Osteocalcin Monoclonal Antibody (OCG-3) | Invitrogen 33-5700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Osteocalcin Monoclonal Antibody (OCG-3)

catalog :

33-5700

quantity :

100µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OCG-3

reactivity :

human, cow

application :

western blot, ELISA, immunocytochemistry

citations: 1

Published Application/Species/Dilution	Reference
immunocytochemistry; human	Jager M, Thorey F, Westhoff B, Wild A, Krauspe R. In vitro osteogenic differentiation is affected in Wiedemann-Rautenstrauch-Syndrome (WRS). In Vivo. 2005;19:831-6 pubmed

product information

Product Type :

Antibody

Product Name :

Osteocalcin Monoclonal Antibody (OCG-3)

Catalog # :

33-5700

Quantity :

100µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Ammonium sulfate precipitation, Ion-exchange chromatography

Host :

Mouse

Reactivity :

Bovine, Human

Applications :

ELISA: 1:1000, Western Blot: 2-10µg/ml

Species :

Bovine, Human

Clone :

OCG-3

Isotype :

IgG3

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Prior to the formation of calcified bone, non+collagenous proteins form in the extracellular bone matrix. gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitute 1-2% of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.

Immunogen :

Bovine Osteocalcin

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 1:1000, Western Blot: 2-10µg/ml

Aliases :

BGLAP, BGP, Gamma-carboxyglutamic acid-containing protein, OC

PubMed References :

16097434