PTBP1 Monoclonal Antibody (7) | Invitrogen 32-5000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PTBP1 Monoclonal Antibody (7)

catalog :

32-5000

quantity :

100 µg

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human	Yin Y, Zhang S, Luo H, Zhang X, Geng G, Li J, et al. Interleukin 7 up-regulates CD95 protein on CD4+ T cells by affecting mRNA alternative splicing: priming for a synergistic effect on HIV-1 reservoir maintenance. J Biol Chem. 2015;290:35-45 pubmed publisher
western blot; human; 1:1000	Juan W, Roca X, Ong S. Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing. PLoS ONE. 2014;9:e95210 pubmed publisher
	Khoury G, Lee M, Ramarathinam S, McMahon J, Purcell A, Sonza S, et al. The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency. Front Genet. 2021;12:680725 pubmed publisher
	Khoury G, Mota T, Li S, Tumpach C, Lee M, Jacobson J, et al. HIV latency reversing agents act through Tat post translational modifications. Retrovirology. 2018;15:36 pubmed publisher
	Jiang Y, Li Z, Liu Z, Chen D, Wu W, Du Y, et al. mirDNMR: a gene-centered database of background de novo mutation rates in human. Nucleic Acids Res. 2017;45:D796-D803 pubmed publisher
	Liu G, Xu J, Liu D, Ding Q, Liu M, Chen R, et al. Regulation of plasma lipid homeostasis by hepatic lipoprotein lipase in adult mice. J Lipid Res. 2016;57:1155-61 pubmed publisher
	Snyder M, Adelman A, Gao W. Gestational methylazoxymethanol exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning. Neuropsychopharmacology. 2013;38:328-40 pubmed publisher
	Pautz A, Linker K, Hubrich T, Korhonen R, Altenhöfer S, Kleinert H. The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. J Biol Chem. 2006;281:32294-302 pubmed

product information

Product Type :

Antibody

Product Name :

PTBP1 Monoclonal Antibody (7)

Catalog # :

32-5000

Quantity :

100 µg

Price :

US 480.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 2-4 µg/mL

Species :

Human

Clone :

Isotype :

IgG1

Storage :

-20°C

Description :

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Immunogen :

Recombinant human PTB protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 2-4 µg/mL

Aliases :

57 kDa RNA-binding protein PPTB-1; AA407203; AL033359; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNPI; HNRNP-I; HNRPI; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; polypyrimidine tract-binding protein; polypyrimidine tract-binding protein 1; polypyrimidine-tract binding protein; pPTB; PTB; PTB-1; PTB2; PTB3; PTB4; PTBP1; PTB-T; Pybp; Pybp1; Pybp2; pyrimidine binding protein 1; pyrimidine binding protein 2; RNA-binding protein

more info or order :

Invitrogen product webpage