Desmoglein 1 Monoclonal Antibody (27B2) | Invitrogen 32-6000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Desmoglein 1 Monoclonal Antibody (27B2)

catalog :

32-6000

quantity :

100 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

27B2

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2c	Ebert L, Tan L, Johan M, Min K, Cockshell M, Parham K, et al. A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis. Angiogenesis. 2016;19:463-86 pubmed publisher
immunohistochemistry; human	Heikinheimo K, Kurppa K, Laiho A, Peltonen S, Berdal A, Bouattour A, et al. Early dental epithelial transcription factors distinguish ameloblastoma from keratocystic odontogenic tumor. J Dent Res. 2015;94:101-11 pubmed publisher
western blot; human; fig 1	Gordon K, Kochkodan J, Blatt H, Lin S, Kaplan N, Johnston A, et al. Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol. 2013;133:712-722 pubmed publisher
immunohistochemistry; human; 1:10	Wex T, Kuester D, Monkemuller K, Stahr A, Fry L, Kandulski A, et al. Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. Hum Pathol. 2012;43:1745-54 pubmed publisher
immunohistochemistry; human; 1:10; fig 1	Wex T, Monkemuller K, Stahr A, Kuester D, Fry L, Völkel S, et al. Gastro-oesophageal reflux disease is associated with up-regulation of desmosomal components in oesophageal mucosa. Histopathology. 2012;60:405-15 pubmed publisher
western blot; human; fig 3	Lin S, Gordon K, Kaplan N, Getsios S. Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell. 2010;21:3902-14 pubmed publisher
immunoprecipitation; human; fig 2	Kanno M, Aoyama Y, Isa Y, Yamamoto Y, Kitajima Y. P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells. J Dermatol. 2008;35:317-24 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; tbl 1	Yang L, Shirakata Y, Shudou M, Dai X, Tokumaru S, Hirakawa S, et al. New skin-equivalent model from de-epithelialized amnion membrane. Cell Tissue Res. 2006;326:69-77 pubmed
	Yang T, Sim K, Ko G, Ahn J, Kim H, Park S. FAM167A is a key molecule to induce BCR-ABL-independent TKI resistance in CML via noncanonical NF-κB signaling activation. J Exp Clin Cancer Res. 2022;41:82 pubmed publisher
	Chavatte L, Juan M, Mounicou S, Leblanc Noblesse E, Pays K, Nizard C, et al. Elemental and molecular imaging of human full thickness skin after exposure to heavy metals. Metallomics. 2020;12:1555-1562 pubmed publisher
	Chamcheu J, Esnault S, Adhami V, Noll A, Banang Mbeumi S, Roy T, et al. Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. Cells. 2019;8: pubmed publisher
	Yang Q, Pinto V, Duan W, Paxton E, Dessauer J, Ryan W, et al. In vitro Characteristics of Heterogeneous Equine Hoof Progenitor Cell Isolates. Front Bioeng Biotechnol. 2019;7:155 pubmed publisher
	Wagner T, Beer L, Gschwandtner M, Eckhart L, Kalinina P, Laggner M, et al. The differentiation-associated keratinocyte protein cornifelin contributes to cell-cell adhesion of epidermal and mucosal keratinocytes. J Invest Dermatol. 2019;: pubmed publisher
	Domke L, Franke W. The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system. Cell Tissue Res. 2019;375:451-482 pubmed publisher
	Nanni M, Ranieri D, Rosato B, Torrisi M, Belleudi F. Role of Fibroblast Growth Factor Receptor 2b in the Cross Talk between Autophagy and Differentiation: Involvement of Jun N-Terminal Protein Kinase Signaling. Mol Cell Biol. 2018;38: pubmed publisher
	Harmon R, Simpson C, Johnson J, Koetsier J, Dubash A, Najor N, et al. Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation. J Clin Invest. 2013;123:1556-70 pubmed publisher
	Raiko L, Siljamäki E, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol. 2012;21:586-91 pubmed publisher
	Tran Q, Kennedy L, Leon Carrion S, Bodreddigari S, Goodwin S, Sutter C, et al. EGFR regulation of epidermal barrier function. Physiol Genomics. 2012;44:455-69 pubmed publisher
	Biedermann T, Pontiggia L, Böttcher Haberzeth S, Tharakan S, Braziulis E, Schiestl C, et al. Human eccrine sweat gland cells can reconstitute a stratified epidermis. J Invest Dermatol. 2010;130:1996-2009 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Desmoglein 1 Monoclonal Antibody (27B2)

Catalog # :

32-6000

Quantity :

100 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Frozen): 20-50 ug/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 5-10 ug, Western Blot: 1-3 ug/mL

Species :

Human

Clone :

27B2

Isotype :

IgG1

Storage :

-20 C

Description :

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Immunogen :

Human desmoglein-1 intracellular domain.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 20-50 ug/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 5-10 ug, Western Blot: 1-3 ug/mL

Aliases :

Cadherin family member 4; CDHF4; desmoglein 1; desmoglein 1 beta; desmoglein 1 gamma; desmoglein-1; Desmosomal glycoprotein 1; DG1; DSG; DSG1; Dsg1b; Dsg1c; EPKHE; EPKHIA; Pemphigus foliaceus antigen; PPKS1; SPPK1

more info or order :

Invitrogen product webpage