Desmoglein 2 Monoclonal Antibody (6D8) | Invitrogen 32-6100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Desmoglein 2 Monoclonal Antibody (6D8)

catalog :

32-6100

quantity :

100 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6D8

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:500; loading ...; fig 1b	Shelton W, Thomas S, Alexander H, Thomes C, Conway D, Dubash A. Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion. Sci Rep. 2021;11:13295 pubmed publisher
western blot; human; loading ...; fig 7a	LAW M, Ferreira R, Davis B, Higgins P, Kim J, Castellano R, et al. CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment. Breast Cancer Res. 2016;18:80 pubmed publisher
immunohistochemistry - paraffin section; human; fig 5b flow cytometry; human; loading ...; fig 2c	Ebert L, Tan L, Johan M, Min K, Cockshell M, Parham K, et al. A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis. Angiogenesis. 2016;19:463-86 pubmed publisher
immunocytochemistry; human western blot; human	Peitsch W, Doerflinger Y, Fischer Colbrie R, Huck V, Bauer A, Utikal J, et al. Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. PLoS ONE. 2014;9:e89491 pubmed publisher
immunohistochemistry; human; 1:10	Wex T, Kuester D, Monkemuller K, Stahr A, Fry L, Kandulski A, et al. Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. Hum Pathol. 2012;43:1745-54 pubmed publisher
western blot; human; fig 3	Chavez M, Buhr C, Petrie W, Wandinger Ness A, Kusewitt D, Hudson L. Differential downregulation of e-cadherin and desmoglein by epidermal growth factor. Dermatol Res Pract. 2012;2012:309587 pubmed publisher
immunohistochemistry; human; 1:10; fig 1	Wex T, Monkemuller K, Stahr A, Kuester D, Fry L, Völkel S, et al. Gastro-oesophageal reflux disease is associated with up-regulation of desmosomal components in oesophageal mucosa. Histopathology. 2012;60:405-15 pubmed publisher
	Tilwani S, Gandhi K, Narayan S, Ainavarapu S, Dalal S. Disruption of desmosome function leads to increased centrosome clustering in 14-3-3γ-knockout cells with supernumerary centrosomes. FEBS Lett. 2021;595:2675-2690 pubmed publisher
	Hankir M, Seyfried F, Schellinger I, Schlegel N, Arora T. Leaky Gut as a Potential Culprit for the Paradoxical Dysglycemic Response to Gastric Bypass-Associated Ileal Microbiota. Metabolites. 2021;11: pubmed publisher
	Franke W, Domke L, D xf6 rflinger Y, Zimbelmann R. The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature. Cell Tissue Res. 2020;379:75-92 pubmed publisher
	Domke L, Franke W. The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system. Cell Tissue Res. 2019;375:451-482 pubmed publisher
	Tan L, Mintoff C, Johan M, Ebert B, Fedele C, Zhang Y, et al. Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome. Oncotarget. 2016;7:46492-46508 pubmed publisher
	Silberberg M, Charron A, Bacallao R, Wandinger Ness A. Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol. 2005;288:F1153-63 pubmed

product information

Product Type :

Antibody

Product Name :

Desmoglein 2 Monoclonal Antibody (6D8)

Catalog # :

32-6100

Quantity :

100 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: Assay-dependent, Immunoprecipitation: 5-10 ug, Western Blot: 1-3 ug/mL

Species :

Human

Clone :

6D8

Isotype :

IgG1

Storage :

-20 C

Description :

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Immunogen :

Human desmoglein-2.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunoprecipitation: 5-10 ug, Western Blot: 1-3 ug/mL

Aliases :

AA408168; ARVC10; ARVD10; Cadherin family member 5; CDHF5; CMD1BB; D18Ertd293e; desmoglein 2; desmoglein-2; DSG2; DSG-2; HDGC; MGC117034; MGC117036; MGC117037

more info or order :

Invitrogen product webpage