Claudin 4 Monoclonal Antibody (3E2C1), Alexa Fluor 488 | Invitrogen 329488 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Claudin 4 Monoclonal Antibody (3E2C1), Alexa Fluor 488

catalog :

329488

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

3E2C1

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; dogs; fig 6 western blot; dogs; fig 3	Fredriksson K, Van Itallie C, Aponte A, Gucek M, Tietgens A, Anderson J. Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. PLoS ONE. 2015;10:e0117074 pubmed publisher
immunohistochemistry; human; fig 4	Kirk A, Campbell S, Bass P, Mason J, Collins J. Differential expression of claudin tight junction proteins in the human cortical nephron. Nephrol Dial Transplant. 2010;25:2107-19 pubmed publisher
	Lashhab R, Rumley A, Arutyunov D, Rizvi M, You C, Dimke H, et al. The kidney anion exchanger 1 affects tight junction properties via claudin-4. Sci Rep. 2019;9:3099 pubmed publisher
	Hu Y, Blair J, Yuen R, Robinson W, von Dadelszen P. Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity. Mol Hum Reprod. 2015;21:452-65 pubmed publisher
	Schwed Lustgarten D, Thompson J, Yu G, Vachani A, Vaidya B, Rao C, et al. Use of circulating tumor cell technology (CELLSEARCH) for the diagnosis of malignant pleural effusions. Ann Am Thorac Soc. 2013;10:582-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Claudin 4 Monoclonal Antibody (3E2C1), Alexa Fluor 488

Catalog # :

329488

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 3 ug/mL

Species :

Canine, Human, Mouse, Rat

Clone :

3E2C1

Isotype :

IgG1

Storage :

Maintain refrigerated at 2-8 C for up to 1 month. For long term storage store at -20 C

Description :

Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl - permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Immunogen :

Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 3 ug/mL

Aliases :

Cep-r; claudin 4; CLAUDIN4; claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; Cpetr; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein

more info or order :

Invitrogen product webpage