Lamin B2 Monoclonal Antibody (E-3) | Invitrogen 33-2100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Lamin B2 Monoclonal Antibody (E-3)

catalog :

33-2100

quantity :

100 µg

price :

US 401.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

E-3

reactivity :

human, mouse, rat, chicken

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:100; fig 1 western blot; rat; 1:1000; fig 1	Vincent K, Cornea V, Jong Y, Laferriere A, Kumar N, Mickeviciute A, et al. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016;7:10604 pubmed publisher
other; human; loading ...; fig st1	Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:400	Jung H, Tatar A, Tu Y, Nobumori C, Yang S, Goulbourne C, et al. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol. 2014;34:4534-44 pubmed publisher
immunohistochemistry - paraffin section; mouse western blot; mouse	Lee J, Tu Y, Tatar A, Wu D, Nobumori C, Jung H, et al. Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014;25:1666-75 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; fig 6 western blot; mouse; 1:400; fig 1	Jung H, Nobumori C, Goulbourne C, Tu Y, Lee J, Tatar A, et al. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013;110:E1923-32 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Kim Y, Sharov A, McDole K, Cheng M, Hao H, Fan C, et al. Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011;334:1706-10 pubmed publisher
immunohistochemistry; rat; 1:100; fig 1 western blot; rat; 1:100; fig 5	Wakabayashi T, Mori T, Hirahara Y, Koike T, Kubota Y, Takamori Y, et al. Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina. Histochem Cell Biol. 2011;136:427-36 pubmed publisher
	Bertero A, Fields P, Smith A, Leonard A, Beussman K, Sniadecki N, et al. Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. J Cell Biol. 2019;218:2919-2944 pubmed publisher
	Takamori Y, Hirahara Y, Wakabayashi T, Mori T, Koike T, Kataoka Y, et al. Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex. IBRO Rep. 2018;5:99-109 pubmed publisher
	Müller B, Ellinwood N, Lorenz B, Stieger K. Detection of DNA Double Strand Breaks by γH2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues. Front Neurosci. 2018;12:286 pubmed publisher
	Gigante C, Dibattista M, Dong F, Zheng X, Yue S, Young S, et al. Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation. Nat Commun. 2017;8:15098 pubmed publisher
	Montagne R, Baranzelli A, Muharram G, Catherine L, Lesaffre M, Vinchent A, et al. MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering. Oncotarget. 2017;8:11268-11283 pubmed publisher
	Jung H, Coffinier C, Choe Y, Beigneux A, Davies B, Yang S, et al. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012;109:E423-31 pubmed publisher
	Hass M, Yankner B. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005;280:36895-904 pubmed
	Jong Y, Kumar V, Kingston A, Romano C, O Malley K. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem. 2005;280:30469-80 pubmed
	O Malley K, Jong Y, Gonchar Y, Burkhalter A, Romano C. Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons. J Biol Chem. 2003;278:28210-9 pubmed
	Riefler G, Firestein B. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J Biol Chem. 2001;276:48262-8 pubmed

product information

Product Type :

Antibody

Product Name :

Lamin B2 Monoclonal Antibody (E-3)

Catalog # :

33-2100

Quantity :

100 µg

Price :

US 401.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Chicken, Human, Mouse, Rat

Applications :

Immunocytochemistry: 10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 0.5 - 3 µg/mL

Species :

Chicken, Human, Mouse, Rat

Clone :

E-3

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Immunogen :

Extracts from chicken nuclei

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 0.5 - 3 µg/mL

Aliases :

EPM9; fc15d06; im:7142331; LAMB2; lamin; lamin A/C; lamin B2; lamin B2 S homeolog; lamin B3; lamin-B2; Lamin-L(II); LMN2; LMNA; lmnb2; lmnb2.S; lmnb2-a; lmnb2-b; MGC2721; RGD1563803; unnamed protein product; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg

more info or order :

Invitrogen product webpage