Bax Monoclonal Antibody (6A7) | Invitrogen 33-6600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bax Monoclonal Antibody (6A7)

catalog :

33-6600

quantity :

100 µg

price :

US 398.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6A7

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; rat; fig 3b	Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCÎ´-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44:760-770 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; fig 2A	Takei H, Buckleair L, Powell S. Immunohistochemical expression of apoptosis regulating proteins and sex hormone receptors in meningiomas. Neuropathology. 2008;28:62-8 pubmed
western blot; human	Kim B, Chung H. Hypoxia/reoxygenation induces apoptosis through a ROS-mediated caspase-8/Bid/Bax pathway in human lymphocytes. Biochem Biophys Res Commun. 2007;363:745-50 pubmed
immunohistochemistry; rat; 1:100; tbl 1	Tan Z, Sankar R, Tu W, Shin D, Liu H, Wasterlain C, et al. Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. Brain Res. 2002;929:129-38 pubmed
	Dogan G, Karaca O. Evaluation of Neuroprotective Effect of Sevoflurane in Acute Traumatic Brain Injury: An Experimental Study in Rats. Turk Neurosurg. 2020;30:237-243 pubmed publisher
	Dogan G, Karaca O. N-methyl-D-aspartate Receptor Antagonists may Ameliorate Spinal Cord Injury by Inhibiting Oxidative Stress: An Experimental Study in Rats. Turk Neurosurg. 2020;30:60-68 pubmed publisher
	Wang Y, Lv J, Cheng Y, DU J, Chen D, Li C, et al. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PLoS ONE. 2015;10:e0124812 pubmed publisher
	Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013;19:1478-88 pubmed publisher
	Fischer S, Vier J, Kirschnek S, Klos A, Hess S, Ying S, et al. Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J Exp Med. 2004;200:905-16 pubmed
	Yaglom J, Ekhterae D, Gabai V, Sherman M. Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC. J Biol Chem. 2003;278:50483-96 pubmed

product information

Product Type :

Antibody

Product Name :

Bax Monoclonal Antibody (6A7)

Catalog # :

33-6600

Quantity :

100 µg

Price :

US 398.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Mouse, Rat

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse, Rat

Clone :

6A7

Isotype :

IgG1

Storage :

-20°C

Description :

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

Immunogen :

Synthetic peptide corresponding to a sequence at the N-terminal of the protein that is common to mouse and rat.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52

more info or order :

Invitrogen product webpage