ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor 594 | Invitrogen 339194 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor 594

catalog :

339194

quantity :

100 ug

price :

US 538.00

clonality :

monoclonal

host :

mouse

conjugate :

Alexa Fluor 594

clone name :

ZO1-1A12

reactivity :

human, mouse, dogs, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 29

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:250; loading ...	Yang H, Lee S, Yang D, Dai H, Zhang Y, Han L, et al. Deletions in CWH43 cause idiopathic normal pressure hydrocephalus. EMBO Mol Med. 2021;13:e13249 pubmed publisher
immunocytochemistry; mouse	Hyun Jo D, Lee R, Hyoung Kim J, Oh Jun H, Geol Lee T, Hun Kim J. Real-time estimation of paracellular permeability of cerebral endothelial cells by capacitance sensor array. Sci Rep. 2015;5:11014 pubmed publisher
immunohistochemistry - frozen section; chicken immunohistochemistry - frozen section; mouse; 1:100; fig 6	Prin F, Serpente P, Itasaki N, Gould A. Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation. Development. 2014;141:1492-502 pubmed publisher
	Daley R, Maddipatla V, Ghosh S, Chowdhury O, Hose S, Zigler J, et al. Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy. Cell Death Discov. 2023;9:243 pubmed publisher
	Jang H, Kim S, Park K, Kim J. Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium. Cell Death Dis. 2023;14:334 pubmed publisher
	Fullen A, Gutierrez Ferman J, Rayner R, Kim S, Chen P, Dubey P, et al. Architecture and matrix assembly determinants of Bordetella pertussis biofilms on primary human airway epithelium. PLoS Pathog. 2023;19:e1011193 pubmed publisher
	Liu H, Stepicheva N, Ghosh S, Shang P, Chowdhury O, Daley R, et al. Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy. Nat Commun. 2022;13:6045 pubmed publisher
	Efraim Y, Chen F, Cheong K, Gaylord E, McNamara N, Knox S. A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration. Cell Rep. 2022;40:111307 pubmed publisher
	Sabatier P, Beusch C, Saei A, Aoun M, Moruzzi N, Coelho A, et al. An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation. Nat Commun. 2021;12:6558 pubmed publisher
	Shang P, Stepicheva N, Liu H, Chowdhury O, Franks J, Sun M, et al. A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD. Int J Mol Sci. 2021;22: pubmed publisher
	Jang H, Jo D, Lee S, Cho C, Jeong Y, Jung Y, et al. High-purity production and precise editing of DNA base editing ribonucleoproteins. Sci Adv. 2021;7: pubmed publisher
	Strelez C, Chilakala S, Ghaffarian K, Lau R, Spiller E, Ung N, et al. Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread. iScience. 2021;24:102509 pubmed publisher
	Si L, Bai H, Rodas M, Cao W, Oh C, Jiang A, et al. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nat Biomed Eng. 2021;5:815-829 pubmed publisher
	Hernandez M, Recalde S, Gonz xe1 lez Zamora J, Bilbao Malav xe9 V, S xe1 enz de Viteri M, Bezunartea J, et al. Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration. Nutrients. 2021;13: pubmed publisher
	V kovski P, Gultom M, Kelly J, Steiner S, Russeil J, Mangeat B, et al. Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium. PLoS Biol. 2021;19:e3001158 pubmed publisher
	Bai H, Zhou R, Barravecchia M, Norman R, Friedman A, Yu D, et al. The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. JCI Insight. 2021;6: pubmed publisher
	Fernández Robredo P, González Zamora J, Recalde S, Bilbao Malavé V, Bezunartea J, Hernandez M, et al. Vitamin D Protects against Oxidative Stress and Inflammation in Human Retinal Cells. Antioxidants (Basel). 2020;9: pubmed publisher
	Ogura S, Baldeosingh R, Bhutto I, Kambhampati S, Scott McLeod D, Edwards M, et al. A role for mast cells in geographic atrophy. FASEB J. 2020;34:10117-10131 pubmed publisher
	Hiebl V, Schachner D, Ladurner A, Heiss E, Stangl H, Dirsch V. Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations. Biol Proced Online. 2020;22:7 pubmed publisher
	Marescotti D, Bovard D, Morelli M, Sandoz A, Luettich K, Frentzel S, et al. In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air-Liquid Interface Cultures. SLAS Technol. 2020;25:247-252 pubmed publisher
	Lee S, Chung M, Lee S, Jeon N. 3D brain angiogenesis model to reconstitute functional human blood-brain barrier in vitro. Biotechnol Bioeng. 2020;117:748-762 pubmed publisher
	Ibeh C, Yiu A, Kanaras Y, Paal E, Birnbaumer L, Jose P, et al. Evidence for a regulated Ca2+ entry in proximal tubular cells and its implication in calcium stone formation. J Cell Sci. 2019;132: pubmed publisher
	Rayner R, Makena P, Prasad G, Cormet Boyaka E. Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model Studies. Sci Rep. 2019;9:500 pubmed publisher
	Soragni E, Petrosyan L, Rinkoski T, Wieben E, Baratz K, Fautsch M, et al. Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2018;59:1888-1896 pubmed publisher
	Davis R, Kechele D, Blakeney E, Pawlak J, Caron K. Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation. JCI Insight. 2017;2:e92465 pubmed publisher
	Pei L, Solis G, Nguyen M, Kamat N, Magenheimer L, Zhuo M, et al. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016;126:2509-18 pubmed publisher
	Radeke M, Radeke C, Shih Y, Hu J, Bok D, Johnson L, et al. Restoration of mesenchymal retinal pigmented epithelial cells by TGF? pathway inhibitors: implications for age-related macular degeneration. Genome Med. 2015;7:58 pubmed publisher
	Bonastre E, Verdura S, Zondervan I, Facchinetti F, Lantuejoul S, Chiara M, et al. PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion. Cancer Res. 2015;75:1287-97 pubmed publisher
	Lemcke H, Nittel M, Weiss D, Kuznetsov S. Neuronal differentiation requires a biphasic modulation of gap junctional intercellular communication caused by dynamic changes of connexin43 expression. Eur J Neurosci. 2013;38:2218-28 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor 594

Catalog # :

339194

Quantity :

100 ug

Price :

US 538.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human

Applications :

ELISA: 0.1-1.0 ug/mL, Immunocytochemistry: 1-10 ug/mL, Western Blot: 1-2 ug/mL

Species :

Canine, Human

Clone :

ZO1-1A12

Isotype :

IgG1, kappa

Storage :

4 C, store in dark

Description :

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

Immunogen :

Human recombinant ZO-1 fusion protein encompassing amino acids 334-634

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1-1.0 ug/mL, Immunocytochemistry: 1-10 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1

more info or order :

Invitrogen product webpage