| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; human; fig 5h
- immunohistochemistry - paraffin section; mouse; loading ...; fig s5f
| Werder R, Liu T, Abo K, Lindstrom Vautrin J, Villacorta Martin C, Huang J, et al. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022;8:eabo6566 pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 6b
| Tabariès S, Annis M, Lazaris A, Petrillo S, Huxham J, Abdellatif A, et al. Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern. Commun Biol. 2021;4:657 pubmed publisher |
- immunocytochemistry; dogs; loading ...; fig s2
- western blot; dogs; loading ...; fig 3j
| Kumar B, Ahmad R, Giannico G, Zent R, Talmon G, Harris R, et al. Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation. J Exp Clin Cancer Res. 2021;40:77 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig s7c
| Wijshake T, Zou Z, Chen B, Zhong L, Xiao G, Xie Y, et al. Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
- immunohistochemistry; human; 1:200; loading ...; fig 3c
| Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed publisher |
- immunocytochemistry; dogs; fig 1
- western blot; dogs; fig 1
| Tokuda S, Hirai T, Furuse M. Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells. PLoS ONE. 2017;12:e0182521 pubmed publisher |
- immunohistochemistry - paraffin section; dogs; 1.2 ug/ml; fig 4e
- western blot; dogs; fig 2
| Yokoyama N, Ohta H, Kagawa Y, Leela Arporn R, Dermlim A, Nisa K, et al. Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps. J Vet Med Sci. 2017;79:456-463 pubmed publisher |
- immunocytochemistry; domestic rabbit; 1:50; loading ...; fig 6a
| Martínez Rendón J, Sánchez Guzmán E, Rueda A, González J, Gulias Cañizo R, Aquino Jarquin G, et al. TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium. J Cell Physiol. 2017;232:1794-1807 pubmed publisher |
- immunocytochemistry; human; 1:700; fig 1b
| Niehues H, Schalkwijk J, van Vlijmen Willems I, Rodijk Olthuis D, van Rossum M, Wladykowski E, et al. Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function. J Allergy Clin Immunol. 2017;139:1979-1981.e13 pubmed publisher |
- immunocytochemistry; dogs; 1:200; tbl 5
| Hammer S, Becker A, Rateitschak K, Mohr A, Lüder Ripoli F, Hennecke S, et al. Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines. Int J Mol Sci. 2016;17: pubmed |
- immunohistochemistry - paraffin section; dogs; 1:200; loading ...; fig 2c
- western blot; dogs; 1:500; loading ...; fig 1g
| Ahn C, Shin D, Lee D, Kang S, Seok J, Kang H, et al. Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep. 2016;14:3697-703 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 1
- western blot; human; fig 1
| Yuki T, Tobiishi M, Kusaka Kikushima A, Ota Y, Tokura Y. Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17. PLoS ONE. 2016;11:e0161759 pubmed publisher |
- immunocytochemistry; dogs; 1:200; fig 5
- western blot; dogs; 1:1000; fig 3a
| Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3e
| Ocón B, Aranda C, Gámez Belmonte R, Suárez M, Zarzuelo A, Martinez Augustin O, et al. The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice. Biochem Pharmacol. 2016;116:73-88 pubmed publisher |
- immunocytochemistry; rat; 1:50; fig 4
- western blot; rat; 1:500; fig 2
| Xu S, Xue X, You K, Fu J. Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown. Respir Res. 2016;17:50 pubmed publisher |
- western blot; human; fig 5
| Thakkar A, Wang B, Picon Ruiz M, Buchwald P, Ince T. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat. 2016;157:77-90 pubmed publisher |
- western blot; pigs ; 1:1000; fig 7
| Ling K, Wan M, El Nezami H, Wang M. Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation. Chem Res Toxicol. 2016;29:823-33 pubmed publisher |
- western blot; human; fig 2
| Böhringer M, Pohlers S, Schulze S, Albrecht Eckardt D, Piegsa J, Weber M, et al. Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1. Cell Microbiol. 2016;18:889-904 pubmed publisher |
- immunocytochemistry; human; 1:50
- western blot; human; fig 2a
| MartÃnez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher |
- western blot; human; 0.5 ug/ml
| Smith N, Hinley J, Varley C, Eardley I, Trejdosiewicz L, Southgate J. The human urothelial tight junction: claudin 3 and the ZO-1α+ switch. Bladder (San Franc). 2015;2:e9 pubmed |
- immunohistochemistry; rat
| Liu W, Zhong Z, Cao L, Li H, Zhang T, Lin W. Paclitaxel-induced lung injury and its amelioration by parecoxib sodium. Sci Rep. 2015;5:12977 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; tbl 2
| Takahashi S, Kohashi K, Yamamoto H, Hirahashi M, Kumagai R, Takizawa N, et al. Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. Hum Pathol. 2015;46:1257-66 pubmed publisher |
- western blot; human; 1:167
| Todd M, Petty H, King J, Piana Marshall B, Sheller R, Cuevas M. Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines. Oncol Lett. 2015;10:156-162 pubmed |
- immunohistochemistry; rat; 1:100; fig 2
- western blot; rat; 1:1000; fig 2
| Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed publisher |
- immunohistochemistry; human; fig 3
| Bhagirath D, Zhao X, West W, Qiu F, Band H, Band V. Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes. Oncotarget. 2015;6:9018-30 pubmed |
- immunocytochemistry; dogs
- western blot; dogs
| Tokuda S, Furuse M. Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS ONE. 2015;10:e0119869 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Watari A, Hashegawa M, Yagi K, Kondoh M. Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers. Eur J Pharm Biopharm. 2015;89:232-8 pubmed publisher |
- immunocytochemistry; mouse; 1:500; fig 3
| Qiao X, Roth I, Féraille E, Hasler U. Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Cell Cycle. 2014;13:3059-75 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S. Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes. Biochem Biophys Res Commun. 2014;455:205-11 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100
| Jiwa L, van Diest P, Hoefnagel L, Wesseling J, Wesseling P, Moelans C. Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases. BMC Cancer. 2014;14:864 pubmed publisher |
- immunohistochemistry - frozen section; Xenopus laevis; fig 3
| Wiechmann A, Ceresa B, Howard E. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS ONE. 2014;9:e113810 pubmed publisher |
| Lejeune M, Moreau F, Chadee K. Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4. PLoS ONE. 2014;9:e113270 pubmed publisher |
- immunohistochemistry; human; 1:50; fig 1
| Ma F, Ding X, Fan Y, Ying J, Zheng S, Lu N, et al. A CLDN1-negative phenotype predicts poor prognosis in triple-negative breast cancer. PLoS ONE. 2014;9:e112765 pubmed publisher |
| Casselbrant A, Elias E, Fändriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed publisher |
- western blot; domestic sheep; 1:500
| Tao S, Duanmu Y, Dong H, Tian J, Ni Y, Zhao R. A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats. BMC Vet Res. 2014;10:235 pubmed publisher |
- immunohistochemistry; human
- western blot; human; 1:500
| Afshar Moghaddam N, Heidarpour M, Dashti S. Diagnostic value of claudin-4 marker in pleural and peritoneal effusion cytology: Does it differentiate between metastatic adenocarcinoma and reactive mesothelial cells?. Adv Biomed Res. 2014;3:161 pubmed publisher |
- immunocytochemistry; human; fig 5
| Kim C, Galloway J, Lee K, Searson P. Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers. Bioconjug Chem. 2014;25:1893-901 pubmed publisher |
- immunocytochemistry; dogs
- western blot; dogs
| Tokuda S, Higashi T, Furuse M. ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS ONE. 2014;9:e104994 pubmed publisher |
- immunocytochemistry; human
| Gusti V, Bennett K, Lo D. CD137 signaling enhances tight junction resistance in intestinal epithelial cells. Physiol Rep. 2014;2: pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1d
| Virman J, Soini Y, Kujala P, Luukkaala T, Salminen T, Sunela K, et al. Claudins as prognostic factors for renal cell cancer. Anticancer Res. 2014;34:4181-7 pubmed |
- western blot; dogs; fig 1
| Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim S, Tamura Y, et al. Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease. Am J Vet Res. 2014;75:746-51 pubmed publisher |
- immunocytochemistry; human; 1:100; fig 4
- immunocytochemistry; dogs; 1:100; fig 4
| Glotfelty L, Zahs A, Hodges K, Shan K, Alto N, Hecht G. Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration. Cell Microbiol. 2014;16:1767-83 pubmed publisher |
- immunocytochemistry; African green monkey
- western blot; African green monkey
| García Hernández V, Flores Maldonado C, Rincon Heredia R, Verdejo Torres O, Bonilla Delgado J, Meneses Morales I, et al. EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells. J Cell Physiol. 2015;230:105-15 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:250
| Ordonez N, Sahin A. Diagnostic utility of immunohistochemistry in distinguishing between epithelioid pleural mesotheliomas and breast carcinomas: a comparative study. Hum Pathol. 2014;45:1529-40 pubmed publisher |
- immunocytochemistry; rat; 1:200
- western blot; rat; 1:400
| Grosse B, Degrouard J, Jaillard D, Cassio D. Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins. Tissue Barriers. 2013;1:e25210 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100; loading ...; fig 2
| Somorácz A, Korompay A, Törzsök P, Patonai A, Erdélyi Belle B, Lotz G, et al. Tricellulin expression and its prognostic significance in primary liver carcinomas. Pathol Oncol Res. 2014;20:755-64 pubmed publisher |
- immunohistochemistry; human
| Melchor L, Molyneux G, Mackay A, Magnay F, Atienza M, Kendrick H, et al. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol. 2014;233:124-37 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 6
| Pirinen E, Soini Y. A survey of zeb1, twist and claudin 1 and 4 expression during placental development and disease. APMIS. 2014;122:530-8 pubmed publisher |
- western blot; pigs ; 1:2000
| Richter J, Pieper R, Zakrzewski S, Gunzel D, Schulzke J, Van Kessel A. Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon. Br J Nutr. 2014;111:1040-9 pubmed publisher |
- immunocytochemistry; dogs
- western blot; dogs
| Rincon Heredia R, Flores Benitez D, Flores Maldonado C, Bonilla Delgado J, García Hernández V, Verdejo Torres O, et al. Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways. Exp Cell Res. 2014;320:108-18 pubmed publisher |
- immunocytochemistry; mouse; 1:100; fig 1
- western blot; mouse; 1:500; fig 1
| Sugimoto K, Ichikawa Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, et al. The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. PLoS ONE. 2013;8:e75106 pubmed publisher |
- immunocytochemistry; human; fig 2
| Hwang M, Lee J, Lee K, Lee K. Think modular: a simple apoferritin-based platform for the multifaceted detection of pancreatic cancer. ACS Nano. 2013;7:8167-74 pubmed publisher |
- western blot; human; 1:1000
| Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, et al. p38? mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes. Arch Dermatol Res. 2014;306:131-41 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 1
| Zhu J, Gao P, Wang Z, Song Y, Li A, Xu Y, et al. Clinicopathological significance of claudin-4 in gastric carcinoma. World J Surg Oncol. 2013;11:150 pubmed publisher |
- immunocytochemistry; human; 1:100; fig 2
- immunohistochemistry; human; 1:100; fig 1
| Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, et al. Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano. Cell Tissue Res. 2013;354:481-94 pubmed publisher |
- western blot; human; fig 11
| Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K. Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2012;110:166-77 pubmed |
- immunohistochemistry - paraffin section; human; 10 ug/ml
| Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen N, et al. Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut. 2014;63:711-9 pubmed publisher |
- western blot; mouse; 1:250
| Díaz Coránguez M, Segovia J, López Ornelas A, Puerta Guardo H, Ludert J, Chávez B, et al. Transmigration of neural stem cells across the blood brain barrier induced by glioma cells. PLoS ONE. 2013;8:e60655 pubmed publisher |
- western blot; human; fig 6
| Benediktsdóttir B, Gudjonsson T, Baldursson O, Másson M. N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitro. Eur J Pharm Biopharm. 2014;86:55-63 pubmed publisher |
- immunohistochemistry; human
| Farley A, Morris L, Vroegindeweij E, Depreter M, Vaidya H, Stenhouse F, et al. Dynamics of thymus organogenesis and colonization in early human development. Development. 2013;140:2015-26 pubmed publisher |
- immunocytochemistry; human; 1:200; fig S8
- immunohistochemistry; human; 1:2000; fig S4
| Krishnan M, Lapierre L, Knowles B, Goldenring J. Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol Biol Cell. 2013;24:818-31 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 1
| Lappi Blanco E, Lehtonen S, Sormunen R, Merikallio H, Soini Y, Kaarteenaho R. Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis. Hum Pathol. 2013;44:895-907 pubmed publisher |
- western blot; human; fig s10
| Whitcomb D, Larusch J, Krasinskas A, Klei L, Smith J, Brand R, et al. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012;44:1349-54 pubmed publisher |
- immunocytochemistry; human; fig 2
| Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, et al. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. Cell Tissue Res. 2013;351:73-84 pubmed publisher |
- western blot; human; fig 4
| D Amato N, OSTRANDER J, Bowie M, Sistrunk C, Borowsky A, Cardiff R, et al. Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. PLoS ONE. 2012;7:e45684 pubmed publisher |
- immunocytochemistry; pigs ; loading ...; fig 2a
- western blot; pigs ; 1:250; loading ...
| Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, et al. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases. Toxicol Sci. 2012;130:180-90 pubmed publisher |
- western blot; human; fig 2
| Moran G, O NEILL C, McLaughlin J. GLP-2 enhances barrier formation and attenuates TNF?-induced changes in a Caco-2 cell model of the intestinal barrier. Regul Pept. 2012;178:95-101 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 4
| Lee K, Lee N, Kim J, Kang M, Yoo H, Kim H, et al. Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer. Biochem Biophys Res Commun. 2012;423:454-60 pubmed publisher |
- immunoprecipitation; human
- western blot; human
- immunoprecipitation; mouse
- western blot; mouse
| Tabariès S, Dupuy F, Dong Z, Monast A, Annis M, Spicer J, et al. Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes. Mol Cell Biol. 2012;32:2979-91 pubmed publisher |
- immunocytochemistry; human; fig 4
- western blot; human; fig 2
| Raiko L, Siljamäki E, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol. 2012;21:586-91 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100
- western blot; human; 1:1000; fig 2
| Ghule V, Gray C, Galimberti A, Anumba D. Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins. J Transl Med. 2012;10:40 pubmed publisher |
- immunocytochemistry; dogs; fig 1
- western blot; dogs; fig 2, 4
| Dukes J, Whitley P, Chalmers A. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE. 2012;7:e28659 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:75; fig 1
| Pezzolato M, Maina E, Lonardi S, Bozzetta E, Grassi F, Scanziani E, et al. Development of tertiary lymphoid structures in the kidneys of pigs with chronic leptospiral nephritis. Vet Immunol Immunopathol. 2012;145:546-50 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 2
| Riski M, Santala M, Soini Y, Talvensaari Mattila A. Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma. Tumour Biol. 2012;33:537-42 pubmed publisher |
- western blot; human; fig 1
| Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, et al. Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. Cell Tissue Res. 2011;346:369-81 pubmed publisher |
- immunocytochemistry; dogs; loading ...; fig s1a
| Larre I, Castillo A, Flores Maldonado C, Contreras R, Galván I, Muñoz Estrada J, et al. Ouabain modulates ciliogenesis in epithelial cells. Proc Natl Acad Sci U S A. 2011;108:20591-6 pubmed publisher |
- immunocytochemistry; human; 1:200; fig 1
| Buckner L, Schust D, Ding J, Nagamatsu T, Beatty W, Chang T, et al. Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. J Reprod Immunol. 2011;92:8-20 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; tbl 2
| Lorenzi L, Lonardi S, Petrilli G, Tanda F, Bella M, Laurino L, et al. Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders. Hum Pathol. 2012;43:209-15 pubmed publisher |
- immunohistochemistry; human; fig 7
| Horbul J, Schmechel S, Miller B, Rice S, Southern P. Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture. PLoS ONE. 2011;6:e22638 pubmed publisher |
- immunocytochemistry; human; 1:25; fig s7
| Dukes J, Fish L, Richardson J, Blaikley E, Burns S, Caunt C, et al. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Mol Biol Cell. 2011;22:3192-205 pubmed publisher |
- immunocytochemistry; human; fig 4
| Yamaguchi H, Kojima T, Ito T, Kyuno D, Kimura Y, Imamura M, et al. Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells. Cell Mol Biol Lett. 2011;16:385-97 pubmed publisher |
- immunohistochemistry - paraffin section; human; 0.25 ug/ml; loading ...; fig 2a
- immunocytochemistry; human; 0.25 ug/ml; loading ...; fig 7b
- western blot; human; loading ...; fig 7a
| Boylan K, Misemer B, De Rycke M, Andersen J, Harrington K, Kalloger S, et al. Claudin 4 Is differentially expressed between ovarian cancer subtypes and plays a role in spheroid formation. Int J Mol Sci. 2011;12:1334-58 pubmed publisher |
- immunohistochemistry - paraffin section; pigs ; 1:50; loading ...; fig 4
| Rimpiläinen R, Vakkala M, Rimpiläinen E, Jensen H, Rimpiläinen J, Erkinaro T, et al. Minimized and conventional cardiopulmonary bypass damage intestinal mucosal integrity. Scand Cardiovasc J. 2011;45:236-46 pubmed publisher |
- immunohistochemistry; human; 1:100; loading ...; fig 1a
| Lonardi S, Manera C, Marucci R, Santoro A, Lorenzi L, Facchetti F. Usefulness of Claudin 4 in the cytological diagnosis of serosal effusions. Diagn Cytopathol. 2011;39:313-7 pubmed publisher |
- immunohistochemistry; human; fig 5
| Maria O, Zeitouni A, Gologan O, Tran S. Matrigel improves functional properties of primary human salivary gland cells. Tissue Eng Part A. 2011;17:1229-38 pubmed publisher |
- immunocytochemistry; pigs ; 1:100; fig 3
- western blot; pigs ; 1:500; fig 3
| Pinton P, Braicu C, Nougayrede J, Laffitte J, Taranu I, Oswald I. Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism. J Nutr. 2010;140:1956-62 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 1
| Sung C, Han S, Kim S. Low expression of claudin-4 is associated with poor prognosis in esophageal squamous cell carcinoma. Ann Surg Oncol. 2011;18:273-81 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 3
| Väre P, Soini Y. Twist is inversely associated with claudins in germ cell tumors of the testis. APMIS. 2010;118:640-7 pubmed publisher |
- immunohistochemistry; human; 1:25
| Perrone F, Jocollè G, Pennati M, Deraco M, Baratti D, Brich S, et al. Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma. Eur J Cancer. 2010;46:2837-48 pubmed publisher |
- immunocytochemistry; human; fig 5
- immunohistochemistry; human; fig 2
- western blot; human; fig 2
| Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, et al. Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy. Am J Pathol. 2010;177:1344-55 pubmed publisher |
- western blot; human; fig 4
| Vockel M, Breitenbach U, Kreienkamp H, Brandner J. Somatostatin regulates tight junction function and composition in human keratinocytes. Exp Dermatol. 2010;19:888-94 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 3a
- western blot; human; 1:1000; loading ...; fig 2c
| Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, et al. Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells. Am J Pathol. 2010;177:698-712 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, et al. c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J Cell Physiol. 2010;225:720-33 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1d
| Kaarteenaho R, Merikallio H, Lehtonen S, Harju T, Soini Y. Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung. Respir Res. 2010;11:59 pubmed publisher |
- immunohistochemistry; human; 1:100; tbl 2
| Hsueh C, Chang Y, Tseng N, Liao C, Hsueh S, Chang J, et al. Expression pattern and prognostic significance of claudins 1, 4, and 7 in nasopharyngeal carcinoma. Hum Pathol. 2010;41:944-50 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 3a
- western blot; human; loading ...; fig 3b
| Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, et al. Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis. 2010;16:1311-21 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 3
| Kojima F, Ishida M, Takikita Suzuki M, Hotta M, Katsura K, Nagata A, et al. Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma. Oncol Rep. 2010;23:927-31 pubmed |
- immunohistochemistry; human; 1:100; loading ...
| Poliani P, Kisand K, Marrella V, Ravanini M, Notarangelo L, Villa A, et al. Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells. Am J Pathol. 2010;176:1104-12 pubmed publisher |
- immunohistochemistry; human; 1:100; fig 4
| Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, et al. Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro. Med Mol Morphol. 2009;42:204-11 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100
| Zorko M, Veranic P, Leskovec N, Pavlovic M, Lunder T. Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers. Clin Exp Dermatol. 2009;34:e949-52 pubmed publisher |
- immunohistochemistry - frozen section; rat; 5 ug/ml
- western blot; rat; 2 ug/ml
| Nicholson M, Lindsay L, Murphy C. Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy. Acta Histochem. 2010;112:42-52 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:400
| Tanaka M, Fukushima N, Noda N, Shibahara J, Kokudo N, Fukayama M. Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases. Hum Pathol. 2009;40:1543-52 pubmed publisher |
- immunocytochemistry; human; fig 3
| Natoli M, Felsani A, Ferruzza S, Sambuy Y, Canali R, Scarino M. Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells. Toxicol In Vitro. 2009;23:1510-5 pubmed publisher |
- immunohistochemistry - paraffin section; pigs ; 1:100
- immunocytochemistry; pigs ; fig 3
- western blot; pigs ; fig 3
- immunocytochemistry; human; 1:100; fig 3
- western blot; human; 1:500; fig 3
| Pinton P, Nougayrede J, del Rio J, Moreno C, Marin D, Ferrier L, et al. The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. Toxicol Appl Pharmacol. 2009;237:41-8 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100; fig 1
| Alanne M, Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J Histochem Cytochem. 2009;57:523-9 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000; fig 1c
- western blot; human; 1:1000; fig 1a
| Lanigan F, McKiernan E, Brennan D, Hegarty S, Millikan R, McBryan J, et al. Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int J Cancer. 2009;124:2088-97 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; tbl 1
| Ishida M, Kushima R, Okabe H. Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors). Oncol Rep. 2009;21:113-7 pubmed |
- immunohistochemistry - paraffin section; human; 1:100; fig 3
| Cao D, Polyak K, Halushka M, Nassar H, Kouprina N, Iacobuzio Donahue C, et al. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10:R91 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; tbl 3
| Vermi W, Lonardi S, Bosisio D, Uguccioni M, Danelon G, Pileri S, et al. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. J Pathol. 2008;216:356-64 pubmed publisher |
- immunocytochemistry; human; fig 4
- western blot; human; fig 1
| Aono S, Hirai Y. Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res. 2008;314:3326-39 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 1
| Weber C, Nalle S, Tretiakova M, Rubin D, Turner J. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 2008;88:1110-20 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 2a
| Bouschbacher M, Bomsel M, Verronèse E, Gofflo S, Ganor Y, Dezutter Dambuyant C, et al. Early events in HIV transmission through a human reconstructed vaginal mucosa. AIDS. 2008;22:1257-66 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1e
| Bello I, Vilen S, Niinimaa A, Kantola S, Soini Y, Salo T. Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue. Hum Pathol. 2008;39:1212-20 pubmed publisher |
- western blot; southern flounder; 1:500; fig 1c
| Tipsmark C, Luckenbach J, Madsen S, Kiilerich P, Borski R. Osmoregulation and expression of ion transport proteins and putative claudins in the gill of southern flounder (Paralichthys lethostigma). Comp Biochem Physiol A Mol Integr Physiol. 2008;150:265-73 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 1f
| Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F. Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. Int J Surg Pathol. 2008;16:218-21 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig 1c
| Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, et al. Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro. J Mol Histol. 2008;39:265-73 pubmed publisher |
- western blot; Tilapia; 1:500; fig 1
| Tipsmark C, Baltzegar D, Ozden O, Grubb B, Borski R. Salinity regulates claudin mRNA and protein expression in the teleost gill. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1004-14 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; fig 3b
| Ishikawa Y, Akishima Fukasawa Y, Ito K, Akasaka Y, Yokoo T, Ishii T. Histopathologic determinants of regional lymph node metastasis in early colorectal cancer. Cancer. 2008;112:924-33 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 2d
| Väre P, Loikkanen I, Hirvikoski P, Vaarala M, Soini Y. Low claudin expression is associated with high Gleason grade in prostate adenocarcinoma. Oncol Rep. 2008;19:25-31 pubmed |
- immunohistochemistry - paraffin section; human; 10 ug/ml; tbl 1
| Reynolds G, Harris H, Jennings A, Hu K, Grove J, Lalor P, et al. Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology. 2008;47:418-27 pubmed |
- immunohistochemistry - paraffin section; human; loading ...; fig 1b
| Tzelepi V, Tsamandas A, Vlotinou H, Vagianos C, Scopa C. Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms. Mod Pathol. 2008;21:22-30 pubmed |
- western blot; human; 1:2000; fig 8
| Atsumi T, Kato K, Uno K, Iijima K, Koike T, Imatani A, et al. Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer. Pathol Int. 2007;57:635-44 pubmed |
- immunohistochemistry; human; 1:50; fig 2
| Choi Y, Kim J, Kwon M, Choi J, Kim T, Bae D, et al. Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. Histol Histopathol. 2007;22:1185-95 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 1d
| Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, et al. Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med. 2007;20:139-43 pubmed |
- immunohistochemistry; human; fig 1
| Paschoud S, Bongiovanni M, Pache J, Citi S. Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol. 2007;20:947-54 pubmed |
- immunohistochemistry - paraffin section; human; 1 ug/ml; fig 1
- immunocytochemistry; human; 2 ug/ml; fig 7
- western blot; human; 0.5 ug/ml; fig 6B
| Southgate J, Varley C, Garthwaite M, Hinley J, Marsh F, Stahlschmidt J, et al. Differentiation potential of urothelium from patients with benign bladder dysfunction. BJU Int. 2007;99:1506-16 pubmed |
- immunohistochemistry - frozen section; human; fig 1
| Peltonen S, Riehokainen J, Pummi K, Peltonen J. Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis. Br J Dermatol. 2007;156:466-72 pubmed |
- immunohistochemistry - paraffin section; human; loading ...; fig 1c
| Soini Y, Talvensaari Mattila A. Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types. Int J Gynecol Pathol. 2006;25:330-5 pubmed |
- immunohistochemistry; human; loading ...; fig 2b
| Ichimiya S, Kojima T. Cellular networks of human thymic medullary stromas coordinated by p53-related transcription factors. J Histochem Cytochem. 2006;54:1277-89 pubmed |
- immunohistochemistry - paraffin section; human; fig 1a
- immunocytochemistry; human; fig 4b
- western blot; human; fig 3a
| Varley C, Garthwaite M, Cross W, Hinley J, Trejdosiewicz L, Southgate J. PPARgamma-regulated tight junction development during human urothelial cytodifferentiation. J Cell Physiol. 2006;208:407-17 pubmed |
- immunohistochemistry - frozen section; human; 1:167
- western blot; human
| Liévano S, Alarcón L, Chavez Munguia B, Gonzalez Mariscal L. Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia. Cell Tissue Res. 2006;324:433-48 pubmed |
- immunohistochemistry - paraffin section; human; 1:50
| Soini Y, Kinnula V, Kahlos K, Paakko P. Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura. J Clin Pathol. 2006;59:250-4 pubmed |
- immunohistochemistry - paraffin section; human; fig 2
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- western blot; human; 1:250; fig 1A
| de Oliveira S, de Oliveira I, de Souza W, Morgado Diaz J. Claudins upregulation in human colorectal cancer. FEBS Lett. 2005;579:6179-85 pubmed |
- western blot; human; 1:1000; fig 3
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- immunohistochemistry - paraffin section; human; loading ...; fig 2c
| Soini Y, Tommola S, Helin H, Martikainen P. Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype. Virchows Arch. 2006;448:52-8 pubmed |
- immunocytochemistry; pigs ; 1:100
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- immunohistochemistry - paraffin section; human; 1:500; fig 1
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- immunocytochemistry; human
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- immunohistochemistry - paraffin section; human; loading ...; fig 1e
| Soini Y. Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma. Hum Pathol. 2004;35:1531-6 pubmed |
- immunohistochemistry - frozen section; human; 1:100; fig 2
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- immunohistochemistry - paraffin section; human; 1:100; fig 2
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- immunohistochemistry - paraffin section; human; 1:500; fig 1
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- immunocytochemistry; human; fig 4
- western blot; human; fig 5
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- immunohistochemistry - frozen section; human
| Morita K, Tsukita S, Miyachi Y. Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease. Br J Dermatol. 2004;151:328-34 pubmed |
- immunohistochemistry - paraffin section; human; loading ...; fig 2
| Nichols L, Ashfaq R, Iacobuzio Donahue C. Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target. Am J Clin Pathol. 2004;121:226-30 pubmed |
- immunohistochemistry - paraffin section; human; 1:400; fig 5F
| Sato N, Fukushima N, Maitra A, Iacobuzio Donahue C, Van Heek N, Cameron J, et al. Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am J Pathol. 2004;164:903-14 pubmed |
- immunohistochemistry - paraffin section; human; fig 5
| Carson D, Lagow E, Thathiah A, Al Shami R, Farach Carson M, Vernon M, et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod. 2002;8:871-9 pubmed |
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| Singh A, Sharma S, Pagarware K, Siraji R, Ansari I, Mandal A, et al. Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation. Sci Rep. 2018;8:3719 pubmed publisher |
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