This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Synuclein alpha/beta Monoclonal Antibody (Syn 202)
catalog :
32-8200
quantity :
100 ug
price :
US 520.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Syn 202

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 4
Reference
Ouyang X, Wani W, Benavides G, Redmann M, Vo H, van Groen T, et al. Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo. Acta Pharm Sin B. 2023;13:4172-4184 pubmed publisher
Hernandez S, Tikhonova E, Baca K, Zhao F, Zhu X, Karamyshev A. Unexpected Implication of SRP and AGO2 in Parkinson's Disease: Involvement in Alpha-Synuclein Biogenesis. Cells. 2021;10: pubmed publisher
Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, et al. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018;38:1000-1014 pubmed publisher
Cabin D, Shimazu K, Murphy D, Cole N, Gottschalk W, McIlwain K, et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci. 2002;22:8797-807 pubmed
product information
Product Type :
Antibody
Product Name :
Synuclein alpha/beta Monoclonal Antibody (Syn 202)
Catalog # :
32-8200
Quantity :
100 ug
Price :
US 520.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
ELISA: Assay-dependent, Immunocytochemistry: 1-2 ug/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 ug/mL
Species :
Human, Mouse, Rat
Clone :
Syn 202
Isotype :
IgG2a
Storage :
-20 C
Description :
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
Immunogen :
Recombinant human alpha- and beta-synuclein.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunocytochemistry: 1-2 ug/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 ug/mL
Aliases :
AI838531; alphaSYN; alpha-synuclein; betaSYN; Beta-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Phosphoneuroprotein 14; PNP 14; SNCA; Sncb; Syn; synuclein alpha; synuclein alpha-140; synuclein beta; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); synuclein, beta
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA