Cytochrome C Monoclonal Antibody (7H8.2C12) | Invitrogen 33-8500 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cytochrome C Monoclonal Antibody (7H8.2C12)

catalog :

33-8500

quantity :

200 µg

price :

US 405.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7H8.2C12

reactivity :

human, mouse, rat, fruit fly , Xenopus laevis, domestic horse

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
western blot; Xenopus laevis; 1:1000; fig 7	Roque C, Wong H, Lin J, Holt C. Tumor protein Tctp regulates axon development in the embryonic visual system. Development. 2016;143:1134-48 pubmed publisher
western blot; human; 1:1000	Stefano G, Mantione K, Capellan L, Casares F, Challenger S, Ramin R, et al. Morphine stimulates nitric oxide release in human mitochondria. J Bioenerg Biomembr. 2015;47:409-17 pubmed publisher
immunoprecipitation; human	Hedgepeth S, Garcia M, Wagner L, Rodriguez A, Chintapalli S, Snyder R, et al. The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release. J Biol Chem. 2015;290:7304-13 pubmed publisher
western blot; rat; 1:1000; fig 15	Guerrero Beltrán C, Calderon Oliver M, Martínez Abundis E, Tapia E, Zarco Márquez G, Zazueta C, et al. Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and ? glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 . Toxicol Lett. 2010;199:80-92 pubmed publisher
western blot; rat; 1:2000; tbl 1	Zucchini Pascal N, De Sousa G, Rahmani R. Lindane and cell death: at the crossroads between apoptosis, necrosis and autophagy. Toxicology. 2009;256:32-41 pubmed publisher
immunohistochemistry; fruit fly ; 1:200 western blot; fruit fly ; 1:500	Abdelwahid E, Yokokura T, Krieser R, Balasundaram S, Fowle W, White K. Mitochondrial disruption in Drosophila apoptosis. Dev Cell. 2007;12:793-806 pubmed
western blot; rat; 1:400; fig 6	Tanaka S, Takehashi M, Iida S, Kitajima T, Kamanaka Y, Stedeford T, et al. Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. J Neurochem. 2005;95:179-90 pubmed
western blot; mouse; fig 4	Abarca Rojano E, Rosas Medina P, Zamudio Cortéz P, Mondragón Flores R, Sánchez García F. Mycobacterium tuberculosis virulence correlates with mitochondrial cytochrome c release in infected macrophages. Scand J Immunol. 2003;58:419-27 pubmed
western blot; rat; 1:200; fig 3	Olichon A, Emorine L, Descoins E, Pelloquin L, Brichese L, Gas N, et al. The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett. 2002;523:171-6 pubmed
western blot; human; fig 2	Tang D, Lahti J, Grenet J, Kidd V. Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J Biol Chem. 1999;274:7245-52 pubmed
	Petkovic A, Jakovljevic V, Bradic J, Jeremic J, Jeremic N, Nikolic Turnic T, et al. The Effects of Potassium Cyanide on the Functional Recovery of Isolated Rat Hearts after Ischemia and Reperfusion: The Role of Oxidative Stress. Oxid Med Cell Longev. 2018;2018:5979721 pubmed publisher
	Chen Y, Aon M, Hsu Y, Soane L, Teng X, McCaffery J, et al. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol. 2011;195:263-76 pubmed publisher
	Birks S, Danquah J, King L, Vlasak R, Gorecki D, Pilkington G. Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma. Neuro Oncol. 2011;13:950-60 pubmed publisher
	Andoniou C, Andrews D, Manzur M, Ricciardi Castagnoli P, Degli Esposti M. A novel checkpoint in the Bcl-2-regulated apoptotic pathway revealed by murine cytomegalovirus infection of dendritic cells. J Cell Biol. 2004;166:827-37 pubmed
	Risso de Faverney C, Orsini N, de Sousa G, Rahmani R. Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress. Aquat Toxicol. 2004;69:247-58 pubmed
	Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004;279:1281-90 pubmed
	Wilkinson B, Elam J, Fadool D, Hyson R. Afferent regulation of cytochrome-c and active caspase-9 in the avian cochlear nucleus. Neuroscience. 2003;120:1071-9 pubmed
	Love D, Kochan J, Cathey R, Shin S, Hanover J, Kochran J. Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase. J Cell Sci. 2003;116:647-54 pubmed
	Hetz C, Bono M, Barros L, Lagos R. Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines. Proc Natl Acad Sci U S A. 2002;99:2696-701 pubmed
	Yu F, Finley R, Raz A, Kim H. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation. J Biol Chem. 2002;277:15819-27 pubmed

product information

Product Type :

Antibody

Product Name :

Cytochrome C Monoclonal Antibody (7H8.2C12)

Catalog # :

33-8500

Quantity :

200 µg

Price :

US 405.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Drosophila, Equine, Human, Mouse, Rabbit, Rat, Xenopus laevis

Applications :

Western Blot: 1:1,000

Species :

Drosophila, Equine, Human, Mouse, Rabbit, Rat, Xenopus laevis

Clone :

7H8.2C12

Isotype :

IgG2b, kappa

Storage :

-20°C

Description :

Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.

Immunogen :

Equine Cytochrome c.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

CG17903; CG17903-PA; CG17903-PB; CRF; CYC; CYC2; Cycs; CYCSA; Cyct-c-p; Cyt c; cyt c-p; cyt.c; CytC; Cyt-c; CYTC2; Cyt-c2; CytC-2; cyt-c-p; cytC-p; Cyt-c-p-PA; Cyt-c-p-PB; Cytochrome c; cytochrome c DC4; Cytochrome c proximal; Cytochrome C, expressed in somatic tissues; cytochrome c, somatic; Cytochrome c-2; cytochrome c-like; cytochrome c-like protein; Cytochrome c-proximal; cytochrome-c-p; Cytochrome-c-proximal; DC4; dCyt.C-p; DMc01; Dmel CG17903; Dmel_CG17903; hc1; HCS; l(2)k13905; lethal (2) k13905; LOC100341175; LOC100357840; MGC128356 protein; pDMc01; RH17228p; THC4

more info or order :

Invitrogen product webpage