Occludin Monoclonal Antibody (OC-3F10), Alexa Fluor 594 | Invitrogen 331594 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Occludin Monoclonal Antibody (OC-3F10), Alexa Fluor 594

catalog :

331594

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

Alexa Fluor 594

clone name :

OC-3F10

reactivity :

human, mouse, rat, dogs

application :

western blot, ELISA, immunocytochemistry

citations: 10

Reference
Jennings P, Carta G, Singh P, da Costa Pereira D, Fehér A, Dinnyes A, et al. Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2023;39:1773-1793 pubmed publisher
Vendrov A, Stevenson M, Lozhkin A, Hayami T, Holland N, Yang X, et al. Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension. Antioxid Redox Signal. 2022;36:550-566 pubmed publisher
Lee S, Teng Y, Son M, Ku B, Hwang H, Tergaonkar V, et al. Three-Dimensional Aggregated Spheroid Model of Hepatocellular Carcinoma Using a 96-Pillar/Well Plate. Molecules. 2021;26: pubmed publisher
Luvanda M, Posch W, Noureen A, Lafon E, Zaderer V, Lass Florl C, et al. Dexamethasone Creates a Suppressive Microenvironment and Promotes Aspergillus fumigatus Invasion in a Human 3D Epithelial/Immune Respiratory Model. J Fungi (Basel). 2021;7: pubmed publisher
Bai H, Zhou R, Barravecchia M, Norman R, Friedman A, Yu D, et al. The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. JCI Insight. 2021;6: pubmed publisher
Torices S, Roberts S, Park M, Malhotra A, Toborek M. Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes. FASEB J. 2020;34:16319-16332 pubmed publisher
Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, et al. Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium. Cell Rep. 2020;33:108246 pubmed publisher
Yu Y, Lu J, Oliphant K, Gupta N, Claud K, Lu L. Maternal administration of probiotics promotes gut development in mouse offsprings. PLoS ONE. 2020;15:e0237182 pubmed publisher
Campos Y, Qiu X, Gomero E, Wakefield R, Horner L, Brutkowski W, et al. Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier. Nat Commun. 2016;7:11876 pubmed publisher
Huh D, Kim H, Fraser J, Shea D, Khan M, Bahinski A, et al. Microfabrication of human organs-on-chips. Nat Protoc. 2013;8:2135-57 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Occludin Monoclonal Antibody (OC-3F10), Alexa Fluor 594

Catalog # :

331594

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rat

Applications :

ELISA: 0.1-1 ug/mL, Immunocytochemistry: 2.5-5 ug/mL, Western Blot: 0.1-1 ug/mL

Species :

Canine, Human, Mouse, Rat

Clone :

OC-3F10

Isotype :

IgG1, kappa

Storage :

4 C, store in dark

Description :

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.

Immunogen :

GST-fusion protein consisting of the C-terminal region (~150 aa) of human occludin.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1-1 ug/mL, Immunocytochemistry: 2.5-5 ug/mL, Western Blot: 0.1-1 ug/mL

Aliases :

AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein