Occludin Monoclonal Antibody (OC-3F10), FITC | Invitrogen 33-1511 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Occludin Monoclonal Antibody (OC-3F10), FITC

catalog :

33-1511

quantity :

100 µg

price :

US 454.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

OC-3F10

reactivity :

human, mouse, rat, dogs, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; domestic rabbit; 1:1000; loading ...; fig 6b	Martínez Rendón J, Sánchez Guzmán E, Rueda A, González J, Gulias Cañizo R, Aquino Jarquin G, et al. TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium. J Cell Physiol. 2017;232:1794-1807 pubmed publisher
immunohistochemistry; human; loading ...; fig 1.1	Majka G, Wiecek G, Sróttek M, Spiewak K, Brindell M, Koziel J, et al. The impact of lactoferrin with different levels of metal saturation on the intestinal epithelial barrier function and mucosal inflammation. Biometals. 2016;29:1019-1033 pubmed
	Kutova O, Sencha L, Pospelov A, Dobrynina O, Brilkina A, Cherkasova E, et al. Comparative Analysis of Cell-Cell Contact Abundance in Ovarian Carcinoma Cells Cultured in Two- and Three-Dimensional In Vitro Models. Biology (Basel). 2020;9: pubmed publisher
	Zhang C, Lee H, Shrivastava A, Wang R, McQuiston T, Challberg S, et al. Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling. Cell Rep. 2018;25:598-610.e5 pubmed publisher
	Ben Lagha A, Lebel G, Grenier D. Dual action of highbush blueberry proanthocyanidins on Aggregatibacter actinomycetemcomitans and the host inflammatory response. BMC Complement Altern Med. 2018;18:10 pubmed publisher
	Ortiz Melo M, Sánchez Guzmán E, González Robles A, Valdés J, Gómez Flores E, Castro Muñozledo F. Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier. Biol Open. 2013;2:132-43 pubmed publisher
	Parkinson S, Le Good J, Whelan R, Whitehead P, Parker P. Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J. 2004;23:77-88 pubmed
	Choe M, Sporn P, Swartz M. An in vitro airway wall model of remodeling. Am J Physiol Lung Cell Mol Physiol. 2003;285:L427-33 pubmed
	Marino M, Zheng G, Chiovato L, Pinchera A, Brown D, Andrews D, et al. Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release. J Biol Chem. 2000;275:7125-37 pubmed

product information

Product Type :

Antibody

Product Name :

Occludin Monoclonal Antibody (OC-3F10), FITC

Catalog # :

33-1511

Quantity :

100 µg

Price :

US 454.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL

Species :

Canine, Human, Mouse, Rat

Clone :

OC-3F10

Isotype :

IgG1, kappa

Storage :

4° C, store in dark

Description :

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.

Immunogen :

GST fusion protein consisting of the C-terminal region (~150aa) of human occludin.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL

Aliases :

AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein

more info or order :

Invitrogen product webpage