E-cadherin Monoclonal Antibody (4A2C7) | Invitrogen 33-4000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

E-cadherin Monoclonal Antibody (4A2C7)

catalog :

33-4000

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A2C7

reactivity :

Clostridioides difficile, black ferret, Japanese crane, human, mouse, rat, dogs, pigs , rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 233

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig s3b, s4 immunohistochemistry; human; 1:100; fig 4b	Koide T, Koyanagi Aoi M, Uehara K, Kakeji Y, Aoi T. CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells. iScience. 2022;25:104314 pubmed publisher
immunohistochemistry - frozen section; human; loading ...; fig 2	Hering H, Zoschke C, Kühn M, Gadicherla A, Weindl G, Luch A, et al. TatS: a novel in vitro tattooed human skin model for improved pigment toxicology research. Arch Toxicol. 2020;94:2423-2434 pubmed publisher
immunohistochemistry; human; 1:50; loading ...; fig s t3	Christgen M, Bartels S, van Luttikhuizen J, Bublitz J, Rieger L, Christgen H, et al. E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements. Mod Pathol. 2020;33:2483-2498 pubmed publisher
immunohistochemistry; human; 1:200; loading ...; fig 1f	Kim Y, You H, Park S, Kim M, Chae H, Park J, et al. A Mutation in ZNF143 as a Novel Candidate Gene for Endothelial Corneal Dystrophy. J Clin Med. 2019;8: pubmed publisher
western blot; human; 1:500; loading ...; fig 4e	Hayward A, Aird E, Gordon W. A toolkit for studying cell surface shedding of diverse transmembrane receptors. elife. 2019;8: pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 2e	Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
immunohistochemistry; human; tbl 1	Morandi L, Righi A, Maletta F, Rucci P, Pagni F, Gallo M, et al. Somatic mutation profiling of hobnail variant of papillary thyroid carcinoma. Endocr Relat Cancer. 2017;24:107-117 pubmed publisher
western blot; human; 1:500; loading ...; fig 4d	Zangari J, Ilie M, Rouaud F, Signetti L, Ohanna M, Didier R, et al. Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition. Nucleic Acids Res. 2017;45:4131-4141 pubmed publisher
western blot; human; fig 1a	Runge T, Shaheen N, Djukic Z, Hallquist S, Orlando R. Cleavage of E-Cadherin Contributes to Defective Barrier Function in Neosquamous Epithelium. Dig Dis Sci. 2016;61:3169-3175 pubmed
western blot; human; 1:500; fig s8	Chung I, Reichelt M, Shao L, Akita R, Koeppen H, Rangell L, et al. High cell-surface density of HER2 deforms cell membranes. Nat Commun. 2016;7:12742 pubmed publisher
immunohistochemistry - paraffin section; human; 1:80; fig 3	Cardoso J, Mesquita M, Dias Pereira A, Bettencourt Dias M, Chaves P, Pereira Leal J. CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression. PLoS ONE. 2016;11:e0161967 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; tbl 3	Liu S, Barry E, Baron J, Rutherford R, Seabrook M, Bostick R. Effects of supplemental calcium and vitamin D on the APC/Î²-catenin pathway in the normal colorectal mucosa of colorectal adenoma patients. Mol Carcinog. 2017;56:412-424 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 2	Piton N, Wason J, Colasse É, Cornic M, Lemoine F, Le Pessot F, et al. Endoplasmic reticulum stress, unfolded protein response and development of colon adenocarcinoma. Virchows Arch. 2016;469:145-54 pubmed publisher
immunohistochemistry - paraffin section; human; 1:800; loading ...; tbl 1	Chung M, Lee J, Kim S, Suh Y, Choi H. Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer. Medicine (Baltimore). 2016;95:e3689 pubmed publisher
immunohistochemistry - paraffin section; dogs; 1:100; loading ...; fig 1a	Payan Carreira R, Pires M, Santos C, Holst B, Colaco J, Rodriguez Martinez H. Immunolocalization of E-cadherin and ?-catenin in the cyclic and early pregnant canine endometrium. Theriogenology. 2016;86:1092-1101 pubmed publisher
immunohistochemistry; human; loading ...	Song M, Park Y, Song H, Park S, Ahn J, Choi K, et al. Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study. Gut Liver. 2016;10:731-8 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 1c	Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, et al. SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer. Cancer Sci. 2016;107:619-28 pubmed publisher
western blot; human; 1:500; fig 3	Patkee W, Carr G, Baker E, Baines D, Garnett J. Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth. J Cell Mol Med. 2016;20:758-64 pubmed publisher
immunohistochemistry; human; 1:2; fig 1	Terashita K, Chuma M, Hatanaka Y, Hatanaka K, Mitsuhashi T, Yokoo H, et al. ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma. J Clin Pathol. 2016;69:593-9 pubmed publisher
immunocytochemistry; dogs; 10 ug/ml; fig 4	Xu Y, Ma L, Norton M, Stuart C, Zhao Z, Toibero D, et al. Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs. Placenta. 2015;36:1370-7 pubmed publisher
immunohistochemistry - paraffin section; mouse chromatin immunoprecipitation; mouse	Gamba C, Rodrigues M, Gomes D, Estrela Lima A, Ferreira E, Cassali G. The Relationship Between E-Cadherin and its Transcriptional Repressors in Spontaneously Arising Canine Invasive Micropapillary Mammary Carcinoma. J Comp Pathol. 2015;153:256-65 pubmed publisher
western blot; human	Mori S, Kodaira M, Ito A, Okazaki M, Kawaguchi N, Hamada Y, et al. Enhanced Expression of Integrin Î±vÎ²3 Induced by TGF-Î² Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-Î²-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. PLoS ONE. 2015;10:e0137486 pubmed publisher
immunohistochemistry; mouse; 1:100; fig 2	Baruch K, Rosenzweig N, Kertser A, Deczkowska A, Sharif A, Spinrad A, et al. Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology. Nat Commun. 2015;6:7967 pubmed publisher
immunohistochemistry - paraffin section; human	Ozgüven B, Tuncel D, Polat N, Sakiz D, Kabukcuoglu F, Köksal H, et al. Solid-pseudopapillary neoplasm of the pancreas: Clinicopathologic and immunohistochemical analysis of nine cases. Indian J Pathol Microbiol. 2015;58:292-5 pubmed publisher
immunohistochemistry - paraffin section; human; tbl 2	Bartosch C, Mendes N, Rios E, Rodrigues M, Eloy C, Reis C, et al. Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation. Pathol Res Pract. 2015;211:588-95 pubmed publisher
immunocytochemistry; mouse; fig 7	Jackson B, Ivanova I, Dagnino L. An ELMO2-RhoG-ILK network modulates microtubule dynamics. Mol Biol Cell. 2015;26:2712-25 pubmed publisher
immunohistochemistry - paraffin section; dogs; 1:25	Mandara M, Reginato A, Foiani G, Baroni M, Poli F, Gasparinetti N, et al. Papillary meningioma in the dog: A clinicopathological case series study. Res Vet Sci. 2015;100:213-9 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Kim Y, Jin D, Lee B, Cho E, Han J, Shim Y, et al. RARÎ²2 hypermethylation is associated with poor recurrence-free survival in never-smokers with adenocarcinoma of the lung. Clin Epigenetics. 2015;7:32 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Fang J, Zhou H, Zhang C, Shang L, Zhang L, Xu J, et al. A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an epithelial-mesenchymal transition-independent manner. Hepatology. 2015;62:452-65 pubmed publisher
immunohistochemistry; human; 1:1200; fig 2	Kang Y, Cho C, Kwon S. Microcystic stromal tumor of the ovary with mutation in exon 3 of Î²-catenin: a case report. Int J Gynecol Pathol. 2015;34:121-5 pubmed publisher
immunohistochemistry - paraffin section; black ferret; 1:100; tbl 3	Yui T, Ohmachi T, Matsuda K, Okamoto M, Taniyama H. Histochemical and immunohistochemical characterization of chordoma in ferrets. J Vet Med Sci. 2015;77:467-73 pubmed publisher
immunohistochemistry - paraffin section; human	Kang W, Lee J, Oh S, Lee S, Jung C. Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse. BMC Gastroenterol. 2015;15:2 pubmed publisher
immunohistochemistry; human	Figueira A, Gomes C, de Oliveira J, Vilhena H, Carvalheira J, de Matos A, et al. Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas. BMC Vet Res. 2014;10:270 pubmed publisher
immunohistochemistry - frozen section; human	Raiko L, Leinonen P, HÃ¤gg P, Peltonen J, Oikarinen A, Peltonen S. Tight junctions in Hailey-Hailey and Darier's diseases. Dermatol Reports. 2009;1:e1 pubmed publisher
western blot; mouse	Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
immunohistochemistry - paraffin section; human; 1:800	Preda V, Larkin S, Karavitaki N, Ansorge O, Grossman A. The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis. Endocr Pathol. 2015;26:1-8 pubmed publisher
western blot; rat; 1:1000	Altshuler A, Lamadrid I, Li D, Ma S, Kurre L, Schmid Schonbein G, et al. Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition. PLoS ONE. 2014;9:e96655 pubmed publisher
immunohistochemistry - paraffin section; human; 1:25	Ohgami R, Chisholm K, Ma L, Arber D. E-cadherin is a specific marker for erythroid differentiation and has utility, in combination with CD117 and CD34, for enumerating myeloblasts in hematopoietic neoplasms. Am J Clin Pathol. 2014;141:656-64 pubmed publisher
immunohistochemistry - paraffin section; dogs; 1:50	Rodrigues M, Rema A, Gartner M, Laufer Amorim R. Role of adhesion molecules and proliferation hyperplasic, pre neoplastic and neoplastic lesions in canine prostate. Pak J Biol Sci. 2013;16:1324-9 pubmed
immunohistochemistry - paraffin section; human immunocytochemistry; human western blot; human; 1:1000	Yu Y, Xiao C, Tan L, Wang Q, Li X, Feng Y. Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-? signalling. Br J Cancer. 2014;110:724-32 pubmed publisher
immunohistochemistry; human; 1:400	Kim S, Kim M, Kim M, Kim S, Choi J, Yu E, et al. Pleomorphic solid pseudopapillary neoplasm of the pancreas: degenerative change rather than high-grade malignant potential. Hum Pathol. 2014;45:166-74 pubmed publisher
western blot; rat; 1:1000	Altshuler A, Richter M, Modestino A, Penn A, Heller M, Schmid Schonbein G. Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. Physiol Rep. 2013;1:e00109 pubmed publisher
immunohistochemistry - paraffin section; pigs ; fig 1	Basso K, Gomes F, Bracarense A. Deoxynivanelol and fumonisin, alone or in combination, induce changes on intestinal junction complexes and in E-cadherin expression. Toxins (Basel). 2013;5:2341-52 pubmed publisher
immunocytochemistry; Clostridioides difficile; fig 5	Kasendra M, Barrile R, Leuzzi R, Soriani M. Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium. J Infect Dis. 2014;209:1095-104 pubmed publisher
immunocytochemistry; dogs; fig 3 western blot; dogs; fig 7	Shiobara T, Usui T, Han J, Isoda H, Nagumo Y. The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin. PLoS ONE. 2013;8:e79954 pubmed publisher
immunohistochemistry; human	Yu L, Cheng H, Yang S. Clinicopathological and extensive immunohistochemical study of a type II pleuropulmonary blastoma. Fetal Pediatr Pathol. 2014;33:1-8 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Gu M, Choi J. Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma. J Clin Pathol. 2014;67:229-34 pubmed publisher
immunohistochemistry; dogs	Yasuno K, Nishiyama S, Kobayashi R, Yoshimura H, Takahashi K, Omachi T, et al. Proliferative lesions of intra-epidermal cytokeratin CAM5.2-positive cells in canine nipples. J Comp Pathol. 2014;150:18-26 pubmed publisher
immunohistochemistry; mouse; fig 1	Karch I, Schipper E, Christgen H, Kreipe H, Lehmann U, Christgen M. Is upregulation of BCL2 a determinant of tumor development driven by inactivation of CDH1/E-cadherin?. PLoS ONE. 2013;8:e73062 pubmed publisher
immunohistochemistry; pigs ; fig 2	Bracarense A, Yamasaki L, Silva E, Oliveira R, Alfieri A. Helicobacter spp. infection induces changes in epithelial proliferation and E-cadherin expression in the gastric mucosa of pigs. J Comp Pathol. 2013;149:402-9 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200; fig 1 immunohistochemistry - paraffin section; human; 1:200; fig 1	Vlug E, van de Ven R, Vermeulen J, Bult P, van Diest P, Derksen P. Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer. Cell Oncol (Dordr). 2013;36:375-84 pubmed publisher
western blot; mouse; fig 4	Chang C, Yang X, Pursell B, Mercurio A. Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ?4. Mol Cell Biol. 2013;33:3795-804 pubmed publisher
western blot; human; 1:1000	Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, et al. p38? mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes. Arch Dermatol Res. 2014;306:131-41 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; tbl 1	Bubis G, Hilly O, Bubis R, Halpern M, Schwartz A, Koren R, et al. A new Ki-67 / E-cadherin cocktail reduces inter-observer variation of the calculated proliferative index. Pathol Oncol Res. 2013;19:875-9 pubmed publisher
immunohistochemistry; human; 1:200; fig 1	Schackmann R, Klarenbeek S, Vlug E, Stelloo S, van Amersfoort M, Tenhagen M, et al. Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling. Cancer Res. 2013;73:4937-49 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Pinho S, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhaes A, et al. E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V. Biochim Biophys Acta. 2013;1830:2690-700 pubmed
immunohistochemistry - paraffin section; mouse; 1:50; fig 2	Vasconcelos Nóbrega C, Costa C, Vala H, Colaco A, Santos L, Lopes C, et al. E-cadherin and ?-catenin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice. Urol Int. 2013;91:462-6 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Griffin J, Wriston C, Peters M, Lehman J. Decreased expression of intercellular adhesion molecules in acantholytic squamous cell carcinoma compared with invasive well-differentiated squamous cell carcinoma of the skin. Am J Clin Pathol. 2013;139:442-7 pubmed publisher
immunohistochemistry - paraffin section; Japanese crane; fig 4	Sakaguchi K, Iima H, Matsuda K, Okamoto M, Hirayama K, Ikoma S, et al. Intestinal undifferentiated carcinoma in a red-crowned crane (Grus japonensis). J Vet Med Sci. 2013;75:827-30 pubmed
immunohistochemistry - paraffin section; human; 1:100; fig 1	Taskin S, Dunder I, Erol E, Taşkin E, Kiremitci S, Oztuna D, et al. Roles of E-cadherin and cyclooxygenase enzymes in predicting different survival patterns of optimally cytoreduced serous ovarian cancer patients. Asian Pac J Cancer Prev. 2012;13:5715-9 pubmed
immunohistochemistry - frozen section; human; 1:200; fig 5	Angelucci C, Maulucci G, Lama G, Proietti G, Colabianchi A, Papi M, et al. Epithelial-stromal interactions in human breast cancer: effects on adhesion, plasma membrane fluidity and migration speed and directness. PLoS ONE. 2012;7:e50804 pubmed publisher
western blot; human; fig 3	Langer M, Duggan E, Booth J, Patel V, Zander R, Silasi Mansat R, et al. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012;80:4374-87 pubmed publisher
immunohistochemistry; human; 1:50; fig 2	Ahearn T, Shaukat A, Flanders W, Rutherford R, Bostick R. A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC/?-catenin pathway in the normal mucosa of colorectal adenoma patients. Cancer Prev Res (Phila). 2012;5:1247-56 pubmed publisher
immunohistochemistry; mouse; 1:150	Gil da Costa R, Oliveira P, Bastos M, Lopes C, Lopes C. Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact ?-catenin and E-cadherin expression. Environ Toxicol. 2014;29:763-9 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400; fig 1	Tsang J, Mendoza P, Putti T, Karim R, Scolyer R, Lee C, et al. E-cadherin expression in the epithelial components of mammary phyllodes tumors. Hum Pathol. 2012;43:2117-23 pubmed publisher
immunohistochemistry; human; 1:200; fig 2	Vermeulen J, van de Ven R, Ercan C, van der Groep P, van der Wall E, Bult P, et al. Nuclear Kaiso expression is associated with high grade and triple-negative invasive breast cancer. PLoS ONE. 2012;7:e37864 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Tobin N, Lundgren K, Conway C, Anagnostaki L, Costello S, Landberg G. Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information. Hum Pathol. 2012;43:2053-61 pubmed publisher
immunocytochemistry; human; fig 6	Iacopino F, Angelucci C, Sica G. Interactions between normal human fibroblasts and human prostate cancer cells in a co-culture system. Anticancer Res. 2012;32:1579-88 pubmed
immunohistochemistry - paraffin section; human; 1:50; tbl 2	Ahearn T, Shaukat A, Flanders W, Seabrook M, Bostick R. Markers of the APC/?-catenin signaling pathway as potential treatable, preneoplastic biomarkers of risk for colorectal neoplasms. Cancer Epidemiol Biomarkers Prev. 2012;21:969-79 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; fig 1	Vincent Salomon A, Hajage D, Rouquette A, Cédenot A, Gruel N, Alran S, et al. High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients. Breast. 2012;21:380-3 pubmed publisher
immunohistochemistry - paraffin section; human; fig 3	Stoyianni A, Goussia A, Pentheroudakis G, Siozopoulou V, Ioachim E, Krikelis D, et al. Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility. Anticancer Res. 2012;32:1273-81 pubmed
immunohistochemistry - paraffin section; human; 1:25; fig 1	Chang D, Pai R, Rybicki L, DiMaio M, Limaye M, Jayachandran P, et al. Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features. Mod Pathol. 2012;25:1128-39 pubmed publisher
immunohistochemistry; human; fig 3	Lisch W, Bron A, Munier F, Schorderet D, Tiab L, Lange C, et al. Franceschetti hereditary recurrent corneal erosion. Am J Ophthalmol. 2012;153:1073-81.e4 pubmed publisher
immunocytochemistry; dogs; fig 1	Dukes J, Whitley P, Chalmers A. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE. 2012;7:e28659 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Palka Bayard de Volo C, Alfonsi M, Gatta V, Novelli A, Bernardini L, Fantasia D, et al. 16q22.1 microdeletion detected by array-CGH in a family with mental retardation and lobular breast cancer. Gene. 2012;498:328-31 pubmed publisher
immunohistochemistry; human; fig 2	Zhang J, Liang Z, Gao J, Luo Y, Liu T. Pulmonary adenocarcinoma with a micropapillary pattern: a clinicopathological, immunophenotypic and molecular analysis. Histopathology. 2011;59:1204-14 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Zhi W, Xue B, Wang L, Xiao N, He Q, Wang Y, et al. The MLH1 2101C>A (Q701K) variant increases the risk of gastric cancer in Chinese males. BMC Gastroenterol. 2011;11:133 pubmed publisher
immunocytochemistry; mouse; fig 5	Schneider D, Wu M, Le T, Cho S, Brenner M, Blackburn M, et al. Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-? production and epithelial to mesenchymal transition. FASEB J. 2012;26:503-12 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Giricz O, Reynolds P, Ramnauth A, Liu C, Wang T, Stead L, et al. Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. J Pathol. 2012;226:108-19 pubmed publisher
immunohistochemistry - paraffin section; pigs ; 1:50; fig 5	Bracarense A, Lucioli J, Grenier B, Drociunas Pacheco G, Moll W, Schatzmayr G, et al. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br J Nutr. 2012;107:1776-86 pubmed publisher
immunohistochemistry - paraffin section; human; 1:500; fig 7 immunohistochemistry - paraffin section; mouse; 1:500; fig 7	Sin S, Bonin F, Petit V, Meseure D, Lallemand F, Bieche I, et al. Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. J Natl Cancer Inst. 2011;103:1323-37 pubmed publisher
immunohistochemistry - paraffin section; human	Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, et al. Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12. Am J Pathol. 2011;179:1471-82 pubmed publisher
immunocytochemistry; dogs; 1:25; fig 1	Dukes J, Fish L, Richardson J, Blaikley E, Burns S, Caunt C, et al. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Mol Biol Cell. 2011;22:3192-205 pubmed publisher
immunohistochemistry; mouse; fig 2	Essbauer S, Krautkrämer E, Herzog S, Pfeffer M. A new permanent cell line derived from the bank vole (Myodes glareolus) as cell culture model for zoonotic viruses. Virol J. 2011;8:339 pubmed publisher
immunohistochemistry; mouse; fig 3	Russell S, Lechner M, Gong L, Megiel C, Liebertz D, Masood R, et al. USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011;47:810-7 pubmed publisher
immunohistochemistry; mouse; fig s3	Goel H, Bae D, Pursell B, Gouvin L, Lu S, Mercurio A. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development. 2011;138:2969-76 pubmed publisher
immunohistochemistry - paraffin section; human; fig 2	Betge J, Pollheimer M, Schlemmer A, Hoefler G, Langner C. Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis. Oncol Rep. 2011;26:567-75 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Ding T, Xu J, Zhang Y, Guo R, Wu W, Zhang S, et al. Endothelium-coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection. Cancer. 2011;117:4878-89 pubmed publisher
immunohistochemistry; human; fig 4	Jovov B, Que J, Tobey N, Djukic Z, Hogan B, Orlando R. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol. 2011;106:1039-47 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Ferreira E, Gobbi H, Saraiva B, Cassali G. Histological and immunohistochemical identification of atypical ductal mammary hyperplasia as a preneoplastic marker in dogs. Vet Pathol. 2012;49:322-9 pubmed publisher
immunohistochemistry - paraffin section; rat; 1:120; fig 7	Chen M, Peyrin Biroulet L, George A, Coste F, Bressenot A, Bossenmeyer Pourié C, et al. Methyl deficient diet aggravates experimental colitis in rats. J Cell Mol Med. 2011;15:2486-97 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Lewis Tuffin L, Rodriguez F, Giannini C, Scheithauer B, Necela B, Sarkaria J, et al. Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. PLoS ONE. 2010;5:e13665 pubmed publisher
immunohistochemistry; human; 1:50; fig 6	da Cunha C, Oliveira C, Wen X, Gomes B, Sousa S, Suriano G, et al. De novo expression of CD44 variants in sporadic and hereditary gastric cancer. Lab Invest. 2010;90:1604-14 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Yong Jiang -, Huawei Liu -, Hu Long -, Yingying Yang -, Dianying Liao -, Xiuhui Zhang -. Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. Int J Surg Pathol. 2010;18:488-92 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 2	Gwin K, Buell Gutbrod R, Tretiakova M, Montag A. Epithelial-to-mesenchymal transition in metaplastic breast carcinomas with chondroid differentiation: expression of the E-cadherin repressor Snail. Appl Immunohistochem Mol Morphol. 2010;18:526-31 pubmed publisher
immunohistochemistry; human; 1:100; fig 2	Koensgen D, Freitag C, Klaman I, Dahl E, Mustea A, Chekerov R, et al. Expression and localization of e-cadherin in epithelial ovarian cancer. Anticancer Res. 2010;30:2525-30 pubmed
immunocytochemistry; human; fig 3 western blot; human; fig 2	Rozich R, Mills D, Brilliant K, Callanan H, Yang D, Tantravahi U, et al. Accumulation of neoplastic traits prior to spontaneous in vitro transformation of rat cholangiocytes determines susceptibility to activated ErbB-2/Neu. Exp Mol Pathol. 2010;89:248-59 pubmed publisher
immunohistochemistry - paraffin section; human; 1:800; fig 3	Kim H, Kim G, Kim Y, Park Y, Song J, Lim S. Stromal CD10 expression and relationship to the E-cadherin/beta-catenin complex in breast carcinoma. Histopathology. 2010;56:708-19 pubmed publisher
immunocytochemistry; mouse; 1:50; fig 1	Alarcon V. Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol Reprod. 2010;83:347-58 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 3	Sato Y, Harada K, Itatsu K, Ikeda H, Kakuda Y, Shimomura S, et al. Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma. Am J Pathol. 2010;177:141-52 pubmed publisher
immunohistochemistry; human; 1:200; fig 4	Qi H, Zheng X, Yuan X, Pflugfelder S, Li D. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010;225:180-5 pubmed publisher
immunohistochemistry - paraffin section; human; 1:40; fig 1	Rosa M, Mohammadi A, Masood S. Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. Pathol Res Pract. 2010;206:544-9 pubmed publisher
immunohistochemistry - paraffin section; human; tbl 1	Giusiano S, Secq V, Carcopino X, Carpentier S, Andrac L, Lavaut M, et al. Immunohistochemical profiling of node negative breast carcinomas allows prediction of metastatic risk. Int J Oncol. 2010;36:889-98 pubmed
immunohistochemistry - paraffin section; human; 1:100; fig 4	Ferreira E, Gobbi H, Saraiva B, Cassali G. Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis. BMC Cancer. 2010;10:61 pubmed publisher
immunohistochemistry - paraffin section; human	Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T. Angiosarcoma-like metastatic carcinoma of the liver. Pathol Res Pract. 2010;206:484-8 pubmed publisher
immunohistochemistry; human; 1:100; fig 3	Asioli S, Erickson L, Sebo T, Zhang J, Jin L, Thompson G, et al. Papillary thyroid carcinoma with prominent hobnail features: a new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of eight cases. Am J Surg Pathol. 2010;34:44-52 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 6 western blot; human; 1:500; fig 3	Lundgren K, Nordenskjold B, Landberg G. Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer. Br J Cancer. 2009;101:1769-81 pubmed publisher
immunocytochemistry; human; fig 5	Zhang D, Lafortune T, Krishnamurthy S, Esteva F, Cristofanilli M, Liu P, et al. Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer. Clin Cancer Res. 2009;15:6639-48 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Graesslin O, Antoine M, Chopier J, Seror J, Flahault A, Callard P, et al. Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy. Eur J Surg Oncol. 2010;36:170-5 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Polton G, Brearley M, Green L, Scase T. Expression of E-cadherin in canine anal sac gland carcinoma and its association with survival. Vet Comp Oncol. 2007;5:232-8 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Zou J, Yang H, Chen F, Zhao H, Lin P, Zhang J, et al. Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. Eur J Cancer Prev. 2010;19:11-7 pubmed publisher
immunohistochemistry - paraffin section; human; fig 5	Weiswald L, Richon S, Validire P, Briffod M, Lai Kuen R, Cordelières F, et al. Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness. Br J Cancer. 2009;101:473-82 pubmed publisher
immunohistochemistry; dogs; fig 1	Pires I, Queiroga F, Alves A, Silva F, Lopes C. Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. Anticancer Res. 2009;29:2713-7 pubmed
immunohistochemistry; human; 1:50; fig 1	Zhu Y, Ye D, Yao X, Zhang S, Dai B, Zhang H, et al. Clinicopathological characteristics, management and outcome of metastatic penoscrotal extramammary Paget's disease. Br J Dermatol. 2009;161:577-82 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 1	Ohashi M, Kusumi T, Sato F, Kudo Y, Jin H, Akasaka H, et al. Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma. Biomed Res. 2009;30:79-86 pubmed
immunocytochemistry; human; 1 ug/ml; fig 1	Elwi A, Damaraju V, Kuzma M, Mowles D, Baldwin S, Young J, et al. Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3. Am J Physiol Renal Physiol. 2009;296:F1439-51 pubmed publisher
immunohistochemistry; human	Charpin C, Giusiano S, Secq V, Carpentier S, Andrac L, Lavaut M, et al. Quantitative immunocytochemical profile to predict early outcome of disease in triple-negative breast carcinomas. Int J Oncol. 2009;34:983-93 pubmed
immunohistochemistry; human; tbl 4	Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira Carriço R, Senz J, et al. Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology. 2009;136:2137-48 pubmed publisher
immunocytochemistry; human; fig 1b	Sarrio D, Palacios J, Hergueta Redondo M, Gomez Lopez G, Cano A, Moreno Bueno G. Functional characterization of E- and P-cadherin in invasive breast cancer cells. BMC Cancer. 2009;9:74 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50; tbl 2	Gil da Costa R, Santos M, Amorim I, Lopes C, Pereira P, Faustino A. An immunohistochemical study of feline endometrial adenocarcinoma. J Comp Pathol. 2009;140:254-9 pubmed publisher
western blot; dogs; fig 1 western blot; human; fig 1	Pinho S, Osorio H, Nita Lazar M, Gomes J, Lopes C, Gartner F, et al. Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochem Biophys Res Commun. 2009;379:1091-6 pubmed publisher
immunohistochemistry - frozen section; human; 1:100; fig 1	Alanne M, Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J Histochem Cytochem. 2009;57:523-9 pubmed publisher
immunohistochemistry - paraffin section; human; tbl 1	Charpin C, Secq V, Giusiano S, Carpentier S, Andrac L, Lavaut M, et al. A signature predictive of disease outcome in breast carcinomas, identified by quantitative immunocytochemical assays. Int J Cancer. 2009;124:2124-34 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Patriarca C, Colombo P, Pio Taronna A, Wesseling J, Franchi G, Guddo F, et al. Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1). Int J Surg Pathol. 2009;17:99-106 pubmed publisher
immunohistochemistry - paraffin section; human; 1:2000	Rodriguez F, Scheithauer B, Giannini C, Bryant S, Jenkins R. Epithelial and pseudoepithelial differentiation in glioblastoma and gliosarcoma: a comparative morphologic and molecular genetic study. Cancer. 2008;113:2779-89 pubmed publisher
immunohistochemistry - paraffin section; human; 2.5 ug/ml; fig 2	Saha B, Kaur P, Tsao Wei D, Naritoku W, Groshen S, Datar R, et al. Unmethylated E-cadherin gene expression is significantly associated with metastatic human prostate cancer cells in bone. Prostate. 2008;68:1681-8 pubmed publisher
western blot; human; 1:1000; fig 5a	Mosnier J, Kandel C, Cazals Hatem D, Bou Hanna C, Gournay J, Jarry A, et al. N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. Mod Pathol. 2009;22:182-90 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; tbl 2	Simpson P, Reis Filho J, Lambros M, Jones C, Steele D, Mackay A, et al. Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas. J Pathol. 2008;215:231-44 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Laser J, Cangiarella J, Singh B, Melamed J, Chiriboga L, Yee H, et al. Invasive lobular carcinoma of the breast: role of endothelial lymphatic marker D2-40. Ann Clin Lab Sci. 2008;38:99-104 pubmed
immunohistochemistry - paraffin section; human; 1:40	Fondrevelle M, Kantelip B, Reiter R, Chopin D, Thiery J, Monnien F, et al. The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status. Urol Oncol. 2009;27:268-76 pubmed publisher
immunohistochemistry - frozen section; human; fig 2	Fevre Montange M, Grand S, Champier J, Hoffmann D, Pasquier B, Jouvet A. Bcl-2 expression in a papillary tumor of the pineal region. Neuropathology. 2008;28:660-3 pubmed publisher
immunohistochemistry; human; 1:100; tbl 2	MacGrogan G, Arnould L, de Mascarel I, Vincent Salomon A, Penault Llorca F, Lacroix Triki M, et al. Impact of immunohistochemical markers, CK5/6 and E-cadherin on diagnostic agreement in non-invasive proliferative breast lesions. Histopathology. 2008;52:689-97 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Boone J, van Hillegersberg R, van Diest P, Offerhaus G, Rinkes I, Kate F. Validation of tissue microarray technology in squamous cell carcinoma of the esophagus. Virchows Arch. 2008;452:507-14 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 5	Sawada K, Mitra A, Radjabi A, Bhaskar V, Kistner E, Tretiakova M, et al. Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res. 2008;68:2329-39 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 4	Liu X, Pan M, Lu Z, Wu B, Rao Q, Zhou Z, et al. Expression of Wnt-5a and its clinicopathological significance in hepatocellular carcinoma. Dig Liver Dis. 2008;40:560-7 pubmed publisher
immunohistochemistry - frozen section; human; 1:100	Shi S, Liu C, Pootrakul L, Tang L, Young A, Chen R, et al. Evaluation of the value of frozen tissue section used as "gold standard" for immunohistochemistry. Am J Clin Pathol. 2008;129:358-66 pubmed publisher
western blot; human; fig 6	Wu J, Yan H, Chen W, Chen W, Wang C, Chi Y, et al. JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC. Exp Cell Res. 2008;314:421-9 pubmed publisher
immunohistochemistry - paraffin section; rat; fig 3	Sato Y, Harada K, Ozaki S, Furubo S, Kizawa K, Sanzen T, et al. Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat. Am J Pathol. 2007;171:1859-71 pubmed
immunohistochemistry - paraffin section; human; fig 1a	Saha B, Arase A, Imam S, Tsao Wei D, Naritoku W, Groshen S, et al. Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone. Prostate. 2008;68:78-84 pubmed
immunohistochemistry - paraffin section; human; 1:200	Itatsu K, Zen Y, Ohira S, Ishikawa A, Sato Y, Harada K, et al. Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis. Liver Int. 2007;27:1174-84 pubmed
immunohistochemistry - paraffin section; human	Karacali B, Vamvakidou A, Tozeren A. Automated recognition of cell phenotypes in histology images based on membrane- and nuclei-targeting biomarkers. BMC Med Imaging. 2007;7:7 pubmed
western blot; human; 1:1500; fig 3	Angelucci C, Iacopino F, Ferracuti S, Urbano R, Sica G. Recombinant human IFN-beta affects androgen receptor level, neuroendocrine differentiation, cell adhesion, and motility in prostate cancer cells. J Interferon Cytokine Res. 2007;27:643-52 pubmed
immunohistochemistry; human; 1:2000; tbl 3	Goldstein N, Decker D, Severson D, Schell S, Vicini F, Margolis J, et al. Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy. Cancer. 2007;110:1687-96 pubmed
immunohistochemistry; dogs; 1:100	Gama A, Paredes J, Gartner F, Alves A, Schmitt F. Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival. Vet J. 2008;177:45-53 pubmed
immunohistochemistry; dogs; fig 3	Pinho S, Matos A, Lopes C, Marcos N, Carvalheira J, Reis C, et al. Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression. BMC Cancer. 2007;7:124 pubmed
immunohistochemistry; human	Leibl S, Regitnig P, Moinfar F. Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. Histopathology. 2007;50:859-65 pubmed
immunohistochemistry - paraffin section; human; 1:320	Norton J, Ham C, Van Dam J, Jeffrey R, Longacre T, Huntsman D, et al. CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. Ann Surg. 2007;245:873-9 pubmed
immunohistochemistry - paraffin section; human; fig 1	De Matos A, Lopes C, Faustino A, Carvalheira J, Rutteman G, Gärtner M. E-cadherin, beta-catenin, invasion and lymph node metastases in canine malignant mammary tumours. APMIS. 2007;115:327-34 pubmed
immunohistochemistry - paraffin section; human; 1:50	Zhu Y, Zhou X, Yao X, Dai B, Ye D. The prognostic significance of p53, Ki-67, epithelial cadherin and matrix metalloproteinase-9 in penile squamous cell carcinoma treated with surgery. BJU Int. 2007;100:204-8 pubmed
immunocytochemistry; human; 1:200; fig 2D western blot; human; 1:1000; fig 3C	Stucke V, Timmerman E, Vandekerckhove J, Gevaert K, Hall A. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Mol Biol Cell. 2007;18:1744-55 pubmed
immunocytochemistry; human; 1:300; fig 5	Symowicz J, Adley B, Gleason K, Johnson J, Ghosh S, Fishman D, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 2007;67:2030-9 pubmed
western blot; human; fig 3	Endemann M, Bergmeister H, Bidmon B, Boehm M, Csaicsich D, Malaga Dieguez L, et al. Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis. Am J Physiol Renal Physiol. 2007;292:F47-56 pubmed
immunohistochemistry; human; 1:200; tbl 1	Reis Filho J, Simpson P, Turner N, Lambros M, Jones C, Mackay A, et al. FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res. 2006;12:6652-62 pubmed
immunohistochemistry - paraffin section; human; 1:200; fig 1	Bobrich E, Braumann C, Opitz I, Menenakos C, Kristiansen G, Jacobi C. Influence of intraperitoneal application of taurolidine/heparin on expression of adhesion molecules and colon cancer in rats undergoing laparoscopy. J Surg Res. 2007;137:75-82 pubmed
immunohistochemistry - frozen section; human	Steenvoorden M, Tolboom T, van der Pluijm G, Lowik C, Visser C, Degroot J, et al. Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics. Arthritis Res Ther. 2006;8:R165 pubmed
immunocytochemistry; dogs; fig S1	Martín Villar E, Megias D, Castel S, Yurrita M, Vilaró S, Quintanilla M. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci. 2006;119:4541-53 pubmed
immunohistochemistry; dogs; 1:200; fig 5	Moreno Bueno G, Cubillo E, Sarrio D, Peinado H, Rodriguez Pinilla S, Villa S, et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res. 2006;66:9543-56 pubmed
immunohistochemistry - paraffin section; human; fig 2 immunocytochemistry; human; fig 3 western blot; human; fig 3	Lee T, Poon R, Yuen A, Ling M, Kwok W, Wang X, et al. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res. 2006;12:5369-76 pubmed
immunohistochemistry - paraffin section; human; 1:200	Baker K, Chong G, Foulkes W, Jass J. Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology. 2006;49:371-80 pubmed
immunohistochemistry - paraffin section; rhesus macaque	Wood C, Usborne A, Starost M, Tarara R, Hill L, Wilkinson L, et al. Hyperplastic and neoplastic lesions of the mammary gland in macaques. Vet Pathol. 2006;43:471-83 pubmed
immunohistochemistry - paraffin section; human	Guarino M, Ballabio G, Rubino B, Nebuloni M, Tosoni A. Soft tissue sacrococcygeal chordoma with intracytoplasmic filamentous inclusions. Pathol Res Pract. 2005;201:699-704 pubmed
western blot; human; 1:500; fig 3	Berglund P, Stighall M, Jirstrom K, Borgquist S, Sjölander A, Hedenfalk I, et al. Cyclin E overexpression obstructs infiltrative behavior in breast cancer: a novel role reflected in the growth pattern of medullary breast cancers. Cancer Res. 2005;65:9727-34 pubmed
immunohistochemistry - paraffin section; human; 1:400; tbl 2	Sakamoto K, Watanabe M, de la Cruz C, Honda H, Ise H, Mitsui K, et al. Primary invasive micropapillary carcinoma of the colon. Histopathology. 2005;47:479-84 pubmed
immunocytochemistry; human; fig 5	Veveris Lowe T, Lawrence M, Collard R, Bui L, Herington A, Nicol D, et al. Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. Endocr Relat Cancer. 2005;12:631-43 pubmed
immunohistochemistry - paraffin section; human; 1:400; tbl 2	Pelosi G, Scarpa A, Veronesi G, Spaggiari L, Del Curto B, Moore P, et al. A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expression. Virchows Arch. 2005;447:969-77 pubmed
western blot; human	Shiraishi K, Tsuzaka K, Yoshimoto K, Kumazawa C, Nozaki K, Abe T, et al. Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion. J Immunol. 2005;175:1014-21 pubmed
immunohistochemistry - paraffin section; human; 1:40	Kwon G, Yoo B, Koh K, Cho J, Park W, Park C. Promoter methylation of E-cadherin in hepatocellular carcinomas and dysplastic nodules. J Korean Med Sci. 2005;20:242-7 pubmed
immunohistochemistry - paraffin section; human; 1:400; tbl 2	Pelosi G, Scarpa A, Puppa G, Veronesi G, Spaggiari L, Pasini F, et al. Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. Cancer. 2005;103:1154-64 pubmed
immunohistochemistry - paraffin section; human; tbl 1	Langner C, Ratschek M, Rehak P, Tsybrovskyy O, Zigeuner R. The pT1a and pT1b category subdivision in renal cell carcinoma: is it reflected by differences in tumour biology?. BJU Int. 2005;95:310-4 pubmed
immunohistochemistry - paraffin section; human; 1:40	Wheeler D, Tai L, Bratthauer G, Waldner D, Tavassoli F. Tubulolobular carcinoma of the breast: an analysis of 27 cases of a tumor with a hybrid morphology and immunoprofile. Am J Surg Pathol. 2004;28:1587-93 pubmed
immunohistochemistry - paraffin section; human; 1:500 immunocytochemistry; human; 1:100	Martín Villar E, Scholl F, Gamallo C, Yurrita M, Muñoz Guerra M, Cruces J, et al. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer. 2005;113:899-910 pubmed
immunocytochemistry; human; fig 4	Zeng R, Li X, Gorodeski G. Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation. J Clin Endocrinol Metab. 2004;89:5145-55 pubmed
immunohistochemistry - paraffin section; human	Lyakhovitsky A, Barzilai A, Fogel M, Trau H, Huszar M. Expression of e-cadherin and beta-catenin in cutaneous squamous cell carcinoma and its precursors. Am J Dermatopathol. 2004;26:372-8 pubmed
immunohistochemistry; human; 1:50; fig 3	Sastre Garau X, Genin P, Rousseau A, Al Ghuzlan A, Nicolas A, Freneaux P, et al. Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast. Histopathology. 2004;45:142-7 pubmed
immunohistochemistry - paraffin section; human; 1:100	Aubert S, Duchene F, Augusto D, Llinares K, Lemaitre L, Gosselin B, et al. Low-grade tubular myxoid renal tumors: a clinicopathological study of 3 cases. Int J Surg Pathol. 2004;12:179-83 pubmed
immunohistochemistry - paraffin section; human; 1:200; fig 1 western blot; human; 1:1000; fig 4	Sarrio D, Perez Mies B, Hardisson D, Moreno Bueno G, Suárez A, Cano A, et al. Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene. 2004;23:3272-83 pubmed
immunohistochemistry; human; 1:50; fig 1	Slobodov G, Feloney M, Gran C, Kyker K, Hurst R, Culkin D. Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis. J Urol. 2004;171:1554-8 pubmed
immunohistochemistry - paraffin section; human; fig 1	Nishioka H, Haraoka J, Akada K. Fibrous bodies are associated with lower GH production and decreased expression of E-cadherin in GH-producing pituitary adenomas. Clin Endocrinol (Oxf). 2003;59:768-72 pubmed
immunohistochemistry - paraffin section; human; 1:400	De La Cruz C, Moriya T, Endoh M, Watanabe M, Takeyama J, Yang M, et al. Invasive micropapillary carcinoma of the breast: clinicopathological and immunohistochemical study. Pathol Int. 2004;54:90-6 pubmed
immunohistochemistry - paraffin section; human; fig 4	Alami J, Williams B, Yeger H. Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer. 2003;107:365-74 pubmed
immunohistochemistry - paraffin section; human; 1:50 western blot; human; 1:50	Alami J, Williams B, Yeger H. Differential expression of E-cadherin and beta catenin in primary and metastatic Wilms's tumours. Mol Pathol. 2003;56:218-25 pubmed
immunohistochemistry - paraffin section; human	Fidder H, Barshack I, Chen Shtoyerman R, Onaca N, Goldberg I, Rath P, et al. Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers. Dig Dis Sci. 2003;48:1102-5 pubmed
immunohistochemistry - paraffin section; human; fig 1	Sarrio D, Moreno Bueno G, Hardisson D, Sánchez Estevez C, Guo M, Herman J, et al. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer. 2003;106:208-15 pubmed
immunocytochemistry; mouse; 1:100	Luo Y, Radice G. Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus. J Cell Sci. 2003;116:1471-9 pubmed
immunohistochemistry; human; tbl 2	Bratthauer G, Moinfar F, Stamatakos M, Mezzetti T, Shekitka K, Man Y, et al. Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias. Hum Pathol. 2002;33:620-7 pubmed
immunohistochemistry - paraffin section; mouse; 1:100; fig 2 western blot; mouse; 1:1000; fig 1	Ferreira Cornwell M, Luo Y, Narula N, Lenox J, Lieberman M, Radice G. Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart. J Cell Sci. 2002;115:1623-34 pubmed
immunohistochemistry; human	Mert G. National action plan on Breast Cancer Workshop on Multicultural Aspects of Breast Cancer Etiology: recommendations of the workshop. Cancer. 2002;94:2113 pubmed
immunohistochemistry - paraffin section; human; 1:200	Laskin W, Miettinen M. Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues. Arch Pathol Lab Med. 2002;126:425-31 pubmed
immunohistochemistry - paraffin section; human; 1:50; fig 4	Goldstein N, Kestin L, Vicini F. Clinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast. Cancer. 2001;92:738-47 pubmed
immunohistochemistry - paraffin section; human	Barshack I, Goldberg I, Chowers Y, Weiss B, Horowitz A, Kopolovic J. Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. J Clin Pathol. 2001;54:684-8 pubmed
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product information

Product Type :

Antibody

Product Name :

E-cadherin Monoclonal Antibody (4A2C7)

Catalog # :

33-4000

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry: 2-10 ug/mL, Immunoprecipitation: 2-5 ug, Western Blot: 1 ug/mL

Species :

Human

Clone :

4A2C7

Isotype :

IgG1, kappa

Storage :

-20 C

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Immunogen :

Recombinant MBP fusion protein corresponding to the cytoplasmic domain of human E-cadherin

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2-10 ug/mL, Immunoprecipitation: 2-5 ug, Western Blot: 1 ug/mL

Aliases :

AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin

more info or order :

Invitrogen product webpage