Occludin Monoclonal Antibody (OC-3F10) | Invitrogen 33-1500 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Occludin Monoclonal Antibody (OC-3F10)

catalog :

33-1500

quantity :

100 ug

price :

US 465.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OC-3F10

reactivity :

hamsters, African green monkey, guinea pig, human, mouse, rat, dogs, bovine, pigs , cat, domestic sheep, Xenopus laevis, domestic rabbit, rhesus macaque

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 496

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; fig 1	Shirasago Y, Shimizu Y, Tanida I, Suzuki T, Suzuki R, Sugiyama K, et al. Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection. Biol Pharm Bull. 2016;39:839-48 pubmed publisher
immunocytochemistry; African green monkey; loading ...; fig 1a	Cegarra C, Cameron B, Chaves C, Dabdoubi T, Do T, Gen xea t B, et al. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family. PLoS ONE. 2022;17:e0274667 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 6a	Sasson E, Anzi S, Bell B, Yakovian O, Zorsky M, Deutsch U, et al. Nano-scale architecture of blood-brain barrier tight-junctions. elife. 2021;10: pubmed publisher
western blot; rat; 1:5000; loading ...; fig 4c immunohistochemistry; African green monkey; 1:100; fig 1d western blot; African green monkey; 1:5000; loading ...; fig 4c	Watanabe D, Nakagawa S, Morofuji Y, Tóth A, Vastag M, Aruga J, et al. Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes. Pharmaceutics. 2021;13: pubmed publisher
immunohistochemistry; mouse; loading ...; fig 7	Sun Y, Wu D, Zeng W, Chen Y, Guo M, Lu B, et al. The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis. Front Cell Infect Microbiol. 2021;11:618265 pubmed publisher
western blot; mouse; loading ...; fig 2e	Ngamsri K, Gamper Tsigaras J, Reutershan J, Konrad F. Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation. Front Med (Lausanne). 2021;8:591790 pubmed publisher
immunohistochemistry; mouse; 1:100; loading ...; fig 4b	Nikolakopoulou A, Wang Y, Ma Q, Sagare A, Montagne A, Huuskonen M, et al. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021;218: pubmed publisher
immunohistochemistry; mouse; loading ...; fig 3c	Vita S, Redell J, Maynard M, Zhao J, Grill R, Dash P, et al. P-glycoprotein Expression Is Upregulated in a Pre-Clinical Model of Traumatic Brain Injury. Neurotrauma Rep. 2020;1:207-217 pubmed publisher
immunohistochemistry; mouse; 1:50; loading ...; fig 8e	Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel M, et al. HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathol. 2020;140:183-208 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2a	Hu H, Hone E, Provencher E, Sprowls S, Farooqi I, Corbin D, et al. MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes. Sci Rep. 2020;10:3233 pubmed publisher
immunocytochemistry; human; loading ...; fig 2e, 6g, s1a immunohistochemistry; human; loading ...; fig 1b immunocytochemistry; dogs; loading ...; fig 1d	Ear J, Saklecha A, Rajapakse N, Choi J, Ghassemian M, Kufareva I, et al. Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. iScience. 2020;23:100859 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5b	Benz F, Wichitnaowarat V, Lehmann M, Germano R, Mihova D, Macas J, et al. Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. elife. 2019;8: pubmed publisher
immunohistochemistry; mouse; loading ...; fig 2d	Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed publisher
immunohistochemistry; human; 1:40; loading ...; fig s1b	DaSilva Arnold S, Kuo C, Davra V, Remache Y, Kim P, Fisher J, et al. ZEB2, a master regulator of the epithelial-mesenchymal transition, mediates trophoblast differentiation. Mol Hum Reprod. 2019;25:61-75 pubmed publisher
immunohistochemistry; human; 1:100; fig 5l	Benedicto I, Lehmann G, Ginsberg M, Nolan D, Bareja R, Elemento O, et al. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun. 2017;8:15374 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 3b	Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed publisher
western blot; mouse; fig 2b	Prasad S, Sajja R, Kaisar M, Park J, Villalba H, Liles T, et al. Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity. Redox Biol. 2017;12:58-69 pubmed publisher
western blot; human; loading ...; fig 2a	Ni Y, Teng T, Li R, Simonyi A, Sun G, Lee J. TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK. PLoS ONE. 2017;12:e0170346 pubmed publisher
immunocytochemistry; human; 1:100; loading ...; fig 4b western blot; human; 1:1000; loading ...; tbl 3	Sivagurunathan S, Palanisamy K, Arunachalam J, Chidambaram S. Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway. Mol Cell Biochem. 2017;427:145-156 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6a western blot; human; 1:1000; loading ...; fig 2a	Lin Z, Zhang Y, Xia Y, Xu X, Jiao X, Sun J. Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway. J Biol Chem. 2016;291:26837-26849 pubmed publisher
immunohistochemistry; human; loading ...; fig 1.1	Majka G, Wiecek G, Sróttek M, Spiewak K, Brindell M, Koziel J, et al. The impact of lactoferrin with different levels of metal saturation on the intestinal epithelial barrier function and mucosal inflammation. Biometals. 2016;29:1019-1033 pubmed
immunocytochemistry; human; 2.5 ug/ml; loading ...; fig 3d	Qian Y, Li C, Jiang A, Ge S, Gu P, Fan X, et al. HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability. J Biol Chem. 2016;291:22977-22987 pubmed
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3a	Wardill H, Bowen J, Van Sebille Y, Secombe K, Coller J, Ball I, et al. TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea. Mol Cancer Ther. 2016;15:2767-2779 pubmed
immunocytochemistry; dogs; 1:200; fig 5 western blot; dogs; 1:1000; fig 8a	Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher
immunocytochemistry; rat; 1:100; loading ...	Zeller P, Legendre A, Jacques S, Fleury M, Gilard F, Tcherkez G, et al. Hepatocytes cocultured with Sertoli cells in bioreactor favors Sertoli barrier tightness in rat. J Appl Toxicol. 2017;37:287-295 pubmed publisher
western blot; mouse; fig 3a	Zhang Z, Yan J, Shi H. Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke. Neurobiol Dis. 2016;95:82-92 pubmed publisher
immunocytochemistry; human; 1:200; fig 2f	Clark P, Al Ahmad A, Qian T, Zhang R, Wilson H, Weichert J, et al. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016;13:3341-9 pubmed publisher
immunohistochemistry - frozen section; rat; 1:100; fig 2	Gao Y, Lui W, Lee W, Cheng C. Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells. Sci Rep. 2016;6:28589 pubmed publisher
immunohistochemistry - frozen section; rat; 2.5 ug/ml; fig 5 immunoprecipitation; rat; 3 ug/ml; fig 5 western blot; rat; 0.5 ug/ml; fig 5	Poon C, Madawala R, Dowland S, Murphy C. Nectin-3 Is Increased in the Cell Junctions of the Uterine Epithelium at Implantation. Reprod Sci. 2016;23:1580-1592 pubmed
immunohistochemistry - paraffin section; mouse; fig 1	Kobayashi K, Tsugami Y, Matsunaga K, Oyama S, Kuki C, Kumura H. Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells. Biochim Biophys Acta. 2016;1863:2006-16 pubmed publisher
immunocytochemistry; mouse; 1:300; fig 4 western blot; mouse; 1:3000; fig 4	Guerrera D, Shah J, Vasileva E, Sluysmans S, Méan I, Jond L, et al. PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. J Biol Chem. 2016;291:11016-29 pubmed publisher
immunocytochemistry; pigs ; 1:100; fig 3	Kwon J, Jeong S, Choi I, Kim N. ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development. PLoS ONE. 2016;11:e0152921 pubmed publisher
immunocytochemistry; human; fig 4	Wardill H, Gibson R, Van Sebille Y, Secombe K, Logan R, Bowen J. A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options. Exp Biol Med (Maywood). 2016;241:1386-94 pubmed publisher
immunocytochemistry; human; 1:200; fig 2	Kuehn A, Kletting S, de Souza Carvalho Wodarz C, Repnik U, Griffiths G, Fischer U, et al. Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier. ALTEX. 2016;33:251-60 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 8	Shukla P, Chaudhry K, Mir H, Gangwar R, Yadav N, Manda B, et al. Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. BMC Cancer. 2016;16:189 pubmed publisher
immunohistochemistry - paraffin section; domestic sheep; 1:50; fig 4	Liu H, Garzoni L, Herry C, Durosier L, Cao M, Burns P, et al. Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate?. Pediatr Crit Care Med. 2016;17:e165-76 pubmed publisher
immunocytochemistry; human; 1:200; fig 6 immunohistochemistry; mouse; 1:200; fig 5	Ibrahim A, Mander S, Hussein K, Elsherbiny N, Smith S, Al Shabrawey M, et al. Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. Oncotarget. 2016;7:8532-45 pubmed publisher
immunohistochemistry; mouse; 1:50; fig 3	Lou N, Takano T, Pei Y, Xavier A, Goldman S, Nedergaard M. Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc Natl Acad Sci U S A. 2016;113:1074-9 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4c western blot; mouse; 1:2000; loading ...; fig 4b	Shi Y, Liu T, Fu J, Xu W, Wu L, Hou A, et al. Vitamin D/VDR signaling attenuates lipopolysaccharideâ€‘induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier. Mol Med Rep. 2016;13:1186-94 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 2	Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, et al. The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat Commun. 2015;6:8989 pubmed publisher
western blot; human; fig 1	Nadeem A, Thomas P, Ulf M, Elena N, Anggakusuma A, Mohamed B, et al. Cell culture-derived HCV cannot infect synovial fibroblasts. Sci Rep. 2015;5:18043 pubmed publisher
immunocytochemistry; human; 1:100; fig s2 ELISA; human; 1:50; fig s2 western blot; human; fig s2	Castro V, Bertrand L, Luethen M, Dabrowski S, Lombardi J, Morgan L, et al. Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation. FASEB J. 2016;30:1234-46 pubmed publisher
immunocytochemistry; human; 1:200; fig 2	Stebbins M, Wilson H, Canfield S, Qian T, Palecek S, Shusta E. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods. 2016;101:93-102 pubmed publisher
western blot; human; fig 1,2,3	Cravo A, Carter E, Erkan M, Harvey E, Furutani Seiki M, MRSNY R. Hippo pathway elements Co-localize with Occludin: A possible sensor system in pancreatic epithelial cells. Tissue Barriers. 2015;3:e1037948 pubmed publisher
immunohistochemistry; human; 5 ug/ml	Wardill H, Logan R, Bowen J, Van Sebille Y, Gibson R. Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer. Support Care Cancer. 2016;24:1779-88 pubmed publisher
immunocytochemistry; human; fig 4	Blume C, Reale R, Held M, Millar T, Collins J, Davies D, et al. Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics. PLoS ONE. 2015;10:e0139872 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 2b	Lee J, Tato C, Joyce Shaikh B, Gulen M, Gulan F, Cayatte C, et al. Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015;43:727-38 pubmed publisher
immunocytochemistry; human; 1:200; fig 2b	Valere K, Rapista A, Eugenin E, Lu W, Chang T. Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission. Viral Immunol. 2015;28:609-15 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:250	Brkic M, Balusu S, Van Wonterghem E, GorlÃ© N, Benilova I, Kremer A, et al. Amyloid Î² Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. J Neurosci. 2015;35:12766-78 pubmed publisher
immunocytochemistry; human; 1:50 western blot; human; 1:200	Zhao Y, Zhao L, Wang P, Miao Y, Liu Y, Wang Z, et al. Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via KrÃ¼ppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin. J Neurosci Res. 2015;93:1891-902 pubmed publisher
immunohistochemistry; human; 1:100; fig 3b	Abdayem R, Callejon S, Portes P, Kirilov P, Demarne F, Pirot F, et al. Modulation of transepithelial electric resistance (TEER) in reconstructed human epidermis by excipients known to permeate intestinal tight junctions. Exp Dermatol. 2015;24:686-91 pubmed publisher
immunocytochemistry; rat; 1:500; loading ...; fig 3c western blot; rat; 1:500; loading ...; fig 2a	Cong X, Zhang Y, Li J, Mei M, Ding C, Xiang R, et al. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells. J Cell Sci. 2015;128:2271-86 pubmed publisher
immunocytochemistry; human; 2.5 ug/ml	Staat C, Coisne C, Dabrowski S, Stamatovic S, Andjelkovic A, Wolburg H, et al. Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers. Biomaterials. 2015;54:9-20 pubmed publisher
western blot; mouse	Wu S, Yi J, Zhang Y, Zhou J, Sun J. Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model. Physiol Rep. 2015;3: pubmed publisher
immunohistochemistry; rat	Ward C, Schlingmann B, Stecenko A, Guidot D, Koval M. NF-ÎºB inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers. 2015;3:e982424 pubmed publisher
western blot; rhesus macaque; fig s1b	Scull M, Shi C, De Jong Y, Gerold G, Ries M, von Schaewen M, et al. Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology. 2015;62:57-67 pubmed publisher
immunocytochemistry; human; fig 5	Haarmann A, Nowak E, DeiÃŸ A, van der Pol S, Monoranu C, Kooij G, et al. Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin Î±-4-transduced outside-in signalling. Acta Neuropathol. 2015;129:639-52 pubmed publisher
immunohistochemistry; human; fig 6	BazelliÃ¨res E, Conte V, Elosegui Artola A, Serra Picamal X, Bintanel Morcillo M, Roca Cusachs P, et al. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nat Cell Biol. 2015;17:409-20 pubmed publisher
western blot; human; 1:1000	Contreras T, Ricciardi E, Cremonini E, Oteiza P. (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Arch Biochem Biophys. 2015;573:84-91 pubmed publisher
immunocytochemistry; dogs; fig 6 western blot; dogs; fig 3	Fredriksson K, Van Itallie C, Aponte A, Gucek M, Tietgens A, Anderson J. Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. PLoS ONE. 2015;10:e0117074 pubmed publisher
immunohistochemistry; human	Strick Marchand H, DussÃ©aux M, Darche S, Huntington N, Legrand N, Masse Ranson G, et al. A novel mouse model for stable engraftment of a human immune system and human hepatocytes. PLoS ONE. 2015;10:e0119820 pubmed publisher
immunohistochemistry - frozen section; mouse	Sohet F, Lin C, Munji R, Lee S, Ruderisch N, Soung A, et al. LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J Cell Biol. 2015;208:703-11 pubmed publisher
immunohistochemistry - frozen section; human	Röhl M, Tjernlund A, Mehta S, Pettersson P, Bailey R, Broliden K. Comparable mRNA expression of inflammatory markers but lower claudin-1 mRNA levels in foreskin tissue of HSV-2 seropositive versus seronegative asymptomatic Kenyan young men. BMJ Open. 2015;5:e006627 pubmed publisher
western blot; human; fig 6	Momeny M, Saunus J, Marturana F, McCart Reed A, Black D, Sala G, et al. Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget. 2015;6:3932-46 pubmed
immunohistochemistry; human; 1:50	Chajra H, Amstutz B, Schweikert K, Auriol D, Redziniak G, LefÃ¨vre F. Opioid receptor delta as a global modulator of skin differentiation and barrier function repair. Int J Cosmet Sci. 2015;37:386-94 pubmed publisher
immunohistochemistry; mouse	Khairallah H, El Andalousi J, Simard A, Haddad N, Chen Y, Hou J, et al. Claudin-7, -16, and -19 during mouse kidney development. Tissue Barriers. 2014;2:e964547 pubmed publisher
immunohistochemistry; guinea pig	Lee S, Kwon J, Choi I, Kim N. Expression and function of transcription factor AP-2? in early embryonic development of porcine parthenotes. Reprod Fertil Dev. 2015;: pubmed publisher
immunocytochemistry; human; 1:100 western blot; human	Nicolas V, LiÃ©vin Le Moal V. Antisecretory factor peptide AF-16 inhibits the secreted autotransporter toxin-stimulated transcellular and paracellular passages of fluid in cultured human enterocyte-like cells. Infect Immun. 2015;83:907-22 pubmed publisher
immunohistochemistry; human; 1:150	Pienaar I, Lee C, Elson J, McGuinness L, Gentleman S, Kalaria R, et al. Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiol Dis. 2015;74:392-405 pubmed publisher
immunocytochemistry; human; 1:1000	Vitiello E, Ferreira J, Maiato H, Balda M, Matter K. The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion. Nat Commun. 2014;5:5826 pubmed publisher
immunocytochemistry; human western blot; human	Watari A, Hashegawa M, Yagi K, Kondoh M. Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers. Eur J Pharm Biopharm. 2015;89:232-8 pubmed publisher
immunocytochemistry; mouse; 1:500; fig 3	Qiao X, Roth I, FÃ©raille E, Hasler U. Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Cell Cycle. 2014;13:3059-75 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6b	Shirasago Y, Sekizuka T, Saito K, Suzuki T, Wakita T, Hanada K, et al. Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus. Jpn J Infect Dis. 2015;68:81-8 pubmed publisher
immunohistochemistry - frozen section; Xenopus laevis; fig 3	Wiechmann A, Ceresa B, Howard E. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS ONE. 2014;9:e113810 pubmed publisher
immunohistochemistry; mouse; 1:300; fig 4 western blot; mouse; 1:1000	Braniste V, Al Asmakh M, Kowal C, Anuar F, Abbaspour A, TÃ³th M, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6:263ra158 pubmed publisher
western blot; human; 1:1000; fig 3	Lei Q, Qiang F, Chao D, Di W, Guoqian Z, Bo Y, et al. Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-ÎºB and HIF-1Î± signaling pathways. Int J Mol Med. 2014;34:1629-39 pubmed publisher
western blot; human	Casselbrant A, Elias E, FÃ¤ndriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed publisher
western blot; domestic sheep; 1:500	Tao S, Duanmu Y, Dong H, Tian J, Ni Y, Zhao R. A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats. BMC Vet Res. 2014;10:235 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:200; fig 5	WÃ¶genstein K, Szabo S, Lunova M, Wiche G, Haybaeck J, Strnad P, et al. Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules. PLoS ONE. 2014;9:e108323 pubmed publisher
western blot; human	Kelsey L, Katoch P, Ray A, Mitra S, Chakraborty S, Lin M, et al. Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. PLoS ONE. 2014;9:e106437 pubmed publisher
immunohistochemistry - paraffin section; rhesus macaque; 1:400	Gumber S, Nusrat A, Villinger F. Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine. Exp Toxicol Pathol. 2014;66:437-44 pubmed publisher
western blot; human; 1:1000; loading ...; fig 1c	Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, et al. Role of hypervariable region 1 for the interplay of hepatitis C virus with entry factors and lipoproteins. J Virol. 2014;88:12644-55 pubmed publisher
immunohistochemistry; human; 6 ug/ml	Krivega M, Geens M, Van de Velde H. CAR expression in human embryos and hESC illustrates its role in pluripotency and tight junctions. Reproduction. 2014;148:531-44 pubmed publisher
immunocytochemistry; human; fig 3	Ragupathy S, Esmaeili F, Paschoud S, Sublet E, Citi S, Borchard G. Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1. Tissue Barriers. 2014;2:e29166 pubmed publisher
immunohistochemistry; mouse; 1:200	Tawfik A, Markand S, Al Shabrawey M, Mayo J, Reynolds J, Bearden S, et al. Alterations of retinal vasculature in cystathionine-?-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia. Am J Pathol. 2014;184:2573-85 pubmed publisher
immunohistochemistry - frozen section; human; 1:250	Jakimovski D, Schneider H, Frei K, Kennes L, Bertalanffy H. Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma. J Neurosurg. 2014;121:613-20 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 5b	Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol. 2014;15:676-86 pubmed publisher
western blot; rat; 1:1000	Altshuler A, Lamadrid I, Li D, Ma S, Kurre L, Schmid Schonbein G, et al. Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition. PLoS ONE. 2014;9:e96655 pubmed publisher
immunocytochemistry; rat; 1:200 western blot; rat; 1:200	Grosse B, Degrouard J, Jaillard D, Cassio D. Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins. Tissue Barriers. 2013;1:e25210 pubmed publisher
western blot; human	Reaves D, Fagan Solis K, Dunphy K, Oliver S, Scott D, Fleming J. The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior. PLoS ONE. 2014;9:e91747 pubmed publisher
immunocytochemistry; human; loading ...; fig s5	Yang D, Zuo C, Wang X, Meng X, Xue B, Liu N, et al. Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line. Proc Natl Acad Sci U S A. 2014;111:E1264-73 pubmed publisher
immunohistochemistry; guinea pig; 1:250 western blot; guinea pig; 1:500	Wang S, Liu S, Mao J, Wen D. Effect of retinoic acid on the tight junctions of the retinal pigment epithelium-choroid complex of guinea pigs with lens-induced myopia in vivo. Int J Mol Med. 2014;33:825-32 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:150 western blot; mouse; 1:200	Xiao W, Feng Y, Holst J, Hartmann B, Yang H, Teitelbaum D. Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. FASEB J. 2014;28:2073-87 pubmed publisher
immunocytochemistry; human; 1:100 western blot; human	Fiorentino M, Levine M, Sztein M, Fasano A. Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release. PLoS ONE. 2014;9:e85211 pubmed publisher
immunocytochemistry; human; 1:100	Boyer Di Ponio J, El Ayoubi F, Glacial F, Ganeshamoorthy K, Driancourt C, Godet M, et al. Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes. PLoS ONE. 2014;9:e84179 pubmed publisher
western blot; rat; 1:1000	Altshuler A, Richter M, Modestino A, Penn A, Heller M, Schmid Schonbein G. Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. Physiol Rep. 2013;1:e00109 pubmed publisher
western blot; pigs ; 1:500	Zhang S, Liu Z, Heldsinger A, Owyang C, Yu S. Intraluminal acid activates esophageal nodose C fibers after mast cell activation. Am J Physiol Gastrointest Liver Physiol. 2014;306:G200-7 pubmed publisher
immunocytochemistry; dogs western blot; dogs	Rincon Heredia R, Flores Benitez D, Flores Maldonado C, Bonilla Delgado J, García Hernández V, Verdejo Torres O, et al. Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways. Exp Cell Res. 2014;320:108-18 pubmed publisher
immunocytochemistry; mouse; 1:100; fig 2	Sugimoto K, Ichikawa Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, et al. The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. PLoS ONE. 2013;8:e75106 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:100; fig 2	Hernández Monge J, Garay E, Raya Sandino A, Vargas Sierra O, Diaz Chavez J, Popoca Cuaya M, et al. Papillomavirus E6 oncoprotein up-regulates occludin and ZO-2 expression in ovariectomized mice epidermis. Exp Cell Res. 2013;319:2588-603 pubmed publisher
immunocytochemistry; human; fig 3	Hirashima T, Hosokawa Y, Iino T, Nagayama M. On fundamental cellular processes for emergence of collective epithelial movement. Biol Open. 2013;2:660-6 pubmed publisher
immunocytochemistry; human; 1:100; fig 2 immunohistochemistry; human; 1:100; fig 1	Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, et al. Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano. Cell Tissue Res. 2013;354:481-94 pubmed publisher
immunocytochemistry; mouse; fig 5	Soscia D, Sequeira S, Schramm R, Jayarathanam K, Cantara S, Larsen M, et al. Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters. Biomaterials. 2013;34:6773-84 pubmed publisher
immunocytochemistry; rat	Watson P, Paterson J, Thom G, Ginman U, Lundquist S, Webster C. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier. BMC Neurosci. 2013;14:59 pubmed publisher
immunocytochemistry; human; 2.5 ug/ml; fig 5 western blot; human; 2 ug/ml; fig 5	Liu Z, He J. Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors. J Virol. 2013;87:8545-58 pubmed publisher
western blot; human; fig 2	Cheng Y, Lan K, Lee W, Tseng S, Hung L, Lin H, et al. Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle. Clin Sci (Lond). 2013;125:439-48 pubmed publisher
western blot; domestic sheep; 1:5000; fig 2	Szczepkowska A, Lagaraine C, Robert V, Dufourny L, Thiery J, Skipor J. Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods. Neurotoxicol Teratol. 2013;37:63-7 pubmed publisher
western blot; human; fig 4	Sourisseau M, Michta M, Zony C, Israelow B, Hopcraft S, Narbus C, et al. Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies. PLoS Pathog. 2013;9:e1003244 pubmed publisher
western blot; human; fig 8a	Fiorentino M, Lammers K, Levine M, Sztein M, Fasano A. In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines. Front Immunol. 2013;4:17 pubmed publisher
immunocytochemistry; human; fig 2 western blot; human; 1:3000; fig 2	Kirschner N, Rosenthal R, Furuse M, Moll I, Fromm M, Brandner J. Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J Invest Dermatol. 2013;133:1161-9 pubmed publisher
immunocytochemistry; human; loading ...; fig s2	Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, et al. Protein kinase C? inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer. Carcinogenesis. 2013;34:1232-43 pubmed publisher
western blot; human; fig 1, 2	Kim S, Ishida H, Yamane D, Yi M, Swinney D, Foung S, et al. Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry. J Virol. 2013;87:4214-24 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 3	Kissoon Singh V, Moreau F, Trusevych E, Chadee K. Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice. Am J Pathol. 2013;182:852-65 pubmed publisher
immunohistochemistry; mouse; 1:100; fig 4	Stenman L, Holma R, Eggert A, Korpela R. A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids. Am J Physiol Gastrointest Liver Physiol. 2013;304:G227-34 pubmed publisher
immunocytochemistry; human; fig 1	Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, et al. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. Cell Tissue Res. 2013;351:73-84 pubmed publisher
immunocytochemistry; human; 1:250; fig 7 western blot; human; 1:2000; fig 7	Cheung T, Ganatra M, Peters E, Truskey G. Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. Am J Physiol Heart Circ Physiol. 2012;303:H1374-83 pubmed publisher
immunocytochemistry; human; fig 1	Wang J, Novak I. Ion transport in human pancreatic duct epithelium, Capan-1 cells, is regulated by secretin, VIP, acetylcholine, and purinergic receptors. Pancreas. 2013;42:452-60 pubmed publisher
immunocytochemistry; human; fig 5	Cantara S, Soscia D, Sequeira S, Jean Gilles R, Castracane J, Larsen M. Selective functionalization of nanofiber scaffolds to regulate salivary gland epithelial cell proliferation and polarity. Biomaterials. 2012;33:8372-82 pubmed publisher
western blot; human; fig 2	Sandmann L, Wilson M, Back D, Wedemeyer H, Manns M, Steinmann E, et al. Anti-retroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro. Antiviral Res. 2012;96:51-8 pubmed publisher
western blot; rat; 1:500; fig 2	Northrop N, Yamamoto B. Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier. J Neuroimmune Pharmacol. 2012;7:951-68 pubmed publisher
immunohistochemistry; mouse; 1:250; fig 3	Ji K, Tsirka S. Inflammation modulates expression of laminin in the central nervous system following ischemic injury. J Neuroinflammation. 2012;9:159 pubmed publisher
western blot; human	Morel A, Hinkal G, Thomas C, Fauvet F, Courtois Cox S, Wierinckx A, et al. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLoS Genet. 2012;8:e1002723 pubmed publisher
western blot; human; 1:250; fig 4a	Guzman Aranguez A, Woodward A, Pintor J, ARGUESO P. Targeted disruption of core 1 ?1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes. PLoS ONE. 2012;7:e36628 pubmed publisher
immunohistochemistry - paraffin section; rat; 1:50; fig 4a	Rittner H, Amasheh S, Moshourab R, Hackel D, Yamdeu R, Mousa S, et al. Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia. Anesthesiology. 2012;116:1323-34 pubmed publisher
western blot; human; fig 1	Kelsey L, Katoch P, Johnson K, Batra S, Mehta P. Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. PLoS ONE. 2012;7:e32846 pubmed publisher
immunohistochemistry; rat; fig 6	Géraud C, Evdokimov K, Straub B, Peitsch W, Demory A, Dörflinger Y, et al. Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PLoS ONE. 2012;7:e34206 pubmed publisher
immunohistochemistry - frozen section; domestic rabbit; 1:200; fig 2	Jiang X, Guo M, Su J, Lu B, Ma D, Zhang R, et al. Simvastatin blocks blood-brain barrier disruptions induced by elevated cholesterol both in vivo and in vitro. Int J Alzheimers Dis. 2012;2012:109324 pubmed publisher
western blot; human; fig 3	Hsieh J, Lu C, Huang C, Shieh G, Su B, Su Y, et al. Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment. Cancer Lett. 2012;321:36-44 pubmed publisher
immunohistochemistry - paraffin section; domestic rabbit; 1:200; fig 4	Ritchie J, Rui H, Zhou X, Iida T, Kodoma T, Ito S, et al. Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog. 2012;8:e1002593 pubmed publisher
immunocytochemistry; dogs; fig 1 western blot; dogs; fig 2, 4	Dukes J, Whitley P, Chalmers A. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE. 2012;7:e28659 pubmed publisher
immunohistochemistry; human; 1:100; fig 1	Korompay A, Borka K, Lotz G, Somorácz A, Törzsök P, Erdélyi Belle B, et al. Tricellulin expression in normal and neoplastic human pancreas. Histopathology. 2012;60:E76-86 pubmed publisher
immunocytochemistry; human; fig 2	Fernandes I, de Freitas V, Reis C, Mateus N. A new approach on the gastric absorption of anthocyanins. Food Funct. 2012;3:508-16 pubmed publisher
western blot; human; fig 1	Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, et al. Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. Cell Tissue Res. 2011;346:369-81 pubmed publisher
immunohistochemistry - frozen section; human; 2.5 ug/ml; fig 3	Nguyen Hoang A, Chen P, Juarez J, Sachamitr P, Billing B, Bosnjak L, et al. Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa. Am J Physiol Lung Cell Mol Physiol. 2012;302:L226-37 pubmed publisher
western blot; human; fig 2	Lan K, Wang Y, Lee W, Lan K, Tseng S, Hung L, et al. Multiple effects of Honokiol on the life cycle of hepatitis C virus. Liver Int. 2012;32:989-97 pubmed publisher
immunohistochemistry - paraffin section; rat; 1:200; fig 1 western blot; rat; 1:1000; fig 6	Lee S, Shin J, Kwon H, Weiner I, Han K. Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct. Histochem Cell Biol. 2011;136:637-47 pubmed publisher
western blot; mouse; fig 6	Chi F, Wang L, Zheng X, Wu C, Jong A, Sheard M, et al. Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLoS ONE. 2011;6:e25016 pubmed publisher
immunocytochemistry; mouse; fig 5	Carman A, Mills J, Krenz A, Kim D, Bynoe M. Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci. 2011;31:13272-80 pubmed publisher
western blot; mouse; fig 9	Lubarski I, Asher C, Garty H. FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells. Am J Physiol Renal Physiol. 2011;301:F1270-80 pubmed publisher
western blot; human; fig 2	Quaranta M, Vincentini O, Felli C, Spadaro F, Silano M, Moricoli D, et al. Exogenous HIV-1 Nef upsets the IFN-?-induced impairment of human intestinal epithelial integrity. PLoS ONE. 2011;6:e23442 pubmed publisher
immunocytochemistry; human; 1:100; fig 9a	Humen M, Perez P, Liévin Le Moal V. Lipid raft-dependent adhesion of Giardia intestinalis trophozoites to a cultured human enterocyte-like Caco-2/TC7 cell monolayer leads to cytoskeleton-dependent functional injuries. Cell Microbiol. 2011;13:1683-702 pubmed publisher
immunocytochemistry; human; 1:100; fig 2 western blot; human; 1:1000; fig 1	Kojima T, Takasawa A, Kyuno D, Ito T, Yamaguchi H, Hirata K, et al. Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells. Exp Cell Res. 2011;317:2288-98 pubmed publisher
western blot; human; 1:1000; fig 4 immunocytochemistry; dogs; 1:25; fig 1	Dukes J, Fish L, Richardson J, Blaikley E, Burns S, Caunt C, et al. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Mol Biol Cell. 2011;22:3192-205 pubmed publisher
western blot; human; fig 4	Belgiovine C, Chiodi I, Mondello C. Relocalization of cell adhesion molecules during neoplastic transformation of human fibroblasts. Int J Oncol. 2011;39:1199-204 pubmed publisher
immunocytochemistry; human; fig 6	Jahn K, Biazik J, Braet F. GM1 expression in caco-2 cells: characterisation of a fundamental passage-dependent transformation of a cell line. J Pharm Sci. 2011;100:3751-62 pubmed publisher
western blot; human; fig 2	Ciesek S, Westhaus S, Wicht M, Wappler I, Henschen S, Sarrazin C, et al. Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles. J Virol. 2011;85:7613-21 pubmed publisher
western blot; mouse; fig 3	Yan J, Zhang Z, Shi H. HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells. Cell Mol Life Sci. 2012;69:115-28 pubmed publisher
western blot; domestic sheep; 1:5000; fig 1	Lagaraine C, Skipor J, Szczepkowska A, Dufourny L, Thiery J. Tight junction proteins vary in the choroid plexus of ewes according to photoperiod. Brain Res. 2011;1393:44-51 pubmed publisher
western blot; human; fig 2	Kwon Y, Cukierman E, Godwin A. Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion. PLoS ONE. 2011;6:e18872 pubmed publisher
western blot; pigs ; fig 1	Butt O, Buehler P, D Agnillo F. Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol. 2011;178:1316-28 pubmed publisher
immunohistochemistry; mouse; fig 4 western blot; mouse; fig 4	Kirschner N, Haftek M, Niessen C, Behne M, Furuse M, Moll I, et al. CD44 regulates tight-junction assembly and barrier function. J Invest Dermatol. 2011;131:932-43 pubmed publisher
immunocytochemistry; human; 2.5 ug/ml; loading ...; fig 5a western blot; human; loading ...; fig 6a	De Benedetto A, Rafaels N, McGirt L, Ivanov A, Georas S, Cheadle C, et al. Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol. 2011;127:773-86.e1-7 pubmed publisher
immunocytochemistry; human; fig 1	Haarmann A, Deiss A, Prochaska J, Foerch C, Weksler B, Romero I, et al. Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown. PLoS ONE. 2010;5:e13568 pubmed publisher
immunocytochemistry; human; fig s2 western blot; human; fig 2	Eyre N, Drummer H, Beard M. The SR-BI partner PDZK1 facilitates hepatitis C virus entry. PLoS Pathog. 2010;6:e1001130 pubmed publisher
immunocytochemistry; rat; fig 1a	Govindarajan R, Chakraborty S, Johnson K, Falk M, Wheelock M, Johnson K, et al. Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells. Mol Biol Cell. 2010;21:4089-107 pubmed publisher
immunocytochemistry; rat; 1:50; tbl 1 western blot; rat; 1:250; tbl 1	Su L, Mruk D, Lee W, Cheng C. Differential effects of testosterone and TGF-?3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier. Exp Cell Res. 2010;316:2945-60 pubmed publisher
immunocytochemistry; human; fig 2	Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, et al. ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol. 2010;20:1408-14 pubmed publisher
western blot; human; fig 1	Burgel B, Friesland M, Koch A, Manns M, Wedemeyer H, Weissenborn K, et al. Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration. J Viral Hepat. 2011;18:562-70 pubmed publisher
immunocytochemistry; human; 1:100; loading ...; fig 3a	Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, et al. Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells. Am J Pathol. 2010;177:698-712 pubmed publisher
immunocytochemistry; dogs; 1:50; fig 2	Garay E, Patino Lopez G, Islas S, Alarcón L, Canche Pool E, Valle Rios R, et al. CRTAM: A molecule involved in epithelial cell adhesion. J Cell Biochem. 2010;111:111-22 pubmed publisher
immunocytochemistry; human; 1:100; fig 2 western blot; human; 1:1000; fig 2	Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, et al. c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J Cell Physiol. 2010;225:720-33 pubmed publisher
immunohistochemistry; rat; 1:200; fig 5	De la Serre C, Ellis C, Lee J, Hartman A, Rutledge J, Raybould H. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol. 2010;299:G440-8 pubmed publisher
immunocytochemistry; human; loading ...; fig 2a western blot; human; loading ...; fig 3a	Schubert Unkmeir A, Konrad C, Slanina H, Czapek F, Hebling S, Frosch M. Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8. PLoS Pathog. 2010;6:e1000874 pubmed publisher
immunocytochemistry; human; fig 2	Yakovich A, Huang Q, Du J, Jiang B, Barnard J. Vectorial TGFbeta signaling in polarized intestinal epithelial cells. J Cell Physiol. 2010;224:398-404 pubmed publisher
western blot; human; 1:500; fig 3	Ciesek S, Steinmann E, Iken M, Ott M, Helfritz F, Wappler I, et al. Glucocorticosteroids increase cell entry by hepatitis C virus. Gastroenterology. 2010;138:1875-84 pubmed publisher
immunocytochemistry; human; 1:200; fig 1	Ploss A, Khetani S, Jones C, Syder A, Trehan K, Gaysinskaya V, et al. Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci U S A. 2010;107:3141-5 pubmed publisher
immunohistochemistry; human; 1:50; fig 2a immunohistochemistry; cat; 1:50; fig 2c	Karim M, Biswas S, Bhattacherjee P, Paterson C. Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes. Biotech Histochem. 2011;86:161-7 pubmed publisher
western blot; human; fig 1c	Chakraborty S, Mitra S, Falk M, Caplan S, Wheelock M, Johnson K, et al. E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells. J Biol Chem. 2010;285:10761-76 pubmed publisher
immunohistochemistry; human; 1:100; fig 2	Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, et al. Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro. Med Mol Morphol. 2009;42:204-11 pubmed publisher
immunocytochemistry; human; 1:25; fig 3 western blot; human; 1:1000; fig 3	Joannes A, Bonnomet A, Bindels S, Polette M, Gilles C, Burlet H, et al. Fhit regulates invasion of lung tumor cells. Oncogene. 2010;29:1203-13 pubmed publisher
western blot; domestic sheep; 1:5000; fig 3a	Sadowska G, Malaeb S, Stonestreet B. Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep. Am J Physiol Heart Circ Physiol. 2010;298:H179-88 pubmed publisher
immunocytochemistry; human; fig 5h western blot; human; fig 4a	Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, et al. Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells. Cell Tissue Res. 2009;338:283-93 pubmed publisher
immunohistochemistry - frozen section; human; 1:50; fig 1	Shimazaki J, Higa K, Kato N, Satake Y. Barrier function of cultivated limbal and oral mucosal epithelial cell sheets. Invest Ophthalmol Vis Sci. 2009;50:5672-80 pubmed publisher
western blot; human; fig 5	Matsumoto M, Oyamada K, Takahashi H, Sato T, Hatakeyama S, Nakayama K. Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways. Proteomics. 2009;9:3549-63 pubmed publisher
immunohistochemistry - frozen section; rat; 2 ug/ml western blot; rat; 2.5 ug/ml	Nicholson M, Lindsay L, Murphy C. Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy. Acta Histochem. 2010;112:42-52 pubmed publisher
immunohistochemistry - frozen section; rat; 1:5; fig 4 western blot; rat; 1:300; fig 7	Sobarzo C, Lustig L, Ponzio R, Suescun M, Denduchis B. Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats. Microsc Res Tech. 2009;72:868-77 pubmed publisher
western blot; rat; 1:1000	Waldow T, Witt W, Janke A, Ulmer A, Buzin A, Matschke K. Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide. J Surg Res. 2009;157:30-42 pubmed publisher
western blot; bovine; fig 3	Murakami T, Felinski E, Antonetti D. Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem. 2009;284:21036-46 pubmed publisher
western blot; rat; fig 3	McCaffrey G, Willis C, Staatz W, Nametz N, Quigley C, Hom S, et al. Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress. J Neurochem. 2009;110:58-71 pubmed publisher
immunohistochemistry - frozen section; human; 1:100; fig 1	Alanne M, Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J Histochem Cytochem. 2009;57:523-9 pubmed publisher
western blot; rat; 1:500	Tian J, Hao L, Chandra P, Jones D, Willams I, Gewirtz A, et al. Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2009;296:G348-55 pubmed publisher
immunocytochemistry; rat; 1:100; tbl 3	Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, et al. Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells. Histochem Cell Biol. 2009;131:411-24 pubmed publisher
immunocytochemistry; human; 1:50; loading ...; fig 4 western blot; human; loading ...; fig 2a	McLaughlin J, Lambert D, Padfield P, Burt J, O Neill C. The mycotoxin patulin, modulates tight junctions in caco-2 cells. Toxicol In Vitro. 2009;23:83-9 pubmed publisher
western blot; human; fig 2	Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, et al. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008;183:19-28 pubmed publisher
immunocytochemistry; dogs; 1:250; loading ...; fig 4b	Hemphill A, Vonlaufen N, Golaz J, Burgener I. Infection of primary canine duodenal epithelial cell cultures with Neospora caninum. J Parasitol. 2009;95:372-80 pubmed publisher
immunocytochemistry; human; fig 3b	Neuhaus W, Wirth M, Plattner V, Germann B, Gabor F, Noe C. Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media. Neurosci Lett. 2008;446:59-64 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 6 western blot; mouse; 1:1000; fig 6	Chen X, Lan X, Roche I, Liu R, Geiger J. Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. J Neurochem. 2008;107:1147-57 pubmed publisher
immunocytochemistry; human; 1:200	Van Hoof D, Braam S, Dormeyer W, Ward van Oostwaard D, Heck A, Krijgsveld J, et al. Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile. Stem Cells. 2008;26:2777-81 pubmed publisher
western blot; rat; fig 6	McCaffrey G, Seelbach M, Staatz W, Nametz N, Quigley C, Campos C, et al. Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia. J Neurochem. 2008;106:2395-409 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 2a	Bouschbacher M, Bomsel M, Verronèse E, Gofflo S, Ganor Y, Dezutter Dambuyant C, et al. Early events in HIV transmission through a human reconstructed vaginal mucosa. AIDS. 2008;22:1257-66 pubmed publisher
immunocytochemistry; rat; 1:100	Neuhaus W, Plattner V, Wirth M, Germann B, Lachmann B, Gabor F, et al. Validation of in vitro cell culture models of the blood-brain barrier: tightness characterization of two promising cell lines. J Pharm Sci. 2008;97:5158-75 pubmed publisher
immunohistochemistry - frozen section; domestic rabbit; fig 5 western blot; domestic rabbit; fig 4	Chen X, Gawryluk J, Wagener J, Ghribi O, Geiger J. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J Neuroinflammation. 2008;5:12 pubmed publisher
immunohistochemistry - frozen section; mouse; loading ...; fig 1d	Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, et al. Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro. J Mol Histol. 2008;39:265-73 pubmed publisher
immunocytochemistry; dogs; fig 5 western blot; dogs; fig 3	Paschoud S, Citi S. Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression. Mol Membr Biol. 2008;25:1-13 pubmed
immunocytochemistry; rat; fig 2c	Lussier C, Babeu J, Auclair B, Perreault N, Boudreau F. Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a coculture system. Am J Physiol Gastrointest Liver Physiol. 2008;294:G418-28 pubmed
immunocytochemistry; rat; 1:100; fig 7A	Kojima T, Takano K, Yamamoto T, Murata M, Son S, Imamura M, et al. Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes. Liver Int. 2008;28:534-45 pubmed
immunocytochemistry; rat; 1:100; fig 1 western blot; rat; 1:1000; fig 1	McCaffrey G, Staatz W, Quigley C, Nametz N, Seelbach M, Campos C, et al. Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo. J Neurochem. 2007;103:2540-55 pubmed publisher
immunohistochemistry - frozen section; human; loading ...; fig 7c immunocytochemistry; human; loading ...; fig 1d-f western blot; human; loading ...; fig 2b	Ohnemus U, Kohrmeyer K, Houdek P, Rohde H, Wladykowski E, Vidal S, et al. Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains. J Invest Dermatol. 2008;128:906-16 pubmed
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immunocytochemistry; human; fig 5	Mandell K, Berglin L, Severson E, Edelhauser H, Parkos C. Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function. Invest Ophthalmol Vis Sci. 2007;48:3928-36 pubmed
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immunocytochemistry; dogs; 1:250; tbl 1	Golaz J, Vonlaufen N, Hemphill A, Burgener I. Establishment and characterization of a primary canine duodenal epithelial cell culture. In Vitro Cell Dev Biol Anim. 2007;43:176-85 pubmed
immunohistochemistry - frozen section; rat; 1:100; fig 6	Morgan L, Shah B, Rivers L, Barden L, Groom A, Chung R, et al. Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis. Neuroscience. 2007;147:664-73 pubmed
immunocytochemistry; human; 1:200; fig 1 western blot; human; 1:500; fig 3	Beau I, Cotte Laffitte J, Amsellem R, Servin A. A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells. J Virol. 2007;81:8579-86 pubmed
immunocytochemistry; dogs; 1:100	Hernandez S, Chavez Munguia B, Gonzalez Mariscal L. ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture. Exp Cell Res. 2007;313:1533-47 pubmed
immunocytochemistry; human; 1:200; fig 6D	Stucke V, Timmerman E, Vandekerckhove J, Gevaert K, Hall A. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Mol Biol Cell. 2007;18:1744-55 pubmed
western blot; human; fig 2	Mitra S, Annamalai L, Chakraborty S, Johnson K, Song X, Batra S, et al. Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. Mol Biol Cell. 2006;17:5400-16 pubmed
immunohistochemistry; human; 1:50; fig 2	Anstrom J, Thore C, Moody D, Brown W. Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex. Histochem Cell Biol. 2007;127:205-13 pubmed
immunohistochemistry - paraffin section; domestic rabbit; 10,000 ug/ml; loading ...; fig 3d	Uchino Y, Shimmura S, Miyashita H, Taguchi T, Kobayashi H, Shimazaki J, et al. Amniotic membrane immobilized poly(vinyl alcohol) hybrid polymer as an artificial cornea scaffold that supports a stratified and differentiated corneal epithelium. J Biomed Mater Res B Appl Biomater. 2007;81:201-6 pubmed
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western blot; human; loading ...; fig 4	Herouy Y, Kahle B, Idzko M, Eberth I, Norgauer J, Pannier F, et al. Tight junctions and compression therapy in chronic venous insufficiency. Int J Mol Med. 2006;18:215-9 pubmed
immunohistochemistry; domestic rabbit; 2 ug/ml; fig 8	Gonzalez Mariscal L, Namorado M, Martin D, Sierra G, Reyes J. The tight junction proteins claudin-7 and -8 display a different subcellular localization at Henle's loops and collecting ducts of rabbit kidney. Nephrol Dial Transplant. 2006;21:2391-8 pubmed
western blot; human; 1:1000; loading ...; fig 2	Watson C, Hoare C, Garrod D, Carlson G, Warhurst G. Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. J Cell Sci. 2005;118:5221-30 pubmed
western blot; human; fig 2	Zhu L, Li X, Zeng R, Gorodeski G. Changes in tight junctional resistance of the cervical epithelium are associated with modulation of content and phosphorylation of occludin 65-kilodalton and 50-kilodalton forms. Endocrinology. 2006;147:977-89 pubmed
immunocytochemistry; pigs ; 1:100	Schierack P, Nordhoff M, Pollmann M, Weyrauch K, Amasheh S, Lodemann U, et al. Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine. Histochem Cell Biol. 2006;125:293-305 pubmed
immunocytochemistry; human; loading ...; fig 4d	Miyashita H, Shimmura S, Kobayashi H, Taguchi T, Asano Kato N, Uchino Y, et al. Collagen-immobilized poly(vinyl alcohol) as an artificial cornea scaffold that supports a stratified corneal epithelium. J Biomed Mater Res B Appl Biomater. 2006;76:56-63 pubmed
immunocytochemistry; human; 1:200; fig 4c	Haton C, Lebrun F, Benderitter M, Griffiths N. Maintenance of differentiation capacity of HT-29 cells after radiation exposure. Int J Radiat Biol. 2005;81:211-20 pubmed
immunocytochemistry; human; 1:250; loading ...; fig 4b western blot; human; 1:1000; loading ...; fig 4a	Clark E, Hoare C, Tanianis Hughes J, Carlson G, Warhurst G. Interferon gamma induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process. Gastroenterology. 2005;128:1258-67 pubmed
immunocytochemistry; rat; 1:100; fig 1 western blot; African green monkey; fig 4 western blot; dogs; fig 1 western blot; human; fig 4 western blot; hamsters; fig 4	Bordin M, D Atri F, Guillemot L, Citi S. Histone deacetylase inhibitors up-regulate the expression of tight junction proteins. Mol Cancer Res. 2004;2:692-701 pubmed
immunohistochemistry - frozen section; human; 1:100; fig 3	Go M, Kojima T, Takano K, Murata M, Ichimiya S, Tsubota H, et al. Expression and function of tight junctions in the crypt epithelium of human palatine tonsils. J Histochem Cytochem. 2004;52:1627-38 pubmed
immunohistochemistry; dogs; loading ...; fig 1	Somosy Z, Forgacs Z, Bognár G, Horvath K, Horváth G. Alteration of tight and adherens junctions on 50-Hz magnetic field exposure in Madin Darby canine kidney (MDCK) cells. ScientificWorldJournal. 2004;4 Suppl 2:75-82 pubmed
immunoprecipitation; human; fig 9 immunocytochemistry; human; fig 4 western blot; human; fig 7	Zeng R, Li X, Gorodeski G. Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation. J Clin Endocrinol Metab. 2004;89:5145-55 pubmed
immunocytochemistry; dogs; fig 8	Sundberg U, Beauchemin N, Obrink B. The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. J Cell Sci. 2004;117:1091-104 pubmed
western blot; human; fig 1b	Kahle B, Idzko M, Norgauer J, Rabe E, Herouy Y. Tightening tight junctions with compression therapy. J Invest Dermatol. 2003;121:1228-9 pubmed
immunohistochemistry - paraffin section; human; 1:100; fig 2c	Billings S, Walsh S, Fisher C, Nusrat A, Weiss S, Folpe A. Aberrant expression of tight junction-related proteins ZO-1, claudin-1 and occludin in synovial sarcoma: an immunohistochemical study with ultrastructural correlation. Mod Pathol. 2004;17:141-9 pubmed
immunohistochemistry; human; fig 1	Malminen M, Koivukangas V, Peltonen J, Karvonen S, Oikarinen A, Peltonen S. Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis. Br J Dermatol. 2003;149:255-60 pubmed
immunohistochemistry - frozen section; mouse; 1:1600	Evans S, Blyth D, Wong T, Sanjar S, West M. Decreased distribution of lung epithelial junction proteins after intratracheal antigen or lipopolysaccharide challenge: correlation with neutrophil influx and levels of BALF sE-cadherin. Am J Respir Cell Mol Biol. 2002;27:446-54 pubmed
immunocytochemistry; human	Tavelin S, Gråsjö J, Taipalensuu J, Ocklind G, Artursson P. Applications of epithelial cell culture in studies of drug transport. Methods Mol Biol. 2002;188:233-72 pubmed
immunohistochemistry; human; 1:100; fig 1	Busch C, Hanssen T, Wagener C, Obrink B. Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Hum Pathol. 2002;33:290-8 pubmed
immunohistochemistry - frozen section; human; loading ...	Gudjonsson T, Villadsen R, Nielsen H, Rønnov Jessen L, Bissell M, Petersen O. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev. 2002;16:693-706 pubmed
immunohistochemistry - frozen section; human	Gudjonsson T, Rønnov Jessen L, Villadsen R, Rank F, Bissell M, Petersen O. Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci. 2002;115:39-50 pubmed
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product information

Product Type :

Antibody

Product Name :

Occludin Monoclonal Antibody (OC-3F10)

Catalog # :

33-1500

Quantity :

100 ug

Price :

US 465.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rat

Applications :

ELISA: 0.1-1.0 ug/mL, Immunocytochemistry: 2-3 ug/mL, Western Blot: 0.1-1.0 ug/mL

Species :

Canine, Human, Mouse, Rat

Clone :

OC-3F10

Isotype :

IgG1, kappa

Storage :

-20 C

Description :

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.

Immunogen :

GST fusion protein consisting of the C-terminal region (~150aa) of human occludin.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1-1.0 ug/mL, Immunocytochemistry: 2-3 ug/mL, Western Blot: 0.1-1.0 ug/mL

Aliases :

AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein

more info or order :

Invitrogen product webpage