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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-STAT1 (Tyr701) Monoclonal Antibody (ST1P-11A5)
catalog :
33-3400
quantity :
50 µg
price :
US 454.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
ST1P-11A5
reactivity :
African green monkey, human, mouse, rat, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1c
Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed publisher
  • flow cytometry; African green monkey; fig 2b
  • western blot; African green monkey; fig 2c
Ouwendijk W, van Veen S, Mahalingam R, Verjans G. Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol. 2017;: pubmed publisher
  • western blot; mouse; 1:1000; fig 7a
He C, Medley S, Hu T, Hinsdale M, Lupu F, Virmani R, et al. PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun. 2015;6:7770 pubmed publisher
  • western blot; human
Ainsua Enrich E, Serrano Candelas E, Álvarez Errico D, Picado C, Sayós J, Rivera J, et al. The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. J Immunol. 2015;194:4309-18 pubmed publisher
  • western blot; human; 1:10000
Xiang M, Birkbak N, Vafaizadeh V, Walker S, Yeh J, Liu S, et al. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-?B to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal. 2014;7:ra11 pubmed publisher
  • western blot; human; fig 6
Yu J, Li X, Wang Y, Li B, Li H, Li Y, et al. PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1. PLoS ONE. 2011;6:e19511 pubmed publisher
  • immunohistochemistry - paraffin section; rhesus macaque; fig 7
  • immunocytochemistry; rhesus macaque; fig 8
de Lang A, Baas T, Teal T, Leijten L, Rain B, Osterhaus A, et al. Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. PLoS Pathog. 2007;3:e112 pubmed
  • western blot; rat; fig 3
Alblas J, Honing H, De Lavalette C, Brown M, Dijkstra C, van den Berg T. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Mol Cell Biol. 2005;25:7181-92 pubmed
  • western blot; mouse
Aksoy E, Zouain C, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, et al. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J Biol Chem. 2005;280:277-83 pubmed
  • western blot; rat; fig 4
Parkinson E, Townsend P, Stephanou A, Latchman D, Eaton S, Pierro A. The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation. J Pediatr Surg. 2004;39:696-701 pubmed
  • western blot; human; fig 2
Duensing A, Medeiros F, McConarty B, Joseph N, Panigrahy D, Singer S, et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene. 2004;23:3999-4006 pubmed
  • western blot; human; 1 ug/ml; fig 7
Nepomuceno R, Balatoni C, Natkunam Y, Snow A, Krams S, Martinez O. Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res. 2003;63:4472-80 pubmed
  • immunoprecipitation; human; fig 2
Nepomuceno R, Snow A, Robert Beatty P, Krams S, Martinez O. Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder. Transplantation. 2002;74:396-402 pubmed
Frost E, Ford E, Peters A, Reed N, McLaughlin E, Baker M, et al. Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line. Reprod Fertil Dev. 2020;32:1027-1039 pubmed publisher
Keller K, Yang Y, Sun Y, Walter M, Wirtz M. Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture. Mol Vis. 2019;25:266-282 pubmed
Fernández Laso V, Sastre C, Méndez Barbero N, Egido J, Martin Ventura J, Gomez Guerrero C, et al. TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice. Sci Rep. 2017;7:46679 pubmed publisher
Stuart J, Sumner R, Lu Y, Snowden J, Smith G. Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2. PLoS Pathog. 2016;12:e1005955 pubmed publisher
Nancy P, Tagliani E, Tay C, Asp P, Levy D, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012;336:1317-21 pubmed publisher
Marotta L, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker S, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44?CD24? stem cell-like breast cancer cells in human tumors. J Clin Invest. 2011;121:2723-35 pubmed publisher
Ho M, Leu S, Sun G, Tao M, Tang S, Sun K. IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities. J Immunol. 2009;183:6217-26 pubmed publisher
Nelson E, Walker S, Li W, Liu X, Frank D. Identification of human STAT5-dependent gene regulatory elements based on interspecies homology. J Biol Chem. 2006;281:26216-24 pubmed
Zhang Y, Turkson J, Carter Su C, Smithgall T, Levitzki A, Kraker A, et al. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J Biol Chem. 2000;275:24935-44 pubmed
product information
Product Type :
Antibody
Product Name :
Phospho-STAT1 (Tyr701) Monoclonal Antibody (ST1P-11A5)
Catalog # :
33-3400
Quantity :
50 µg
Price :
US 454.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
ChIP assay: 5 µg, ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 0.5-2 µg/mL
Species :
Human, Mouse
Clone :
ST1P-11A5
Isotype :
IgG2a, kappa
Storage :
-20°C
Description :
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
Immunogen :
Synthetic phospho peptide encompassing the conserved C-terminal site (Y701) of murine STAT1 protein
Format :
Liquid
Applications w/Dilutions :
ChIP assay: 5 µg, ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 0.5-2 µg/mL
Aliases :
2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA