product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MSH2 Monoclonal Antibody (FE11)
catalog :
33-7900
quantity :
50 ug
price :
US 520.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
FE11
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
more info or order :
citations: 45
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig s2a
Mandal R, Samstein R, Lee K, Havel J, Wang H, Krishna C, et al. Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response. Science. 2019;364:485-491 pubmed publisher
  • western blot; human; loading ...; fig 1s1c
Pech M, Fong L, Villalta J, Chan L, Kharbanda S, O Brien J, et al. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. elife. 2019;8: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; tbl 2
Massalou D, Benizri E, Chevallier A, Duranton Tanneur V, Pedeutour F, Benchimol D, et al. Peritoneal carcinomatosis of colorectal cancer: novel clinical and molecular outcomes. Am J Surg. 2017;213:377-387 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig s1
Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Kim K, Wen X, Yang H, Kim W, Kang G. Prognostic Implication of M2 Macrophages Are Determined by the Proportional Balance of Tumor Associated Macrophages and Tumor Infiltrating Lymphocytes in Microsatellite-Unstable Gastric Carcinoma. PLoS ONE. 2015;10:e0144192 pubmed publisher
  • immunohistochemistry - paraffin section; human
Shin S, Yu E, Lee Y, Song Y, Seong M, Park S. Characteristics of hereditary nonpolyposis colorectal cancer patients with double primary cancers in endometrium and colorectum. Obstet Gynecol Sci. 2015;58:112-6 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...
Boulagnon C, Dudez O, Beaudoux O, Dalstein V, Kianmanesh R, Bouché O, et al. BRAFV600E Gene Mutation in Colonic Adenocarcinomas. Immunohistochemical Detection Using Tissue Microarray and Clinicopathologic Characteristics: An 86 Case Series. Appl Immunohistochem Mol Morphol. 2016;24:88-96 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Lee J, Cragun D, Thompson Z, Coppola D, Nicosia S, Akbari M, et al. Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer. Genet Test Mol Biomarkers. 2014;18:229-35 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 1
Dadone B, Ambrosetti D, Carpentier X, Duranton Tanneur V, Burel Vandenbos F, Amiel J, et al. A renal metanephric adenoma showing both a 2p16e24 deletion and BRAF V600E mutation: a synergistic role for a tumor suppressor gene on chromosome 2p and BRAF activation?. Cancer Genet. 2013;206:347-52 pubmed
  • immunohistochemistry - paraffin section; human; fig 2
Boulagnon C, Jazeron J, Diaz Cives A, Ehrhard F, Bouche O, Diebold M. Filiform polyposis: A benign entity? Case report and literature review. Pathol Res Pract. 2014;210:189-93 pubmed publisher
  • immunohistochemistry; human; 1:250; tbl 1
Li M, Zhang Q, Liu L, Lu W, Wei H, Li R, et al. Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations. PLoS ONE. 2013;8:e78500 pubmed publisher
  • western blot; human; fig 7
Campos Vega R, García Gasca T, Guevara González R, Ramos Gomez M, Oomah B, Loarca Pina G. Human gut flora-fermented nondigestible fraction from cooked bean ( Phaseolus vulgaris L.) modifies protein expression associated with apoptosis, cell cycle arrest, and proliferation in human adenocarcinoma colon cancer cells. J Agric Food Chem. 2012;60:12443-50 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; tbl 2
Coppola D, Nicosia S, Doty A, Sellers T, Lee J, Fulp J, et al. Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. Anticancer Res. 2012;32:4963-9 pubmed
  • immunohistochemistry - paraffin section; human; fig 3
Couronné L, Ruminy P, Waultier Rascalou A, Rainville V, Cornic M, Picquenot J, et al. Mutation mismatch repair gene deletions in diffuse large B-cell lymphoma. Leuk Lymphoma. 2013;54:1079-86 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 3
Helal T, Fadel M, El Thobbani A, El Sarhi A. Immunoexpression of p53 and hMSH2 in oral squamous cell carcinoma and oral dysplastic lesions in Yemen: relationship to oral risk habits and prognostic factors. Oral Oncol. 2012;48:120-4 pubmed publisher
  • immunohistochemistry - paraffin section; human
Gatalica Z, Lilleberg S, Monzon F, Koul M, Bridge J, Knezetic J, et al. Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes. Hum Pathol. 2011;42:1979-88 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 4
Martin S, McCabe N, Mullarkey M, Cummins R, Burgess D, Nakabeppu Y, et al. DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell. 2010;17:235-48 pubmed publisher
  • immunohistochemistry - paraffin section; human
Cossio S, Koehler Santos P, Pessini S, Mónego H, Edelweiss M, Meurer L, et al. Clinical and histomolecular endometrial tumor characterization of patients at-risk for Lynch syndrome in South of Brazil. Fam Cancer. 2010;9:131-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Mei M, Deng D, Liu T, Sang X, Lu X, Xiang H, et al. Clinical implications of microsatellite instability and MLH1 gene inactivation in sporadic insulinomas. J Clin Endocrinol Metab. 2009;94:3448-57 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
Tobón Arroyave S, Flórez Moreno G, Jaramillo Cárdenas J, Arango Uribe J, Isaza Guzmán D, Rendón Henao J. Expression of hMLH1 and hMSH2 proteins in pleomorphic adenoma of minor salivary glands: relationship with clinical and histologic findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:227-36 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:150
Arabi H, Guan H, Kumar S, Cote M, Bandyopadhyay S, Bryant C, et al. Impact of microsatellite instability (MSI) on survival in high grade endometrial carcinoma. Gynecol Oncol. 2009;113:153-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Permuth Wey J, Boulware D, Valkov N, Livingston S, Nicosia S, Lee J, et al. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:28-34 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Bendardaf R, Lamlum H, Ristamaki R, Syrjanen K, Pyrhonen S. Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. Oncol Rep. 2008;20:999-1004 pubmed
  • immunohistochemistry - paraffin section; human; 1:140
Mylona E, Zarogiannos A, Nomikos A, Giannopoulou I, Nikolaou I, Zervas A, et al. Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder. APMIS. 2008;116:59-65 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; fig 1
Li M, Liu L, Wang Z, Wang L, Liu Z, Xu G, et al. Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Oncol Rep. 2008;19:401-6 pubmed
  • immunohistochemistry - paraffin section; human
Yoon S, Ku J, Shin Y, Kim K, Choi J, Jang E, et al. Hereditary nonpolyposis colorectal cancer in endometrial cancer patients. Int J Cancer. 2008;122:1077-81 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
Bendardaf R, Lamlum H, Ristamaki R, Korkeila E, Syrjanen K, Pyrhonen S. Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. Acta Oncol. 2008;47:1046-53 pubmed
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
Taylor N, Zighelboim I, Huettner P, Powell M, Gibb R, Rader J, et al. DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis. Mod Pathol. 2006;19:1333-8 pubmed
  • immunohistochemistry - paraffin section; human
Edelmann J, Richter K, Hanel C, Hering S, Horn L. X chromosomal and autosomal loss of heterozygosity and microsatellite instability in human cervical carcinoma. Int J Gynecol Cancer. 2006;16:1248-53 pubmed
  • immunohistochemistry; human; 1:100
Kerber R, Neklason D, Samowitz W, Burt R. Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database. Fam Cancer. 2005;4:239-44 pubmed
  • immunohistochemistry - paraffin section; human
Chen Z, Ritter J, Wang H. Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestines. Am J Surg Pathol. 2005;29:890-6 pubmed
  • immunohistochemistry - paraffin section; human
Ricciardiello L, Ceccarelli C, Angiolini G, Pariali M, Chieco P, Paterini P, et al. High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. Clin Cancer Res. 2005;11:4234-40 pubmed
  • immunohistochemistry; human; 1:20
Aust D, Haase M, Dobryden L, Markwarth A, Löhrs U, Wittekind C, et al. Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma. Int J Cancer. 2005;115:673-7 pubmed
  • immunohistochemistry - paraffin section; human; 1:400
Charara M, Edmonston T, Burkholder S, Walters R, Anne P, Mitchell E, et al. Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. Anticancer Res. 2004;24:3161-7 pubmed
  • immunohistochemistry - paraffin section; human; 1:400
Boman B, Walters R, Fields J, Kovatich A, Zhang T, Isenberg G, et al. Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell population. Am J Pathol. 2004;165:1489-98 pubmed
  • immunohistochemistry - paraffin section; human; 1:400; fig 4
Buttin B, Powell M, Mutch D, Rader J, Herzog T, Gibb R, et al. Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation. Clin Cancer Res. 2004;10:481-90 pubmed
Ying B, Tang T, Zhang L, Xiong J, Zhao K, Li J, et al. Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review. Oncol Lett. 2024;27:56 pubmed publisher
Xu P, Sun D, Gao Y, Jiang Y, Zhong M, Zhao G, et al. Germline mutations in a DNA repair pathway are associated with familial colorectal cancer. JCI Insight. 2021;6: pubmed publisher
Tsuboi A, Urabe Y, Oka S, Sumioka A, Iio S, Yuge R, et al. Genomic analysis for the prediction of prognosis in small-bowel cancer. PLoS ONE. 2021;16:e0241454 pubmed publisher
Rikitake M, Fujikane R, Obayashi Y, Oka K, Ozaki M, Hidaka M. MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O6 -methylguanine. Genes Cells. 2020;25:175-186 pubmed publisher
Takeishi Y, Fujikane R, Rikitake M, Obayashi Y, Sekiguchi M, Hidaka M. SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLα to MutSα on damaged chromatin induces apoptosis in human cells. J Biol Chem. 2019;: pubmed publisher
Markowska A, Szarszewska M, Zurawski J, Sajdak S, Knapp P, Gryboś A, et al. Studies on selected molecular factors in endometrial cancers. Adv Clin Exp Med. 2018;27:1417-1424 pubmed publisher
Hosoda K, Yashima K, Tamoto A, Yamamoto S, Kawata S, Ikebuchi Y, et al. Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. Oncol Lett. 2017;14:737-742 pubmed publisher
Al Temaimi R, Jacob S, Al Ali W, Thomas D, Al Mulla F. Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. J Histochem Cytochem. 2013;61:627-38 pubmed publisher
Kenyon J, Fu P, Lingas K, Thomas E, Saurastri A, Santos Guasch G, et al. Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 2012;120:3229-36 pubmed publisher
product information
Product Type :
Antibody
Product Name :
MSH2 Monoclonal Antibody (FE11)
Catalog # :
33-7900
Quantity :
50 ug
Price :
US 520.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 2-3 ug/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL
Species :
Human, Mouse, Rat
Clone :
FE11
Isotype :
IgG1, kappa
Storage :
-20 C
Description :
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Immunogen :
C-terminal fragment of the human MSH2 protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2-3 ug/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL
Aliases :
AI788990; COCA1; DNA mismatch repair protein MSH2; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; mismatch repair ATPase MSH2; mismatch repair protein; MSH2; Msh2p; mutS homolog 2; mutS homolog 2 (E. coli); mutS homolog 2, colon cancer, nonpolyposis type 1; mutS protein homolog 2; O0935; PMS5; YOL090W
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA