Desmocollin 2/3 Monoclonal Antibody (7G6) | Invitrogen 32-6200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Desmocollin 2/3 Monoclonal Antibody (7G6)

catalog :

32-6200

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7G6

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; loading ...; fig 7a western blot; human; 1:1000; fig 9b	Li K, Wu R, Zhou M, Tong H, Luo K. Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system. Sci Adv. 2021;7:eabg7265 pubmed publisher
western blot; human; 1:500; loading ...; fig 4a	Shelton W, Thomas S, Alexander H, Thomes C, Conway D, Dubash A. Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion. Sci Rep. 2021;11:13295 pubmed publisher
immunocytochemistry; human western blot; human	Fang W, Liao L, Zeng F, Zhang P, Wu J, Shen J, et al. Desmocollin‑2 affects the adhesive strength and cytoskeletal arrangement in esophageal squamous cell carcinoma cells. Mol Med Rep. 2014;10:2358-64 pubmed publisher
immunohistochemistry - paraffin section; human; fig 3	Gerull B, Kirchner F, Chong J, Tagoe J, Chandrasekharan K, Strohm O, et al. Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population. Circ Cardiovasc Genet. 2013;6:327-36 pubmed publisher
western blot; human; fig 1	Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, et al. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008;183:19-28 pubmed publisher
immunocytochemistry; human; fig 5	Akat K, Bleck C, Lee Y, Haselmann Weiss U, Kartenbeck J. Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52. Cell Tissue Res. 2008;331:401-12 pubmed
immunohistochemistry - frozen section; human	Kaplan S, Gard J, Protonotarios N, Tsatsopoulou A, Spiliopoulou C, Anastasakis A, et al. Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm. 2004;1:3-11 pubmed
immunohistochemistry - paraffin section; human; fig 3 immunohistochemistry; human; fig 3	Kaplan S, Gard J, Carvajal Huerta L, Ruiz Cabezas J, Thiene G, Saffitz J. Structural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol. 2004;13:26-32 pubmed
	Nagler S, Ghoreishi Y, Kollmann C, Kelm M, Gerull B, Waschke J, et al. Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro. Tissue Barriers. 2023;11:2138061 pubmed publisher
	Raya Sandino A, Luissint A, Kusters D, Narayanan V, Flemming S, García Hernández V, et al. Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Mol Biol Cell. 2021;32:753-768 pubmed publisher
	Hiermaier M, Kliewe F, Schinner C, St xfc dle C, Maly I, Wanuske M, et al. The Actin-Binding Protein α-Adducin Modulates Desmosomal Turnover and Plasticity. J Invest Dermatol. 2021;141:1219-1229.e11 pubmed publisher
	Flemming S, Luissint A, Kusters D, Raya Sandino A, Fan S, Zhou D, et al. Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Mol Biol Cell. 2020;31:407-418 pubmed publisher
	Ungewiß H, Rötzer V, Meir M, Fey C, Diefenbacher M, Schlegel N, et al. Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion. Cell Mol Life Sci. 2018;75:4251-4268 pubmed publisher
	Ackermann M, Petrosino J, Manring H, Wright P, Shettigar V, Kilic A, et al. TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism. J Mol Cell Cardiol. 2017;112:49-57 pubmed publisher
	Kamekura R, Nava P, Feng M, Quirós M, Nishio H, Weber D, et al. Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell. 2015;26:3165-77 pubmed publisher
	Raiko L, Siljamäki E, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol. 2012;21:586-91 pubmed publisher
	Maass K, Shibayama J, Chase S, Willecke K, Delmar M. C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ Res. 2007;101:1283-91 pubmed

product information

Product Type :

Antibody

Product Name :

Desmocollin 2/3 Monoclonal Antibody (7G6)

Catalog # :

32-6200

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 5-10 ug, Western Blot: 1-3 ug/mL

Species :

Human

Clone :

7G6

Isotype :

IgG1

Storage :

-20 C

Description :

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

Immunogen :

Human desmocollin-2 extracellular domain.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 5-10 ug, Western Blot: 1-3 ug/mL

Aliases :

ARVC10; ARVD10; ARVD11; cadherin family member 2; Cadherin family member 3; CDHF2; CDHF3; CDHF5; CDHF6; CMD1BB; desmocollin 2; desmocollin 3; desmocollin-2; Desmocollin-3; desmocollin-4; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DGII/III; DSC; DSC1; DSC2; DSC3; DSC4; HDGC; HT-CP; PVA

more info or order :

Invitrogen product webpage