| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig 1c
| Jin Z, Liang F, Yang J, Mei W. hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer. PLoS Genet. 2017;13:e1006672 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 4c
| Ghanem L, Kromer A, Silverman I, Ji X, Gazzara M, Nguyen N, et al. Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Mol Cell Biol. 2018;38: pubmed publisher |
- western blot; human; loading ...; fig 3a
| Ji X, Humenik J, Yang D, Liebhaber S. PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing. Nucleic Acids Res. 2018;46:2030-2044 pubmed publisher |
- RNA immunoprecipitation; human; loading ...; fig 1d
- western blot; human; loading ...; fig 1c
| Zhang L, Yang Z, Trottier J, Barbier O, Wang L. Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay. Hepatology. 2017;65:604-615 pubmed publisher |
- western blot; rat; fig 4
- western blot; mouse; fig 7
| Llorian M, Gooding C, Bellora N, Hallegger M, Buckroyd A, Wang X, et al. The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators. Nucleic Acids Res. 2016;44:8933-8950 pubmed |
- western blot; human; loading ...; fig 3e
| Tang S, Luo S, Ho J, Ly P, Goh E, Roca X. Characterization of the Regulation of CD46 RNA Alternative Splicing. J Biol Chem. 2016;291:14311-23 pubmed publisher |
- RNA immunoprecipitation; human; fig 1
| Marnef A, Jády B, Kiss T. Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol. Nucleic Acids Res. 2016;44:1342-53 pubmed publisher |
| Panas M, Kedersha N, McInerney G. Methods for the characterization of stress granules in virus infected cells. Methods. 2015;90:57-64 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Marzese D, Liu M, Huynh J, Hirose H, Donovan N, Huynh K, et al. Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome. Pigment Cell Melanoma Res. 2015;28:82-93 pubmed publisher |
- western blot; human; fig 6
| Ye J, Cardona M, Llovera M, Comella J, Sanchis D. Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway. J Mol Cell Cardiol. 2012;53:578-87 pubmed publisher |
- western blot; mouse; 1:2000; fig 2
| Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, et al. PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013;23:1824-35 pubmed publisher |
- western blot; mouse; fig 4
| Smith P, Delay C, Girard J, Papon M, Planel E, Sergeant N, et al. MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy. Hum Mol Genet. 2011;20:4016-24 pubmed publisher |
- immunocytochemistry; human; 1:50; fig 5
| Borghese F, Michiels T. The leader protein of cardioviruses inhibits stress granule assembly. J Virol. 2011;85:9614-22 pubmed publisher |
- immunohistochemistry; mouse; fig 2
| Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, et al. PTBP1 is required for embryonic development before gastrulation. PLoS ONE. 2011;6:e16992 pubmed publisher |
- western blot; mouse; fig 2
| Smith P, Al Hashimi A, Girard J, Delay C, Hébert S. In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem. 2011;116:240-7 pubmed publisher |
- immunocytochemistry; mouse; 1:50; fig 4
| Paul S, Michiels T. Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness. J Gen Virol. 2006;87:1237-46 pubmed |
- western blot; human; 1:250; fig 2
| Adair R, Liebisch G, Su Y, COLBERG POLEY A. Alteration of cellular RNA splicing and polyadenylation machineries during productive human cytomegalovirus infection. J Gen Virol. 2004;85:3541-53 pubmed |
| Zhang Y, Gregorich Z, Wang Y, Braz C, Zhang J, Liu Y, et al. Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy. JCI Insight. 2023;8: pubmed publisher |
| Yang H, Sun W, Bi T, Wang Q, Wang W, Xu Y, et al. The PTBP1‑NCOA4 axis promotes ferroptosis in liver cancer cells. Oncol Rep. 2023;49: pubmed publisher |
| Hwang H, Yun S, Arcanjo R, Divyanshi -, Chen S, Mei W, et al. Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER. Cell Rep. 2022;41:111802 pubmed publisher |
| Lizcano Perret B, Lardinois C, Wavreil F, Hauchamps P, Herinckx G, Sorgeloos F, et al. Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic. PLoS Pathog. 2022;18:e1011042 pubmed publisher |
| Ding Y, Gao S, Zheng J, Chen X. Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism. Cancer Metab. 2022;10:20 pubmed publisher |
| Guo W, Guo Q, Liu Y, Yan D, Jin L, Zhang R, et al. Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance. Cell Death Dis. 2022;13:904 pubmed publisher |
| Lan C, Zhang H, Wang K, Liu X, Zhao Y, Guo Z, et al. The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression. Cell Death Dis. 2022;13:835 pubmed publisher |
| Shen T, Chen C, Tsai T, Jhan M, Bai C, Yen Y, et al. Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation. JCI Insight. 2022;7: pubmed publisher |
| Shetty S, Kiledjian N, Copeland P. The selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation. PLoS ONE. 2022;17:e0271453 pubmed publisher |
| D Angeli V, Monz xf3 n Casanova E, Matheson L, Gizlenci x, Petkau G, Gooding C, et al. Polypyrimidine tract binding protein 1 regulates the activation of mouse CD8 T cells. Eur J Immunol. 2022;52:1058-1068 pubmed publisher |
| Segelle A, Núñez Álvarez Y, Oldfield A, Webb K, Voigt P, Luco R. Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing. Cell Rep. 2022;38:110357 pubmed publisher |
| Monz xf3 n Casanova E, Bates K, Smith C, Turner M. Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice. Eur J Immunol. 2021;51:2266-2273 pubmed publisher |
| Kosar M, Giannattasio M, Piccini D, Maya Mendoza A, García Benítez F, Bartkova J, et al. The human nucleoporin Tpr protects cells from RNA-mediated replication stress. Nat Commun. 2021;12:3937 pubmed publisher |
| Choksi A, Parulekar A, Pant R, Shah V, Nimma R, Firmal P, et al. Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1. Cancer Metab. 2021;9:16 pubmed publisher |
| Smith E, Benbahouche N, Morris K, Wilczynska A, Gillen S, Schmidt T, et al. The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction. Nucleic Acids Res. 2021;49:458-478 pubmed publisher |
| Ruan X, Li P, Ma Y, Jiang C, Chen Y, Shi Y, et al. Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis. J Clin Invest. 2021;131: pubmed publisher |
| Desideri F, Cipriano A, Petrezselyova S, Buonaiuto G, Santini T, Kaspárek P, et al. Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1. Cell Rep. 2020;33:108548 pubmed publisher |
| Toki N, Takahashi H, Sharma H, Valentine M, Rahman F, Zucchelli S, et al. SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies. Nucleic Acids Res. 2020;48:11626-11644 pubmed publisher |
| Toki N, Takahashi H, Zucchelli S, Gustincich S, Carninci P. Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation. FEBS Lett. 2020;594:4357-4369 pubmed publisher |
| Senoo M, Hozoji H, Ishikawa Yamauchi Y, Takijiri T, Ohta S, Ukai T, et al. RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3. J Reprod Dev. 2020;66:459-467 pubmed publisher |
| Zheng Q, Zhang X, Yang H, Xie J, Xie Y, Chen J, et al. Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner. Viruses. 2019;11: pubmed publisher |
| Andersen R, Hong S, Lim J, Cui M, Harpur B, Hwang E, et al. The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo. Dev Cell. 2019;49:632-642.e7 pubmed publisher |
| Zhang L, Yang Z, Huang W, Wu J. H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis. Cell Death Dis. 2019;10:168 pubmed publisher |
| Yap K, Mukhina S, Zhang G, Tan J, Ong H, Makeyev E. A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival. Mol Cell. 2018;72:525-540.e13 pubmed publisher |
| Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, et al. The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway. Stem Cell Reports. 2018;11:741-755 pubmed publisher |
| Hamid F, Makeyev E. A mechanism underlying position-specific regulation of alternative splicing. Nucleic Acids Res. 2017;45:12455-12468 pubmed publisher |
| Monzon Casanova E, Screen M, Díaz Muñoz M, Coulson R, Bell S, Lamers G, et al. The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat Immunol. 2018;19:267-278 pubmed publisher |
| Soemedi R, Cygan K, Rhine C, Wang J, Bulacan C, Yang J, et al. Pathogenic variants that alter protein code often disrupt splicing. Nat Genet. 2017;49:848-855 pubmed publisher |
| Ohsawa N, Koebis M, Mitsuhashi H, Nishino I, Ishiura S. ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1. Genes Cells. 2015;20:121-34 pubmed publisher |
| Pradeepa M, Sutherland H, Ule J, Grimes G, Bickmore W. Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet. 2012;8:e1002717 pubmed publisher |
| Sasabe T, Futai E, Ishiura S. Polypyrimidine tract-binding protein 1 regulates the alternative splicing of dopamine receptor D2. J Neurochem. 2011;116:76-81 pubmed publisher |
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| Delhaye S, van Pesch V, Michiels T. The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins. J Virol. 2004;78:4357-62 pubmed |
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