driven by mast cell chymase. Nat Commun. 2019;10:706 pubmed publisher |
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| Bieber M, Schuhmann M, Volz J, Kumar G, Vaidya J, Nieswandt B, et al. Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function. Stroke. 2019;50:478-486 pubmed publisher |
| Deissler H, Lang G, Lang G. Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation. Graefes Arch Clin Exp Ophthalmol. 2019;257:83-94 pubmed publisher |
| Feng S, Zou L, Wang H, He R, Liu K, Zhu H. RhoA/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability. Molecules. 2018;23: pubmed publisher |
| van der Wijk A, Canning P, van Heijningen R, Vogels I, Van Noorden C, Klaassen I, et al. Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood-retinal barrier. Acta Ophthalmol. 2019;97:214-224 pubmed publisher |
| Che Y, Geng B, Xu Y, Miao X, Chen L, Mu X, et al. Helicobacter pylori-induced exosomal MET educates tumour-associated macrophages to promote gastric cancer progression. J Cell Mol Med. 2018;22:5708-5719 pubmed publisher |
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